Mesenchymal Cell News Volume 5.44 | Nov 12 2013

Insulin-Like Growth Factor Binding Proteins 4 and 7 Released by Senescent Cells Promote Premature Senescence in Mesenchymal Stem Cells
Researchers showed that conditioned media of senescent mesenchymal stem cells contain a set of secreted factors that are able to induce a full senescence response in young cells. [Cell Death Dis] Full Article

CD146 Expression on Mesenchymal Stem Cells Is Associated with Their Vascular Smooth Muscle Commitment
CD146^-/Low and CD146^High bone marrow mesenchymal stem cells did not differ in colony-forming unit-fibroblast number, osteogenic, adipogenic and chondrogenic differentiation or in vitro hematopoietic-supportive activity. [J Cell Mol Med] Full Article

The Paracrine Effects of Mesenchymal Stem Cells Stimulate the Regeneration Capacity of Endogenous Stem Cells in the Repair of a Bladder Outlet Obstruction-Induced Overactive Bladder
Scientists report the superior therapeutic efficacy of using mesenchymal stem-cells for the treatment of OAB and a novel therapeutic mechanism that activates endogenous Oct4+ primitive stem-cells. [Stem Cells Dev] Abstract

CC-Chemokine Receptor 5 on Pulmonary Mesenchymal Cells Promotes Experimental Metastasis via the Induction of Erythroid Differentiation Regulator 1
Though commonly associated with bone marrow stroma, Erythroid Differentiation Regulator 1 was differentially expressed in wild type pulmonary mesenchymal cells and murine embryonic fibroblasts. [Mol Cancer Res] Abstract

A Fat Option for the Pig: Hepatocytic Differentiated Mesenchymal Stem Cells for Translational Research
Mesenchymal stem cells (MSC) from porcine adipose tissue and from bone marrow express the typical mesenchymal markers CD44, CD29, CD90 and CD105 but not hematopoietic markers. MSC from both sources displayed differentiation into the osteogenic as well as adipogenic lineage. [ Exp Cell Res] Abstract

Inhibition of Non-Muscle Myosin II Leads to G₀/G₁ Arrest of Wharton’s Jelly-Derived Mesenchymal Stromal Cells
When cultured in the presence of blebbistatin, an inhibitor of non-muscle myosin II adenosine triphosphatase activity, Wharton’s jelly-derived mesenchymal stromal cells exhibited dose-dependent reduction in proliferative potential along with increase in cell size and induction of early senescence. [Cytotherapy] Abstract

Gastritis Promotes an Activated Bone Marrow-Derived Mesenchymal Stem Cell with a Phenotype Reminiscent of a Cancer-Promoting Cell
In culture, bone marrow-derived mesenchymal stem cells (BM-MSCs) are prone to mutation with continued passage but it is unknown whether a similar process occurs in vivo in response to gastritis. Scientists identified the role of chronic gastritis in the transformation of BM-MSCs leading to an activated cancer-promoting phenotype. [ Dig Dis Sci] Abstract

Differentiation of Human Mesenchymal Stem Cells on Plasma-Treated Polyetheretherketone
To evaluate the effect of the plasma-induced polyetheretherketone (PEEK) modifications on stem cell adhesion and differentiation, adipose tissue-derived mesenchymal stem cells (adMSC) were seeded on PEEK specimens. Scientists demonstrated an increased adhesion, proliferation, and osteogenic differentiation of adMSC in contact to plasma-treated PEEK. [J Mater Sci Mater Med] Abstract

Aorta-Derived Mesoangioblasts Can Be Differentiated into Functional Uterine Epithelium, but Not Prostatic Epithelium or Epidermis, by Instructive Mesenchymes
Researchers examined whether aorta-derived mesoangioblasts (ADM) can differentiate into prostatic, uterine, and skin epithelium by recombining ADM with fetal or neonatal mesenchyme from these organs and grafting them under the renal capsule of syngeneic hosts. [Cells Tissues Organs] Abstract

Deciphering Mechanical Regulation of Chondrogenesis in Fibrin-Polyurethane Composite Scaffolds Enriched with Human Mesenchymal Stem Cells; A Dual Computational and Experimental Approach
Researchers used the finite element method, mechanical testing and dynamic in-vitro cell culture experiments on human bone marrow derived mesenchymal stem cells-enriched fibrin-polyurethane composite scaffolds in order to quantitatively decipher the mechanoregulation of chondrogenesis within fibrin-polyurethane composite scaffold constructs. [Tissue Eng Part A] Abstract

Tumor Microenvironment: Bone Marrow-Mesenchymal Stem Cells as Key Players
The authors discuss the role of bone marrow-derived mesenchymal stem cells (BM-MSC) in many steps in tumor progression, focusing on the factors that attract BM-MSC to tumors, BM-MSC differentiation ability, the role of BM-MSC in tumor support or inhibition, the immunomodulation promoted by BM-MSC and metastatic niche formation by these cells. [Biochim Biophys Acta] Abstract

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$100 Million Gift Launches Sanford Stem Cell Clinical Center
Businessman and philanthropist T. Denny Sanford has committed $100 million to the creation of the Sanford Stem Cell Clinical Center at the University of California, San Diego. [University of California, San Diego] Press Release

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Postdoctoral Research Fellows – Stem Cells (Wake Forest Institute for Regenerative Medicine)

Postdoctoral Fellowship – Characterizing the Immunosuppressive Impact of Mesenchymal Stem Cells on T Cells (Food and Drug Administration: Center for Biologics Evaluation and Research)

Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

PhD Student Position – Pro-Tumorigenic Effect of Mesenchymal Stem Cells in Brain Tumors (Ludwig Maximilian University Munich)

Postdoctoral Fellow – Adipose Mesenchymal Stem Cells For Retinal Disease (University of Virginia)

Postdoctoral Research Fellow – Stem Cells (Bioprocessing Technology Institute)

Faculty Positions – Stem Cells and Regenerative Medicine (Baylor College of Medicine)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies Inc.)

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