miR-126 and miR-126* Repress Recruitment of Mesenchymal Stem Cells and Inflammatory Monocytes to Inhibit Breast Cancer Metastasis Investigators report that miR-126/miR-126*, a microRNA pair derived from a single precursor, independently suppress the sequential recruitment of mesenchymal stem cells and inflammatory monocytes into the tumor stroma to inhibit lung metastasis by breast tumor cells in a mouse xenograft model. [Nat Cell Biol] Abstract Nanotopographical Cues Augment Mesenchymal Differentiation of Human Embryonic Stem Cells Using planar polycarbonate substrates lacking in topographical cues and substrates displaying a nanotopographical pattern, mesenchymal differentiation of human embryonic stem cells is directed in the absence of chemical factors and without induction of differentiation by embryoid body formation. Cells incubated on nanotopographical substrates show enhanced expression of mesenchymal or stromal markers and expression of early osteogenic progenitors at levels above those detected in cells on planar substrates in the same basal media. [Small] Abstract | Press Release In Vivo Imaging of the Therapeutic Efficacy and Fate of Bimodal Engineered Stem Cells in Malignant Brain Tumors Researchers developed an efficient stem cell based therapeutic strategy that simultaneously allows killing of tumor cells and assessment and eradication of stem cells post highly malignant glioblastoma multiforme (GBM) brain tumor treatment. Mesenchymal stem cells (MSC) engineered to co-express the prodrug converting enzyme, herpes simplex virus thymidine kinase and a potent and secretable variant of tumor necrosis factor apoptosis-inducing ligand induced caspase mediated GBM cell death and showed selective MSC sensitization to the prodrug ganciclovir. [Stem Cells] Abstract Diverse Functions of Secreted Frizzled-Related Proteins in the Osteoblastogenesis of Human Multipotent Mesenchymal Stromal Cells Osteoinductive pretreatment of human mesenchymal stromal cells (hMSCs) has been widely accepted in bone tissue engineering before the use of cell transplantation; however, the mechanisms by which osteoinductive medium enhances osteoblastic differentiation are not well understood. Using periodontal ligament-derived hMSCs, researchers identified key signaling molecules for osteoblastogenesis. [Biomaterials] Abstract Mesenchymal Stem Cells Induce Granulocytic Differentiation of Acute Promyelocytic Leukemic Cells via IL-6 and MEK/ERK Pathways The authors report that human umbilical cord-derived mesenchymal stem cells are capable of inducing granulocytic differentiation of acute promyelocytic leukemia (APL)-derived NB4 cell line as well as primary APL cells and also cooperate with all-trans retinoic acid in an additive manner. [Stem Cells Dev] Abstract Growth Differentiation Factor-5 Enhances In Vitro Mesenchymal Stromal Cell Chondrogenesis and Hypertrophy Supplementation of chondrogenic mesenchymal stromal cell (MSC) pellet cultures with growth differentiation factor-5 (GDF-5), a highly regulated gene in the chondrogenic phase of endochondral ossification was investigated here under the hypothesis that GDF-5 will enhance the chondrogenic differentiation of MSCs, thereby supporting their entry into ossification. [Stem Cells Dev] Abstract Co-Transplantation of Third-Party Umbilical Cord Blood-Derived MSCs Promotes Engraftment in Children Undergoing Unrelated Umbilical Cord Blood Transplantation Success of umbilical cord blood transplantation (UCBT) has been limited by a high rate of graft failure and delayed hematological recovery. It has been postulated that MSCs have hematopoiesis-supportive properties. Therefore, to overcome the limitation of UCBT, third-party UCB-derived MSCs were co-transplanted in recipients receiving unrelated UCBT. [Bone Marrow Transplant] Abstract Adipose Tissue-Derived Mesenchymal Stem Cells Efficiently Differentiate into Insulin-Producing Cells in Pancreatic Islet Microenvironment Both In Vitro and In Vivo The differentiation of mesenchymal stem cells (MSCs) derived from rat tissues (adipose, rAT; bone marrow, rBM) were analyzed by in vitro and in vivo co-culture experiments. The insulin-producing capacities of islets transplanted under the renal kidney capsule with rAT- and rBM-MSCs were compared and the reduction of hyperglycemia symptoms in rat models was examined. [Cytotherapy] Abstract Transplantation-Potential-Related Biological Properties of Decidua Basalis Mesenchymal Stem Cells from Maternal Human Term Placenta Scientists obtained decidua-basalis-derived mesenchymal stem cells through enzymatic digestion and density gradient centrifugation and confirmed their capacity to differentiate into cell types of the mesodermal lineage, such as osteoblasts, adipocytes and chondroblasts. [Cell Tissue Res] Abstract Evaluation of Early Stage Human Bone Marrow Stromal Proliferation, Cell Migration and Osteogenic Differentiation on μ-MIM Structured Stainless Steel Surfaces Researchers previously showed that microstructured stainless steel surfaces characterized by the presence of defined hexagonally arranged hemisphere-like structures significantly affected cell architecture (shape and focal adhesion size) of primary human bone mesenchymal stromal cells. Here they further investigated the influence these microstructures (microcline protruding hemispheres) on critical aspects of cell behavior namely; proliferation, migration and osteogenic differentiation. [J Mater Sci Mater Med] Abstract |