Demethylation of Epiregulin Gene by Histone Demethylase FBXL11 and BCL6 Corepressor Inhibits Osteo/Dentinogenic Differentiation Scientists investigated FBXL11, a lysine-specific 2A histone demethylase, which is evolutionarily conserved, ubiquitously expressed, and a member of the JmjC-domain-containing histone demethylase family. They found that FBXL11 regulated osteo/dentinogenic differentiation in mesenchymal stem cells. [Stem Cells] Abstract Cardiac Progenitors Derived from Reprogrammed Mesenchymal Stem Cells Contribute to Angiomyogenic Repair of the Infarcted Heart Researchers reported efficient reprogramming of multipotent bone marrow mesenchymal stem cells (MSCs) to pluripotent status. The resultant MSC derived induced pluripotent stem cells and their derived progenitors effectively repaired the infarcted heart. [Basic Res Cardiol] Abstract | Full Article TNF-α Suppresses the Mesenchymal Stem Cell Osteogenesis Promoter miR-21 in Estrogen Deficiency-Induced Osteoporosis Investigators identified a novel mechanism that TNF-α suppressing the functional axis of a key microRNA(miR)-21 contributes to estrogen deficiency-induced osteoporosis. miR-21 was significantly down-regulated in mesenchymal stem cells derived from estrogen deficiency-induced osteoporosis. [J Bone Miner Res] Abstract Control of 3D Substrate Stiffness to Manipulate Mesenchymal Stem Cell Fate toward Neuronal or Glial Lineages Researchers investigated the change of matrix stiffness on the influence of neurogenic differentiation of human mesenchymal stem cells. [Acta Biomater] Abstract Juxtacrine and Paracrine Interactions of Rat Marrow Derived Mesenchymal Stem Cells, Muscle Derived Satellite Cells and Neonatal Cardiomyocytes with Endothelial Cells in Angiogenesis Dynamics Scientists investigated the juxtacrine and paracrine interaction between three different cells, namely rat marrow-derived mesenchymal stem cells, rat muscle-derived satellite cells and rat neonatal cardiomyocytes, and endothelial cells during the angiogenesis process. [Stem Cell Dev] Abstract MSM Enhances GH Signaling via the Jak2/STAT5b Pathway in Osteoblast-Like Cells and Osteoblast Differentiation through the Activation of STAT5b in MSCs Researchers investigated the effects of methylsulfonylmethane (MSM) on the growth hormone (GH) signaling via the Janus kinase (Jak)/signal transducers and activators of transcription (STAT) pathway in osteoblasts and the differentiation of primary bone marrow mesenchymal stem cells (MSCs). [PLoS One] Full Article Combination Treatment of Hypothermia and Mesenchymal Stromal Cells Amplifies Neuroprotection in Primary Rat Neurons Exposed to Hypoxic-Ischemic-Like Injury In Vitro: Role of the Opioid System Scientists designed a study to reveal the therapeutic regimen and mechanism of action underlying hypothermia treatment in combination with stem cell transplantation for ameliorating neonatal hypoxic-ischemic-like injury. [PLoS One] Full Article Comparative Analysis of Mesenchymal Stem Cells from Adult Mouse Adipose, Muscle, and Fetal Muscle Investigators focused on the differences of mesenchymal stem cells from adult adipose, skeletal muscle and fetal muscle in biological characteristics, which is the key to cell therapy success. [Mol Biol Rep] Abstract | Full Article In Vitro Chondrogenesis by BMP6 Gene Therapy The promotion of in vitro chondrogenesis was investigated by using chitosan scaffolds and rat bone marrow-derived mesenchymal stem cells which are transfected by BMP6 (bone morphogenetic protein-6) encoding gene. [J Biomed Mater Res A] Abstract |