Shockwaves Induce Osteogenic Differentiation of Human Mesenchymal Stem Cells through ATP Release and Activation of P2X7 Receptors Shockwave treatment promotes bone healing of non-union fracture. Researchers investigated whether this effect could be due to ATP release-induced differentiation of human mesenchymal stem cells (hMSCs) into osteoprogenitor cells. Cultured bone marrow-derived hMSCs were subjected to shockwave treatment and ATP release was assessed. [Stem Cells] Abstract | Full Article Platelet Lysate Coating on Scaffolds Enhances Directly and Indirectly Cell Migration Improving Bone and Blood Vessel Formation Investigators aimed to determine if the delivery of human mesenchymal stromal cells (hMSC) seeded on human platelet lysate-coated HA/βTCP scaffolds could enhance vascularization and bone formation, as well as to investigate the mechanisms by which hMSC participate to tissue regeneration. [Acta Biomater] Abstract Prospective Isolation of Mesenchymal Stem Cells from Human Bone Marrow Using Novel Antibodies Directed against Sushi Domain Containing 2 (SUSD2) Recently, the authors described the monoclonal antibodies W3D5 and W5C5, which selectively react with Bone Marrow derived Mesenchymal Stem/Stromal Cells (BM-MSCs) but not with hematopoietic cells. Both antibodies showed an identical reactivity pattern, indicating that they may recognize the same molecule. To identify the cognate antigen, cultured MSCs were sorted for cells expressing either very high levels of W5C5/W3D5 antigen or for cells which were negative for this antigen. [Stem Cell Dev] Abstract Stromal Targeting of Sodium Iodide Symporter Using Mesenchymal Stem Cells Allows Enhanced Imaging and Therapy of Hepatocellular Carcinoma Using a human hepatocellular cancer xenograft mouse model, scientists investigated distribution and tumor recruitment of RANTES-sodium iodide symporter-engineered mesenchymal stem cells after systemic injection by gamma camera imaging. [Hum Gen Ther] Abstract Lectin-Like Oxidized LDL Receptor-1 Expresses in Mouse Bone Marrow-Derived Mesenchymal Stem Cells and Stimulates their Proliferation Researchers investigated the status of Lectin-like oxidized low density lipoprotein (LDL) receptor-1 expression in bone marrow-derived mesenchymal stem cells (bmMSCs) and its function on bmMSC proliferation. [Exp Cell Res] Abstract Effects of Salinomycin on Human Bone Marrow-Derived Mesenchymal Stem Cells In Vitro Various hypotheses on the origin of cancer stem cells (CSCs) exist, including that CSCs develop from transformed human bone marrow mesenchymal stem cells (hBMSC). Since the polyether antibiotic salinomycin selectively kills CSCs, the authors aimed to elucidate the effects of salinomycin on normal hBMSC. [Toxicol Lett] Abstract Mesenchymal Stem Cells from Amnion and Amniotic Fluid in Bovine Scientists obtained and characterized, for the first time in bovine species, presumptive mesenchymal stem cells from the epithelial portion of the amnion and from the amniotic fluid to be used for clinical applications. [Reproduction] Abstract Electromagnetic Fields Induce Neural Differentiation of Human Bone Marrow Derived Mesenchymal Stem Cells via Reactive Oxygen Species Mediated Epidermal Growth Factor Receptor Activation To find out the signaling pathways involved in the neural differentiation of human bone marrow mesenchymal stem cells by electromagnetic fields, researchers examined the CREB phosphorylation and Akt or ERK activation as an upstream of CREB. [Neurochem Int] Abstract Human Adipose Tissue-Derived Mesenchymal Stem Cells Improve Cognitive Function and Physical Activity in Aging Mice Human adipose tissue-derived mesenchymal stem cells (ADMSCs) were intravenously or intracerebroventricularly transplanted into the brains of 18-month-old mice once or four times at two-week intervals. Transplantation of ADMSCs improved both locomotor activity and cognitive function in the aged animals, in parallel with recovery of acetylcholine levels in brain tissues. [J Neurosci Res] Abstract |