Mesenchymal Stem Cells Attenuate Ischemic Acute Kidney Injury by Inducing Regulatory T Cells through Splenocyte Interactions Investigators found that mesenchymal stem cells decrease serum creatinine and urea nitrogen levels, improve tubular injury, and downregulate IFN-γ production of T cells in the ischemic kidney. [Kidney Int] Full Article Mesenchymal Stem Cells from Periapical Lesions Modulate Differentiation and Functional Properties of Monocyte-Derived Dendritic Cells Using a model of monocyte-derived dendritic cells (DCs), investigators showed that periapical lesions-mesenchymal stem cells inhibited differentiation of DCs via soluble factors, of which IL-6 had a minor effect, but did not impair their subsequent maturation induced by pro-inflammatory cytokines. [Eur J Immunol] Abstract Myocilin Stimulates Osteogenic Differentiation of Mesenchymal Stem Cells through MAPK Signaling Researchers report that myocilin is expressed in bone marrow-derived mesenchymal stem cells (MSCs) and plays a role in their differentiation into osteoblasts in vitro and in osteogenesis in vivo. Expression of myocilin was detected in MSCs derived from mouse, rat and human bone marrow with human MSCs exhibiting the highest level of myocilin expression. [J Biol Chem] Abstract The Dual Effect of MSCs on Tumor Growth and Tumor Angiogenesis Scientists investigated the influence of human mesenchymal stem cells (hMSCs) on the growth of pre-established tumors. Regardless of the tumor model and mode of hMSC injection, hMSC administration was always associated with decreased tumor growth due to an inhibition of tumor cell proliferation, likely resulting from deep modifications of the tumor angiogenesis. [Stem Cell Res Ther] Abstract | Full Article | Press Release Exosomes Released by Human Umbilical Cord Mesenchymal Stem Cells Protect Against Cisplatin-Induced Renal Oxidative Stress and Apoptosis In Vivo and In Vitro Investigators focused on the protective effect of exosomes derived from human umbilical cord mesenchymal stem cells (hucMSC-ex) on cisplatin-induced nephrotoxicity in vivo and in vitro. In vitro, treatment with cisplatin alone in rat renal tubular epithelial (NRK-52E) cells resulted in an increase in the number of apoptosis cells, oxidative stress and activation of the p38MAPK pathway followed by a rise in the expression of caspase3, and a decrease in cell multiplication, while those results were reversed in the hucMSCs-ex treated group. [Stem Cell Res Ther] Abstract | Full Article Lipocalin-2-Mediated Upregulation of Various Antioxidants and Growth Factors Protects Bone Marrow-Derived Mesenchymal Stem Cells against Unfavorable Microenvironments The authors engineered mesenchymal stem cells (MSCs) with lipocalin 2 (Lcn2), a cytoprotective factor that is naturally induced following exposure of cells to stresses imposed by the microenvironment. Lcn2 overexpression not only did not interfere with the multidifferentiation capacity of the MSCs but also granted many protective properties to them. [Cell Stress Chaperon] Abstract Comparative Study of Three Types of Polymer Materials Co-Cultured with Bone Marrow Mesenchymal Stem Cells for Use as a Myocardial Patch in Cardiomyocyte Regeneration Scientists investigated the most suitable polymer material for supporting stem cell growth as a myocardial patch. After cell isolation and expansion of mouse bone marrow mesenchymal stem cells, the cells were induced to differentiate into cardiomyocytes with 5-azacytidine to determine their differentiation potential. The results revealed that cell numbers were more abundant on both the polyurethane and 3-hydroxybutyrate-co-4-hydroxybutyrate material surfaces. [J Mater Sci-Mater M] Abstract Cellular Interactions via Conditioned Media Induce In Vivo Nephron Generation from Tubular Epithelial Cells or Mesenchymal Stem Cells Under a novel concept of cellular interactions via conditioned media (CMs), researchers have attempted in vivo nephron generation from tubular epithelial cells (TECs) or mesenchymal stem cells (MSCs). Their findings suggest that the cellular interactions via CMs might induce in vivo nephron generation from TECs or MSCs. [Biochem Bioph Res Co] Abstract The Use of Hypoxic Cultured Mesenchymal Stem Cells for Oncolytic Virus Therapy Using an in vitro coculture with human colon cancer cells and with intraperitoneally and subcutaneously developed human colon cancer xenografts, researchers demonstrated that hypoxic mesenchymal stem cells are able to protect conditionally replicative adenoviruses from attack by preexisting neutralizing antibodies, thereby successfully delivering them to the target tumor cells. [Cancer Gene Ther] Abstract Self-Renewing Human Bone Marrow Mesenspheres Promote Hematopoietic Stem Cell Expansion Scientists describe a method of isolating and culturing human bone marrow stromal stem/progenitor cells as nonadherent mesenchymal spheres. Human mesenspheres were derived from CD45– CD31– CD71– CD146+ CD105+ nestin+ cells but could also be simply grown from fetal and adult BM CD45–-enriched cells. Human mesenspheres robustly differentiated into mesenchymal lineages. 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