Mesenchymal Cell News Volume 5.31 | Aug 13 2013

Myeloma Plasma Cells Alter the Bone Marrow Microenvironment by Stimulating the Proliferation of Mesenchymal Stromal Cells
Researchers used mesenchymal stromal cell and osteoblast-related cell surface marker expression and flow cytometry to enumerate mesenchymal stromal cell and osteoblast numbers in bone marrow recovered from myeloma patients at the time of diagnosis. [Haematol] Abstract | Full Article

A Novel Strontium(II)-Modified Calcium Phosphate Bone Cement Stimulates Human-Bone-Marrow-Derived Mesenchymal Stem Cell Proliferation and Osteogenic Differentiation In Vitro
The in vitro effects of novel strontium-modified calcium phosphate bone cements, prepared using two different approaches on human-bone-marrow-derived mesenchymal stem cells, were evaluated. [Acta Biomater] Abstract | Graphical Abstract

Collagen Hydrogels Incorporated with Surface-Aminated Mesoporous Nanobioactive Glass: Improvement of Physicochemical Stability and Mechanical Properties Effective for Hard Tissue Engineering
Mesenchymal stem cells cultivated within a collagen-mesoporous bioactive glass nanoparticle (mBGn) hydrogels were highly viable with enhanced cytoskeletal extensions due to the addition of surface aminated mBGn. [Acta Biomater] Abstract

Cytoplasmic-Targeted Parvalbumin Blocks the Proliferation of Multipotent Mesenchymal Stromal Cells in Prophase
Investigators showed that the adenoviral-parvalbumin-nuclear exclusion signal-Discosoma red fluorescent protein fusion protein decreased serum-induced Ca²⁺ signaling and blocked the proliferation of rat adipose-derived mesenchymal stromal cells in prophase. [Stem Cell Res Ther] Abstract | Full Article

Comparative Proteome Approach Demonstrates that Platelet-Derived Growth Factor C and D Efficiently Induce Proliferation while Maintaining Multipotency of hMSCs
Scientists describe the effects of the platelet-derived growth factor (PDGF) isoforms C and D during in vitro expansion of human mesenchymal stem cells (hMSCs). Their results showed that PDGFs can enhance proliferation of hMSCs without affecting their multipotency. [Exp Cell Res] Abstract

Isolation of Mesenchymal Stem-Like Cells in Meningioma Specimens
Researchers hypothesized that cells similar to bone marrow mesenchymal stem cells exist in meningioma specimens and sought to investigate whether these putative meningioma stroma mesenchymal stem-like cells could be isolated. [Int J Oncol] Abstract

Antioxidants Cause Rapid Expansion of Human Adipose-Derived Mesenchymal Stem Cells via CDK and CDK Inhibitor Regulation
Human adipose-derived mesenchymal stem cells (ADMSCs) cultured in ImF-A medium supplemented with antioxidants and fibroblast growth factor 2 (FGF-2) were compared with ADMSCs cultured with FGF-2 alone or with FGF-2 under 5% pO₂ conditions. [J Biomed Sci] Abstract

Cyclic Tensile Strain Enhances Osteogenesis and Angiogenesis in Human Mesenchymal Stem Cells from Osteoporotic Donors
Researchers demonstrated that human mesenchymal stem cells from aged, osteoporotic donors are capable of enhanced osteogenic differentiation in response to 10% cyclic tensile strain with significant increases in expression of genes associated with enhanced cell proliferation, musculoskeletal development, and angiogenesis. [Tissue Eng Part A] Abstract

rFN/Cad-11-Modified Collagen Type II Biomimetic Interface Promotes the Adhesion and Chondrogenic Differentiation of Mesenchymal Stem Cells
Scientists showed that a designed material was able to stimulate cell proliferation and promote better chondrogenic differentiation of rabbit mesenchymal stem cells in vitro than FN modified surfaces and the negative control. [Tissue Eng Part A] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Grafix^® Demonstrates Overwhelming Efficacy in Landmark Stem Cell Study for the Treatment of Diabetic Foot Ulcers
Osiris Therapeutics, Inc. reported that its multi-center, randomized, controlled clinical trial comparing the safety and effectiveness of Grafix^® to standard of care in patients with chronic diabetic foot ulcers had met the pre-specified stopping rules for overwhelming efficacy as determined by the data monitoring committee during a planned interim analysis. Grafix^® is a human cellular repair matrix that provides a high-quality source of living mesenchymal stem cells. [Osiris Therapeutics, Inc.] Press Release

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

From our sponsor:
Looking for ALDH⁺ cancer stem cells? Watch a video to see how ALDEFLUOR^TM can help.

Visit our events page to see a complete list of events in the mesenchymal cell community.

NEW Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Regeneration of Cartilage and Ligament Tissue (University of California, Los Angeles)

Senior Scientist – Translational Medicine (Celgene Corporation)

PhD Studentship – Mechanobiology of Stem Cells (Queen Mary University of London)

Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

Director of Cell Processing Facility (S L Collins Associates, Inc.)

Recruit Top Talent: Reach more than 50,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.