The Potential Role of Epigenetics on Multipotent Cell Differentiation Capacity of Mesenchymal Stromal Cells Investigators found that human umbilical cord perivascular cells exhibited increased telomerase activity and longer telomeres compared with bone marrow mesenchymal stromal cells. [Stem Cells] Abstract Mesenchymal Stem Cells Promote Growth and Angiogenesis of Tumors in Mice Using a xenograft model, human colorectal cancer cells, mesenchymal stem cells, and their cell mixture were introduced to a subcutaneous site of immunodeficient mice. The tumor growth rate and angiogenesis of each transplantation was then compared. [Oncogene] Abstract Isolation of Osteoprogenitors from Human Jaw Periosteal Cells: A Comparison of Two Magnetic Separation Methods To isolate osteoprogenitor cells from heterogeneous cell populations, scientists used the specific mesenchymal stem cell antigen-1 antibody and compared two magnetic separation methods. [PLoS One] Full Article Osteopontin Promotes Mesenchymal Stem Cell Migration and Lessens Cell Stiffness via Integrin β1, FAK, and ERK Pathways Researchers found that osteopontin activated focal adhesion kinase (FAK) and extracellular signal-regulated kinase (ERK) signaling pathways by the ligation of integrin β1 in rat bone marrow-derived mesenchymal stem cells. [Cell Biochim Biophys] Abstract | Full Article Pre-Treatment with IL-1β Enhances the Efficacy of MSC Transplantation in DSS-Induced Colitis Investigators focused on the therapeutic efficacy of interleukin-1β (IL-1β)-primed mesenchymal stem cells (MSCs) in the dextran sulfate sodium (DSS)-induced colitis model, in addition to the underlining mechanisms. [Cell Mol Immunol] Abstract Differential Expression of AURKA and AURKB Genes in Bone Marrow Stromal Mesenchymal Cells of Myelodisplastic Syndrome: Correlation with G-Banding Analysis and FISH Scientists found that AURKA mRNA was expressed at significantly higher levels in mesenchymal stem cells even with normal/altered karyotype when compared with hematopoietic cells and healthy donors. [Exp Hematol] Abstract An Orthopedic Tissue Adhesive for Targeted Delivery of Intraoperative Biologics Researchers introduced the application of the biomaterial chondroitin sulfate succinimidyl succinate to deliver intraoperative biologics in a hydrogel adhesive. They demonstrated the biomaterial’s ability to bind various tissue types and its cellular biocompatibility with encapsulated human mesenchymal stem cells. [J Orthop Res] Abstract In Vitro Assessment of Mesenchymal Stem Cells Immunosuppressive Potential in Multiple Sclerosis Patients Using an in vitro model of lymphocytes and mesenchymal stem cells (MSC) cocultivation investigators revealed that the Index of MSC Suppression of myelin-induced memory T cells proliferation was stronger than that of PHA-stimulated proliferation and inversely correlated with patients’ EDSS score. [Immunol Lett] Abstract Comparison of Tenocytes and Mesenchymal Stem Cells Seeded on Biodegradable Scaffolds in a Full-Size Tendon Defect Model In order to investigate cell-based tendon regeneration, a tendon rupture was simulated by utilizing a critical full-size model in female rat achilles tendons. For bridging the defect, polyglycol acid and collagen type I scaffolds were used and fixed with a frame suture to ensure postoperatively a functional continuity. Scaffolds were seeded with mesenchymal stem cells or tenocytes derived from male animals, while control groups were left without cells. [J Mater Sci Mater Med] Abstract | Full Article |