Mesenchymal Cell News Volume 5.03 | Jan 29 2013

TSG-6 Produced by hMSCs Delays the Onset of Autoimmune Diabetes by Suppressing Th1 Development and Enhancing Tolerogenicity
Scientists showed that human mesenchymal stem/stromal cells (hMSCs) and TNF-α-stimulated gene 6 (TSG-6), a protein produced by hMSCs in response to signals from injured tissues, delayed the onset of spontaneous autoimmune diabetes in NOD mice by inhibiting insulitis and augmenting regulatory T cells within the pancreas. [Diabetes] Abstract

Timing of Umbilical Cord Blood Derived Mesenchymal Stem Cells Transplantation Determines Therapeutic Efficacy in the Neonatal Hyperoxic Lung Injury
The authors aimed to optimize the timing of mesenchymal stem cells transplantation. Newborn Sprague-Dawley rats were randomly exposed to hyperoxia or normoxia after birth for 21 days. [PLoS One] Full Article

Hypoxia Promotes Dopaminergic Differentiation of Mesenchymal Stem Cells and Shows Benefits for Transplantation in a Rat Model of Parkinson’s Disease
Intratracheal transplantation of human umbilical cord blood derived mesenchymal stem cells (MSCs) time-dependently attenuated hyperoxia-induced lung injury in neonatal rats, showing significant protection only in the early but not in the late phase of inflammation. There were no synergies with combined early+late MSCs transplantation. [PLoS One] Full Article

Scaffold Effects on Osteogenic Differentiation of Equine Mesenchymal Stem Cells: An In Vitro Comparative Study
The in vitro viability, osteogenic differentiation, and mineralization of four different equine mesenchymal stem cells from bone marrow, periosteum, muscle, and adipose tissue were compared, when they were cultured with different collagen-based scaffolds or with fibrin glue. [Macromol Biosci] Abstract

Optimizing Patient Derived Mesenchymal Stem Cells as Virus Carriers for a Phase I Clinical Trial in Ovarian Cancer
Mesenchymal stem cells from adipose tissues of healthy donors and nine ovarian cancer patients were characterized for susceptibility to virus infection and tumor homing abilities. [J Trans Med]
Abstract | Full Article

Cartilage Regeneration by Selected Chondrogenic Clonal Mesenchymal Stem Cells in the Collagenase-Induced Monkey Osteoarthritis Model
Researchers evaluated the repair potential of selected chondrogenic clonal mesenchymal stem cells by delivering them into the injured cartilage site in a collagenase-induced osteoarthritis model in Cynomolgus monkeys. [J Tissue Eng Regen Med] Abstract

Intratracheal Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Inhibits the Development of Airway Remodeling and Reduces the Airway Inflammation in Chronic Asthma
Previous studies proved that bone marrow-derived mesenchymal stem cells (BMSCs) could improve a variety of immune-mediated disease by its immunomodulatory properties. In this study, the authors investigated the effect on airway remodeling and airway inflammation by administrating BMSCs in chronic asthmatic mice. [J Cell Biochem] Abstract

Low Oxygen Tension Maintains Multipotency, whereas Normoxia Increases Differentiation of Mouse Bone Marrow Stromal Cells
Scientists isolated mouse bone marrow stromal cells (BMSC) and showed that they contained a population meeting requirements for mesenchymal stem cell definition. In order to establish the effect of low O₂ on cellular properties, they examined BSMC cultured under hypoxic conditions. [Int J Mol Sci]
Abstract | Full Article

Generation of a Human Bone Marrow-Derived Mesenchymal Stem Cell Line Expressing and Secreting High Levels of Bioactive α-Melanocyte-Stimulating Hormone
α-Melanocyte-stimulating hormone (α-MSH) functions as a mediator of inflammation and immunity; however, the short half-life and high dose needed limit the comprehensive clinical application of α-MSH. Researchers generated human bone marrow-derived mesenchymal stem cells that express and secrete high levels of bioactive α-MSH. [J Biochem] Abstract

REVIEWS

Rush Researchers Studying Stem Cell Therapy to Repair Damaged Knee Cartilage
Rush University Medical Center is conducting the nation’s first clinical study of an innovative stem cell drug, Cartistem, to repair knee cartilage damaged by aging, trauma or degenerative diseases such as osteoarthritis. Cartistem is manufactured from mesenchymal stem cells derived from allogeneic umbilical cord blood. [Rush University Medical Center] Press Release

Vitro Biopharma Launches New Stem Cell Products to Accelerate Bone Growth
Vitro Diagnostics, Inc. announced the launch of a series of products with application to accelerated bone growth, fracture healing and development of new osteoporosis drugs. The new products are osteoblasts derived from human adult stem cells known as mesenchymal stem cells. [MarketWatch Inc.] Press Release

IntelliCell BioSciences Receives Notice of Allowance for Its US Patent for “Ultrasonic Cavitation of Adipose Tissue to Produce Stromal Vascular Fraction Regenerative Cells”
IntelliCell BioSciences, Inc. announced that on January 17, 2013 the company received a notice of allowance regarding its U.S. Patent Application Serial No. 13/323,030 entitled “Ultrasonic Cavitation of Adipose Tissue to Produce Stromal Vascular Fraction Regenerative Cells.” The allowed claims apply to IntelliCell’s proprietary method for deriving blood vessel originated vascular cells from adipose (fat) tissue by use of ultrasonic cavitation. [PR Newswire Association LLC] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW The 3^rd International Congress on Controversies in Cryopreservation of Stem Cells, Reproductive Cells, Tissue and Organs (CRYO)
March 21-23, 2013
Berlin, Germany

Visit our events page to see a complete list of events in the mesenchymal cell community.

Postdoctoral Position – Tumorigenicity of Mesenchymal Stem Cells (Weizmann Institute of Science)

PhD Student – Stem Cells in Tooth Regeneration (King’s College London)

Postdoctoral Position – Mouse Developmental Biology (Lund Stem Cell Center, Lund University)

Postdoctoral Position – Stem Cell Biology (Johns Hopkins School of Medicine)

Postdoctoral Position – Human Stem Cell Engineering (University of Wisconsin – Madison)

Postdoctoral Position – Mesenchymal Cell Function in Chronic Lung Disease (German Research Center for Environmental Health)

Postdoctoral Position – Myeloproliferative Neoplasms (Mount Sinai Medical Center)

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