Injectable Bone Tissue Engineering Using Expanded Mesenchymal Stem Cells Scientists investigated whether injectable tissue-engineered bone composed of mesenchymal stem cells and platelet rich plasma was able to regenerate functional bone in alveolar deficiencies. [Stem Cells] Abstract Characterization of Mesenchymal Stem Cell Subpopulations from Human Amniotic Membrane with Dissimilar Osteoblastic Potential Researchers aimed to isolate homogeneous amniotic membrane human fetal mesenchymal stem cells subpopulations based on the co-expression of surface markers. [Stem Cell Dev] Abstract A Soluble G-CSF Decoy Receptor as a Novel Tool to Increase Hematopoietic Cell Homing and Reconstitution in Mice The authors provide evidences that homing is severely impaired post exposure to ionizing radiation in mice, an effect they found was time-dependent and could be partially rescued using mesenchymal stromal cell therapy. [Stem Cell Dev] Abstract Human Serum Promotes Osteogenic Differentiation of Human Dental Pulp Stem Cells In Vitro and In Vivo Scientists demonstrated that human serum is a suitable alternative to fetal calf serum; indeed its addition to culture medium induces a high human dental pulp stem cell proliferation rate and improves the in vitro osteogenic differentiation. [PLoS One] Full Article Compression-Induced Alignment and Elongation of Human Mesenchymal Stem Cell (hMSC) in 3D Collagen Constructs Is Collagen Concentration Dependent The authors investigated the collagen concentration dependence of the compression-induced hMSC organization. Results demonstrated that the compression-induced alignment and elongation of hMSCs exhibited a biphasic dose-dependent relationship with collagen concentration, and associated well with both collagen ligand density and elastic modulus of the constructs. [J Biomed Mater Res A] Abstract Efficacy of Mesoporous Silica Nanoparticles in Delivering BMP-2 Plasmid DNA for In Vitro Osteogenic Stimulation of Mesenchymal Stem Cells Researchers report the ability of aminated mesoporous silica nanoparticles with large mesopore space and positive-charged surface to deliver genes within rat mesenchymal stem cells (MSCs). The amine functionalized inorganic nanoparticles were complexed with bone morphogenetic protein-2 (BMP-2) plasmid DNA to study their transfection efficiency in MSCs. [J Biomed Mater Res A] Abstract Novel Application of Stem Cell-Derived Factors for Periodontal Regeneration The effect of conditioned medium from cultured mesenchymal stem cells (MSC-CM) on periodontal regeneration was evaluated. In vitro, MSC-CM stimulated migration and proliferation of dog MSCs and dog periodontal ligament cells. [Biochem Biophys Res Commun] Abstract Human Mesenchymal Stem Cells Reduce Lung Injury in Immunocompromised Mice but Not in Immunocompetent Mice The authors compared the efficacy of human mesenchymal stem cells in preventing bleomycin-induced lung injury in immunocompromised SCID and immunocompetent C57Bl/6 mice. [Respiration] Abstract |