Mesenchymal Cell News Volume 4.48 | Dec 4 2012

Complete Regression of Metastatic Renal Cell Carcinoma by Multiple Injections of Engineered Mesenchymal Stem Cells Expressing Dodecameric TRAIL and HSV-TK
Mesenchymal stem cells (MSCs) were engineered to coexpress dodecameric TNF-related apoptosis-inducing ligand and herpes simplex virus thymidine kinase (MSC/dTRAIL-TK). The antitumor effects of MSCs expressing dTRAIL or HSV-TK alone and MSC/dTRAIL-TK were compared on murine renal cell carcinoma cells using in vitro co-culture system and in vivo experimental lung metastasis model. [Clin Cancer Res] Abstract

High Levels of EphrinB2 Over-Expression Increases the Osteogenic Differentiation of Human Mesenchymal Stem Cells and Promotes Enhanced Cell Mediated Mineralization in a Polyethyleneimine-EphrinB2 Gene-Activated Matrix
The use of polyethyleneimine to transfect human mesenchymal stem cells (hMSCs) with ephrinB2 was assessed. Recently a role for the ephrinB2 ligand and EphB4 receptor duo has been proposed in bone remodeling. Over-expression of the ephrinB2 ligand resulted in increased osteogenic differentiation in hMSCs. [J Control Release] Abstract

Long-Term Functional Engraftment of Mesenchymal Progenitor Cells in a Mouse Model of Accelerated Aging
To investigate the role of mesenchymal progenitor cell aging as a cell-autonomous mechanism in senile bone loss, transplantation of young wild-type whole bone marrow into Wrn^−/−Terc^−/− mutants was performed and the ability of engrafted cells to differentiate into cells of the osteoblast lineage was assessed. [Stem Cells] Abstract

Sulfated Hyaluronan Containing Collagen Matrices Enhance Cell-Matrix-Interaction, Endocytosis, and Osteogenic Differentiation of Human Mesenchymal Stromal Cells
The authors applied quantitative proteomics to investigate the influence of artificial extracellular matrix composed of collagen type I and hyaluronan or sulfated hyaluronan on the molecular adaptation of osteogenic-differentiated human mesenchymal stromal cells. [J Proteome Res] Abstract

Systemic Administration of Human Adipose-Derived Stem Cells (hASCs) Reverts Nociceptive Hypersensitivity in an Experimental Model of Neuropathy
Scientists investigated the effect of hASCs injected in a model of neuropathic pain (mouse sciatic nerve chronic constriction injury). hASCs from five donors were characterized, and no major differences were depicted. [Stem Cell Dev] Abstract

Mesenchymal Stem Cells Overexpressing CXCR4 Improve Early Liver Regeneration of Small-for-Size Liver Grafts
The authors investigated whether CXCR4-mesenchymal stem cell infusion protects hepatocytes and stimulates regeneration in 50% reduced-size liver transplantation. [Liver Transplant] Abstract

Polyphenols Suppress Hydrogen Peroxide-Induced Oxidative Stress in Human Bone-Marrow Derived Mesenchymal Stem Cells
Scientists carried out a systematic analysis of the effects of polyphenols on human mesenchymal stem cell in their response to oxidative stress in the form of treatment with H₂O₂ and nitroso-N-acetylpenicillamine, respectively. [J Cell Biochem] Abstract

Gefitinib Inhibits the Cross-Talk between Mesenchymal Stem Cells and Prostate Cancer Cells Leading to Tumor Cell Proliferation and Inhibition of Docetaxel Activity
Investigators showed that treatment of human primary mesenchymal stem cells with conditioned medium derived from the bone metastatic PC3 carcinoma cells resulted in a significant activation of epidermal growth factor receptor, increased proliferation, increased osteoblastic but decreased adipocitic differentiation, inhibition of senescence induced by serum starvation and increased CCL5 secretion. [J Cell Biochem] Abstract

Chondrogenic Differentiation of Bone Marrow-Derived Mesenchymal Stromal Cells via Biomimetic and Bioactive Poly-ε-Caprolactone Scaffolds
The authors aimed to develop a scaffold for mesenchymal stromal cell recruitment, proliferation, and chondrogenic differentiation. [J Biomed Mater Res] Abstract

REVIEWS

American CryoStem Corporation and XeoStem LLC Complete Adipose Stem Cell Processing and Tissue Banking Agreement
American CryoStem Corporation (CRYO) announced that it has entered into an agreement with XeoStem LLC of Coral Gables, FL in which CRYO will provide its proprietary adipose tissue processing and storage services. [American CryoStem Corporation] Press Release

Stem Cell Pioneer Recognized for 20 Years of Discovery and Innovation
Dr. David Harris, Professor of Immunology at the University of Arizona and a scientific pioneer in the field of stem cell banking, was the recipient of the Arizona BioIndustry Association™ 2012 award for “20 Years of Discovery and Innovation”. [Adicyte, Inc.] Press Release

National Institutes of Health (United States)

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Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW 17th Annual Hilton Head Workshop: Regenerative Medicine – Technologies Enabling Novel Therapies
March 20-23, 2013
Hilton Head Island, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.

Product Quality Scientist (STEMCELL Technologies, Inc.)

Scientist – Endothelial Cell Research (STEMCELL Technologies, Inc.)

Research Technologist – Cell Separation (STEMCELL Technologies, Inc.)

Scientist or Engineer – hPSC Bioengineer (STEMCELL Technologies, Inc.)

Quality Control Analyst (STEMCELL Technologies, Inc.)

Postdoctoral Position – Tumorigenicity of Mesenchymal Stem Cells Department of Molecular Cell Biology (Weizmann institute of Science)

Postdoctoral Position – Tumor Stem Cells (Cancer Institute of New Jersey)

Postdoctoral Position – Osteogenic Differentiation of Mesenchymal Stem Cells (University of Connecticut Health Center)

Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

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