Superparamagnetic Iron Oxide Nanoparticle Targeting of MSCs in Vascular Injury Scientists showed that magnetic targeting of mesenchymal stem cells (MSCs) gives rise to a six-fold increase in cell retention following balloon angioplasty in a rabbit model using a clinically applicable permanent magnet. [Biomaterials] Abstract Mesenchymal Stem Cell-Based Cell Engineering with Multifunctional Mesoporous Silica Nanoparticles for Tumor Delivery The authors describe a mesenchymal stem cell-based multifunctional platform to target orthotopic glioblastoma by integrating the tumor targeted delivery of mesenchymal stem cells and the multimodal imaging advantage of mesoporous silica nanoparticles. [Biomaterials] Abstract Short-Term, Long-Term and Paracrine Effect of Human Umbilical Cord-Derived Stem Cells in Lung Injury Prevention and Repair in Experimental Bronchopulmonary Dysplasia Researchers observed that human umbilical cord-derived perivascular cells and mesenchymal stem cells exerted short- and long-term therapeutic benefit without adverse lung effects in rat pups exposed to hyperoxia, a well-established bronchopulmonary dysplasia model, and offer new therapeutic options for lung diseases characterized by alveolar damage. [Thorax] Abstract | Press Release Control Over the Gradient Differentiation of Rat BMSCs on a PCL Membrane with Surface-Immobilized Alendronate Gradient A linear density gradient of alendronate, a molecule that is capable of promoting osteogenic differentiation of bone mesenchymal stem cells (BMSCs), was created on the aminolyzed poly(ε-caprolactone) (PCL) membrane. [Biomacromolecules] Abstract Induction of Mesenchymal Stem Cell Chondrogenesis by Polyacrylate Substrates The authors investigated whether polyacrylate substrates modeled on the functional group composition and distribution of the RGD integrin-binding site could induce mesenchymal stem cells to undergo chondrogenesis in the absence of exogenous transforming growth factor beta. [Acta Biomater] Abstract Umbilical Cord Blood-Derived Mesenchymal Stem Cells Inhibit, but Adipose Tissue-Derived Mesenchymal Stem Cells Promote Glioblastoma Multiforme Proliferation To examine the anticancer therapeutic application of mesenchymal stem cells (MSC) from different sources, researchers established two different kinds of human MSC: umbilical cord blood-derived MSC and adipose tissue-derived MSC. They used these MSC in a co-culture assay with primary glioblastoma multiforme (GBM) cells to analyze how MSC from different sources can inhibit GBM growth. [Stem Cells Dev] Abstract The Effect of Link N on Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells Scientists aimed to determine how Link N may influence human mesenchymal stem cell (MSC) differentiation, as a prelude to using Link N and MSC supplementation in unison for optimal repair of the degenerated disc. [Arthritis Res Ther] Abstract | Full Article Selective Development of Myogenic Mesenchymal Cells from Human Embryonic and Induced Pluripotent Stem Cells The authors aimed to establish a practical differentiation method to induce skeletal myogenesis from both human embryonic stem and induced pluripotent stem cells. To accomplish this goal, they developed a novel stepwise culture method for the selective expansion of mesenchymal cells from cell aggregations called embryoid bodies. [PLoS One] Full Article Effect of Lumican on the Migration of Human Mesenchymal Stem Cells and Endothelial Progenitor Cells: Involvement of Matrix Metalloproteinase-14 Researchers aimed to analyze the role of lumican in the control of mesenchymal stem cell migration and transition to functional endothelial progenitor cell. [PLoS One] Full Article |