Mesenchymal Cell News Volume 5.18 | May 14 2013

Abi3bp Is a Multifunctional Autocrine/Paracrine Factor that Regulates Mesenchymal Stem Cell Biology
Scientists investigated the relevance of Abi3bp towards mesenchymal stem cells biology. Abi3bp formed extracellular deposits with expression controlled by Akt1 and ubiquitin-mediated degradation. [Stem Cells] Abstract

Human Mesenchymal Stem Cells Overexpressing the IL-33 Antagonist sST2 Attenuate Endotoxin-Induced Acute Lung Injury
Investigators engineered human adipose tissue-derived mesenchymal stem cells overexpressing sST2, a decoy receptor for IL-33, aimed to enhance their immunoregulatory and anti-inflammatory properties when applied in a murine acute lung injury (ALI) model. [Am J Resp Cell Mol] Abstract

In Vitro Evidence of the Presence of Mesenchymal Stromal Cells in Cervical Cancer and Their Role in Protecting Cancer Cells from Cytotoxic T Cell Activity
Scientists report on the presence of mesenchymal stromal cells (MSCs) in cervical tissue, both in normal conditions and in cervical cancer, and describe several biological properties of such cells. Their study showed similar patterns of cell surface antigen expression, but distinct differentiation potentials, when they compared both cervical MSCs populations to MSCs from normal bone marrow. [Stem Cells Dev] Abstract

Similar Properties of Chondrocytes from Osteoarthritis Joints and Mesenchymal Stem Cells from Healthy Donors for Tissue Engineering of Articular Cartilage
Patients with osteoarthritis (OA) may require tissue engineered cartilage therapy. Chondrocytes obtained from OA joints are thought to be involved in the disease process, and thus to be of insufficient quality to be used for repair strategies. Bone marrow derived mesenchymal stem cells from healthy donors may represent an alternative cell source. Scientists isolated chondrocytes from OA joints, performed cell culture expansion and tissue engineering of cartilage using a disc-shaped alginate scaffold and chondrogenic differentiation medium. [PLoS One] Full Article

Comparison of Treatments of Peripheral Arterial Disease with Mesenchymal Stromal Cells and Mesenchymal Stromal Cells Modified with Granulocyte and Macrophage Colony-Stimulating Factor
Mesenchymal stromal cells (MSCs) have an important role in neovasculogenesis during ischemia because they release pro-angiogenic paracrine factors, pro-survival and immunomodulatory substances and can differentiate into endothelial cells. Researchers evaluated whether there is synergy between granulocyte macrophage-colony stimulating factor and MSCs in recovering ischemic limbs. [Cytotherapy] Full Article

T Cell Subsets Differently Regulate Osteogenic Differentiation of Human Mesenchymal Stromal Cells In Vitro
Scientists sought to analyze the osteogenic gene expression profile of whole T cells, CD4 and CD8 T cells isolated from healthy donors and investigated whether secreted factors from each group modulate osteogenic differentiation of human mesenchymal stem cells. [J Tissue Eng Regen M] Abstract

Cell-Cell Interaction between Vocal Fold Fibroblasts and Bone Marrow Mesenchymal Stromal Cells in Three-Dimensional Hyaluronan Hydrogel
By using an in vitro three-dimensional co-culture assay of normal or scarred human vocal fold fibroblasts (VFFs) and bone marrow-derived MSCs (BM-MSCs) in a uniquely suited hyaluronan hydrogel, researchers investigated cell morphology, survival rate, proliferation and protein and gene expression of VFFs and BM-MSCs. BM-MSCs inhibited cell proliferation of both normal and scarred VFFs without changes in VFF morphology or viability. [J Tissue Eng Regen M] Abstract

Improved hMSC Functions on Titanium Coatings by Type I Collagen Immobilization
Human mesenchymal stem cells (hMSCs) were used to evaluate the cytocompatibility of modified titanium coatings. Type I collagen immobilized on titanium coating led to enhance cell-material interactions and improved hMSC functions, such as attachment, proliferation, and differentiation. [J Biomed Mater Res A] Abstract

Polyglycolic Acid-Hyaluronan Scaffolds Loaded with Bone Marrow-Derived Mesenchymal Stem Cells Show Chondrogenic Differentiation In Vitro and Cartilage Repair in the Rabbit Model
In cartilage repair, scaffold-assisted one-step approaches are used to improve the microfracture technique. Researchers analyzed the chondrogenic potential of freeze-dried polyglycolic acid-hyaluronan implants preloaded with mesenchymal stem cells in vitro and in a rabbit articular cartilage defect model. [J Biomed Mater Res B] Abstract

Adenosine A₁ Receptor Stimulation Enhances Osteogenic Differentiation of Human Dental Pulp-Derived Mesenchymal Stem Cells via WNT Signaling
Scientists observed that mesenchymal stem cells deriving from dental pulp, undifferentiated or submitted to osteogenic differentiation, express all four subtypes of adenosine receptors (AR) and CD73, corresponding to 5′-ecto-nucleotidase, and AR stimulation with selective agonists elicited a greater osteogenic cell differentiation consequent to A1 receptor activation. [Stem Cell Res] Abstract

REVIEWS

Endogenous Morphogens and Fibrin Bioscaffolds for Stem Cell Therapeutics
This paper reviews the state of the art of platelet-rich plasma technology applied to clinical use of stem cells, focusing on current technology and methods, new challenges, and controversies. [Trends Biotech] Abstract

Adult Stem Cells for Chronic Lung Diseases
In this review, the authors discuss the repair response of bone marrow derived mesenchymal stem cells after lung injury and how their function is affected by aging. [Respirology] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Stem Cell Research for New MS Treatment
Modified adult stem cells may hold the key to a new treatment for multiple sclerosis (MS), according to researchers, speaking during ‘Kiss Goodbye to MS’ month. They have started a three-year research project using adult stem cells from fat tissue to send cells with special anti-inflammatory properties directly to the damaged site in the central nervous system. [University of Adelaide] Press Release

NeoStem’s Subsidiary, Progenitor Cell Therapy, to Provide Autologous and Allogeneic Cellular Therapy Services to MedStar Georgetown University Hospital
NeoStem, Inc. and its subsidiary, Progenitor Cell Therapy, LLC (PCT) announced that PCT has entered into a Cell Therapy Processing Customer Agreement with MedStar Georgetown University Hospital to provide autologous and allogeneic cellular therapy services for cellular products provided by MedStar Georgetown University Hospital (MGUH) and deliver resulting cellular therapy products to MGUH for patient care. [NeoStem, Inc.] Press Release

Pioneering Researchers Recognized for Scientific Achievements in Gene and Cell Therapy
The American Society of Gene & Cell Therapy (ASGCT) is honored to recognize Dr. Sonia Skarlatos, PhD, and Dr. Catherine McKeon, PhD as the recipients of the Distinguished Service Award. This award recognizes an ASGCT Member or group that has consistently fostered and enhanced the field of genetic and cellular therapy. [American Society of Gene & Cell Therapy] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW Gordon Research Seminar – Biomaterials & Tissue Engineering
July 27-28, 2013
Holderness, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.

NEW Postdoctoral Research Scientist – Regenerative Stem Cell Research (NHS Blood and Transplant)

Postdoctoral Fellow (Johns Hopkins University School of Medicine)

Postdoctoral Opportunity – Pulmonary Research (Cedars-Sinai Medical Center)

Researcher – Mesenchymal Stromal Cells as a Therapy for Graft versus Host Disease (Newcastle University)

Tenure-Track Investigator(s) – Musculoskeletal Biology or Diseases of Bone, Cartilage, or Muscle (National Institutes of Health)

Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

Price Gilbert, Jr. Chair – Regenerative Engineering and Medicine (Georgia Institute of Technology)

PhD and Postdoctoral Positions – Stem Cell Genetics (Universiti Putra Malaysia)

Cell Lab Technician – 3D Cell-Culture Matrices (Vienna University of Technology)

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