Mesenchymal Cell News Volume 4.32 | Aug 13 2012

Effects of Intracoronary Delivery of Allogenic Bone Marrow-Derived Stem Cells Expressing Heme Oxygenase-1 on Myocardial Reperfusion Injury
Scientists investigated the effects of intracoronary infusion of allogenic bone marrow cells overexpressing heme oxygenase-1 in the porcine model of myocardial infarction. [Thromb Haemost] Abstract

Hypoxia-Inducible Factor 1a Contributes to Cardiac Healing in Mesenchymal Stem Cells Mediated Cardiac Repair
Researchers provided evidence for a crucial role of hypoxia-inducible factor 1a (HIF-1a) on mesenchymal stem cell biology and suggested the stabilization of HIF-1a as a novel strategy for cellular therapies. [Stem Cells Dev] Abstract

H3K9me-Enhanced DNA Hypermethylation of p16INK4a Gene: An Epigenetic Signature for Spontaneous Transformation of Rat Mesenchymal Stem Cells
To explore the mechanisms underlying spontaneous transformation of mesenchymal stem cells (MSC), changes in senescence-associated molecules, particularly the epigenetic modification of p16INK4a gene including histone H3 lysines 27/9 methylation (H3K27/9me) and DNA methylation, were investigated in cultured adult rat bone marrow MSCs at different stages during the transformation process. [Stem Cells Dev] Abstract

β-Cell Regeneration Mediated by Human Bone Marrow Mesenchymal Stem Cells
Investigators tested the ability of human bone marrow mesenchymal stem cells genetically modified to transiently express vascular endothelial growth factor or pancreatic-duodenal homeobox 1 to reverse diabetes and whether these cells were differentiated into β-cells or mediated recovery through alternative mechanisms. [PLoS One] Full Article

Adenoviral Transduction of Mesenchymal Stem Cells: In Vitro Responses and In Vivo Immune Responses after Cell Transplantation
Researchers investigated whether adenovirus (Ad)-modification of mesenchymal stem cells (MSCs) alters their immunological properties in vitro and in vivo. They found that Ad-transduction of MSCs does not lead to up-regulation of major histocompatibility complex class I and II and co-stimulatory molecules CD80 and CD86. [PLoS One] Full Article

The Effects of Cyclic Hydrostatic Pressure on Viability and Chondrogenesis of Human Adipose and Bone Marrow Derived Mesenchymal Stem Cells in Three-Dimensional Agarose Constructs
Scientists investigated the effects of cyclic hydrostatic pressure on chondrogenic differentiation of human adipose-derived stem cells seeded in three-dimensional agarose constructs in complete growth medium in the absence of chondrogenic inductive factors. [Tissue Eng Part A] Abstract

Human Adipose Derived Stem Cells Enhance the Angiogenic Potential of Endothelial Progenitor Cells But Not of Human Umbilical Vein Endothelial Cells
Data suggests that cellular communications between adipose derived stem cells and endothelial progenitor cells (EPCs) is triggered by cell-cell contact or at least close proximity, which is partially mediated by secreted VEGF leading to the enhancement of angiogenic properties in EPCs but not in human umbilical vein endothelial cells. [Tissue Eng Part A] Abstract

Human Adipose Tissue-Derived Multilineage Progenitor Cells Exposed to Oxidative Stress Induce Neurite Outgrowth in PC12 Cells through p38 MAPK Signaling
Researchers examined the role of oxidative stress on human adipose-derived multilineage progenitor cells in neurite outgrowth in cells of the rat pheochromocytoma cell line (PC12). [BMC Cell Biol] Abstract | Full Article

A Novel Strategy to Enhance Mesenchymal Stem Cell Migration Capacity and Promote Tissue Repair in an Injury Specific Fashion
Investigators demonstrated that promoting migration of mesenchymal stem cells could increase their therapeutic potential and indicates a new therapeutic paradigm for organ repair. [Cell Transplant] Abstract

NIH Announces Winners of Undergraduate Biomedical Engineering Competition
The National Institute of Biomedical Imaging and Bioengineering announced the winners in the three categories of the DEBUT challenge, a biomedical engineering design competition for teams of undergraduate students. [National Institutes of Health (NIH), United States] Press Release

Wellcome Trust and MRC Invest in World-Class Stem Cell Institute at Cambridge
Two of the UK’s largest funders of medical research are to invest £8 million in a new world-leading centre for stem cell biology and medicine at the University of Cambridge. The Wellcome Trust-Medical Research Council (MRC) Cambridge Stem Cell Institute will advance our understanding of stem cells and their potential to treat a range of life-threatening conditions that currently have no effective cures. [University of Cambridge]
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