| PUBLICATIONS (Ranked by impact factor of the journal) | Human Serine Protease HTRA1 Positively Regulates Osteogenesis of Human Bone Marrow-Derived Mesenchymal Stem Cells and Mineralization of Differentiating Bone-Forming Cells through the Modulation of Extracellular Matrix Protein Researchers investigated the role of HTRA1 in mesenchymal stem cell osteogenesis and suggested a potential mechanism through which it controls matrix mineralization by differentiating bone-forming cells. [Stem Cells] Abstract Snail1 Controls TGF-β Responsiveness and Differentiation of Mesenchymal Stem Cells Researchers demonstrated a new role for Snail1 in transforming growth factor-β (TGF-β) response and mesenchymal stem cell maintenance. [Oncogene] Abstract Mesenchymal Stem Cells as a Novel Carrier for Targeted-Delivery of Gene in Cancer Therapy Based on Non-Viral Transfection Scientists showed the effectiveness of non-viral vectors in transferring the therapeutic gene to mesenchymal stem cells (MSCs) and the feasible of using MSCs as a targeted gene delivery carrier, indicating that MSCs could be a promising tumor target delivery vehicle in cancer gene therapy based on non-viral gene recombination. [Mol Pharm] Abstract Microvesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells Stimulated by Hypoxia Promote Angiogenesis Both In Vitro and In Vivo Results indicate that membrane microvesicle releasing is one of the major mechanisms underlying the effectiveness of mesenchymal stem cell therapy by promoting angiogenesis. [Stem Cells Dev] Abstract Conditioned Mesenchymal Stem Cells Attenuate Progression of Chronic Kidney Disease through Inhibition of Epithelial-to-Mesenchymal Transition and Immune Modulation Mesenchymal stem cells were cultured in media containing various concentrations of basic fibroblast growth factor, epidermal growth factor and ascorbic acid 2-phosphate to investigate whether hepatocyte growth factor secretion could be increased by the stimulation of these growth factors. [J Cell Mol Med] Abstract Activation of Toll-Like Receptor 3 (TLR3) Amplifies Mesenchymal Stem Cell Trophic Factors and Enhances Therapeutic Potency Using the RNA mimetic polyinosinic-polycytidylic acid [poly(I:C)] to engage mesenchymal stem cell (MSC) TLR3, researchers found that poly(I:C), signaling through multiple mitogen-activated protein kinase pathways, induced therapeutically relevant trophic factors such as interleukin-6-type cytokines, stromal-derived factor 1, hepatocyte growth factor, and vascular endothelial growth factor while slightly inhibiting the proliferation and migration potentials of MSCs. [Am J Physiol Cell Physiol] Abstract Differential Effects of Mixed Lymphocyte Reaction Supernatant on Human Mesenchymal Stromal Cells In addition to phenotype and proliferation, researchers monitored mesenchymal stromal cell differentiation, gene expression and the support of CD34+ hematopoietic stem and progenitor cells after priming with mixed lymphocyte reaction supernatant. [Exp Hematol] Abstract Surface-Bound Orientated Jagged-1 Enhances Osteogenic Differentiation of Human Periodontal Ligament-Derived Mesenchymal Stem Cells Researchers investigated the ability to control differentiation of human periodontal ligament derived mesenchymal stem cells using modified surfaces containing the affinity immobilized Notch ligand, Jagged-1. [J Biomed Mater Res A] Abstract |
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