Bone Marrow-Mesenchymal Stem Cells Are a Major Source of Interleukin-7 and Sustain Colitis by Forming the Niche for Colitogenic CD4 Memory T Cells Researchers demonstrated that bone marrow (BM) mesenchymal stem cells are a major source of interleukin-7 and play a pathological role in inflammatory bowel disease by forming the niche for colitogenic CD4 memory T cells in BM. [Gut] Abstract Cell Surface Structures Influence Lung Clearance Rate of Systemically Infused Mesenchymal Stromal Cells Investigators found a striking difference in the lung clearance rate of systemically infused mesenchymal stromal/stem cell derived from two different clinical sources, namely bone marrow and umbilical cord blood. [Stem Cells] Abstract Electrospun Biomimetic Scaffold of Hydroxyapatite/Chitosan Supports Enhanced Osteogenic Differentiation of mMSCs Biomimetic composite nanofibrous scaffolds of hydroxyapatite/chitosan were prepared to investigate their capacity for inducing murine mesenchymal stem cells (mMSCs) to differentiate into the osteogenic lineage, in the absence and presence of an osteogenic supplementation, respectively. [Nanotechnology] Abstract Mesenchymal Stem Cells from Patients to Assay Bone Graft Substitutes Non-stoichiometric Mg2+ ions and stoichiometric apatites, which are used in orthopedic surgery as bone substitutes, have been assayed in vitro with human adult mesenchymal stem cells to evaluate cytocompatibility and osteoconductivity. [J Cell Physiol] Abstract Differentiation within Autologous Fibrin Scaffolds of Porcine Dermal Cells with the Mesenchymal Stem Cell Phenotype Researchers attempted to characterize the mesenchymal stem cell phenotype of porcine dermal cells and to evaluate their cellular proliferation and differentiation in autologous fibrin scaffolds. [Exp Cell Res] Abstract Human Adipose CD34+ CD90+ Stem Cells and Collagen Scaffold Constructs Grafted In Vivo Fabricate Loose Connective and Adipose Tissues Scientists examined mesenchymal stem cells co-expressing CD34 and CD90 from adipose tissue. This stem cell population displayed higher proliferative capacity than CD34– CD90– cells and was able to differentiate in vitro into adipocytes (PPARγ+ and adiponectin+) and endothelial cells (CD31+ VEGF+ Flk1+). [J Cell Biochem] Abstract Long Term Reparative Effects of Mesenchymal Stem Cell Therapy following Neonatal Hyperoxia-Induced Lung Injury Researchers evaluated whether the long term reparative effects of a single intra-tracheal dose of mesenchymal stem cells (MSCs) or MSC-conditioned medium are comparable in established hyperoxia-induced lung injury. [Pediatr Res] Abstract | Full Article Growth and Osteogenic Differentiation of Alveolar Human Bone Marrow-Derived Mesenchymal Stem Cells on Chitosan/Hydroxyapatite Composite Fabric Biological in vitro evaluations showed that human mesenchymal stem cells cultured on chitosan (CS)/hydroxyapatite fabric showed increased proliferation compared to those cultured on pure CS fabric, which was observed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, DNA content assay, and [3H] thymidine incorporation assay. [J Biomed Mater Res A] Abstract Effects of Rehmannia Glutinosa Oligosaccharide on Human Adipose-Derived Mesenchymal Stem Cells In Vitro Scientists evaluated the influence of Rehmannia glutinosa Oligosaccharide, a traditional Chinese medicine, on the proliferation of human adipose-derived mesenchymal stem cells, H2O2-induced apoptosis, and secretion of vascular endothelial growth factor and hepatocyte growth factor in vitro. [Life Sci] Abstract Wnt/β-Catenin Signaling Induces the Aging of Mesenchymal Stem Cells through Promoting ROS Production Researchers report that the Wnt/β-catenin signaling was a potent activator of reactive oxygen species generation in mesenchymal stem cells. [Mol Cell Biochem] Abstract |