An Osteopontin-Integrin Interaction Plays a Critical Role in Directing Adipogenesis and Osteogenesis by Mesenchymal Stem Cells Scientists revealed that blockade of osteopontin (OPN) function promoted robust adipogenic differentiation, while inhibiting osteogenic differentiation. Re-expression of OPN restored a normal balance between adipogenesis and osteogenesis in OPN-/- mesenchymal stem cells. [Stem Cells] Full Article Suppression of Orthotopically Implanted Hepatocarcinoma in Mice by Umbilical Cord-Derived Mesenchymal Stem Cells with sTRAIL Gene Expression Driven by AFP Promoter Human umbilical cord-derived mesenchymal stem cells (HUMSCs) were isolated and transduced by lentiviral vectors coding the soluble human tumor necrosis factor-related apoptosis-inducing ligand (sTRAIL) gene driven by alpha-fetoprotein (AFP) promoter to investigate the therapeutic effects of these HUMSC against orthotopically implanted hepatocarcinoma in mice. [Biomaterials] Abstract Application of Stem Cells derived from the Periodontal Ligament or Gingival Tissue Sources for Tendon Tissue Regeneration A co-delivery system based on TGF-ß3-loaded RGD-coupled alginate microspheres was developed for encapsulating periodontal ligament stem cells or gingival mesenchymal stem cells (GMSCs). The capacity of encapsulated dental MSCs to differentiate into tendon tissue was investigated in vitro and in vivo. [Biomaterials] Abstract Intravenous Transplants of Human Adipose-Derived Stem Cell Protect the Brain from Traumatic Brain Injury-Induced Neurodegeneration and Motor and Cognitive Impairments: Cell Graft Biodistribution and Soluble Factors in Young and Aged Rats Investigators examined the beneficial effects of human adipose-derived stem cells in a controlled cortical impact model of mild traumatic brain injury using young and aged F344 rats. [J Neurosci] Abstract Secretome Analysis of Human Mesenchymal Stem Cells Undergoing Chondrogenic Differentiation Researchers followed a double stable isotope labeling by amino acids in cell culture strategy to evaluate the quantitative modulation of the secretome of stem cells isolated from bone marrow during the first steps of their chondrogenic differentiation. [J Proteome Res] Abstract Induction of Myogenic Differentiation of Human Mesenchymal Stem Cells Cultured on Notch Agonist (Jagged-1) Modified Biodegradable Scaffold Surface Biodegradable poly (l-lactide-co-e-caprolactone) scaffold conjugated with Notch agonist-Jagged-1 peptide was prepared to initiate myogenic differentiation of human mesenchymal stem cells. [ACS Appl Mater Interfaces] Abstract A Mouse Bone Marrow Stromal Cell Line with Skeletal Stem Cell Characteristics to Study Osteogenesis In Vitro and In Vivo Mouse bone marrow stromal cells were isolated and osteogenic differentiation was investigated in tissue culture and in vivo. Three out of seven independent cell isolates showed the ability to differentiate into osteocytes, adipocytes, and chondrocytes in vitro. [Stem Cells Dev] Abstract Inhibition of Mesenchymal Stromal Cells by Pre-Activated Lymphocytes and Their Culture Media The interplay between clinical grade mesenchymal stromal cells (MSCs) and pre-activated donor lymphocytes or selected lymphocyte subsets was studied in vitro. A strong inhibition of MSC growth was rapidly induced by the addition of pre-activated lymphocytes but not of resting lymphocytes. [Stem Cell Res Ther] Abstract | Full Article Sera of Overweight People Promote In Vitro Adipocyte Differentiation of Bone Marrow Stromal Cells Researchers observed that in vitro incubation of bone marrow stromal cells with the sera of overweight individuals promotes the adipogenic differentiation of mesenchymal stem cells while partially impairing proper osteogenesis. [Stem Cell Res Ther] Abstract | Full Article Mesenchymal Stem Cells Reciprocally Regulate the M1/M2 Balance in Mouse Bone Marrow-Derived Macrophages Scientists assessed the functional relationship between the macrophage phenotype and mesenchymal stem cells (MSCs). MSCs isolated from bone marrow and bone marrow-derived macrophages underwent differentiation induced by macrophage colony-stimulating factor. [Exp Mol Med] Full Article Autologous Mesenchymal Stromal Cell Infusion as Adjunct Treatment in Patients with Multidrug and Extensively Drug-Resistant Tuberculosis: An Open-Label Phase I Safety Trial Researchers assessed the safety of infusion of autologous mesenchymal stromal cells (MSCs) as an adjunct treatment in patients with tuberculosis. 30 patients with microbiologically confirmed multidrug-resistant or extensively drug-resistant tuberculosis were treated with single-dose autologous bone marrow-derived MSCs, within 4 weeks of the start of antituberculosis-drug treatment in a specialist center in Minsk, Belarus. [Lancet Respir Med] Abstract | Press Release |