Importance of SOX8 for In Vitro Chondrogenic Differentiation of Human Mesenchymal Stromal Cells Scientists demonstrated that SOX8 mRNA levels decrease during in vitro dedifferentiation of human articular chondrocytes and increase during chondrogenic differentiation of mesenchymal stromal cells. [Stem Cells] Abstract Adhesion and Proliferation of Human Mesenchymal Stem Cells from Dental Pulp on Porous Silicon Scaffolds The behavior of human dental pulp stem cells were analyzed on porous silicon substrates presenting pore of various sizes and undergoing different chemical treatments: thermal oxidation, silanization with aminopropyltriethoxysilane, and hydrosilylation with undecenoic acid or semicarbazide. [ACS Appl Mater Interfaces] Abstract Human Mesenchymal Stromal Cells from Adult and Neonatal Sources: A Comparative In Vitro Analysis of Their Immunosuppressive Properties against T Cells Researchers compared mesenchymal stromal cells (MSCs) from bone marrow (BM), umbilical cord blood (UCB) and placenta (PL) in terms of their immunosuppressive properties against lymphoid cell populations enriched for CD3+ T cells. Their results confirm the immunosuppressive potential of BM-MSCs, and demonstrated that MSCs from UCB and, to a lesser extent PL, also have immunosuppressive potential. [Stem Cells Dev] Abstract pVEGF-Loaded Lipopolysaccharide-Amine Nanopolymersomes for Therapeutic Angiogenesis Scientists have demonstrated that their newly developed lipopolysaccharide-amine nanopolymersomes have higher than 95% transfection efficiency when delivering pEGFP into mesenchymal stem cells (MSCs). To explore their clinical potential in therapeutic angiogenesis the scientists studied their toxicity, storage stability, protection ability to genes and efficacy to deliver therapeutic genes of pVEGF in MSCs and zebrafish. [Nanotechnology] Abstract In Vitro and In Vivo Angiogenic Capacity of BM-MSCs/HUVECs and AT-MSCs/HUVECs Cocultures Researchers comparatively evaluated the angiogenic capacity of cocultures using either human bone marrow- or human adipose tissue-derived mesenchymal stem cells (MSCs) (BM- or AT-MSCs) with human umbilical vein endothelial cells (HUVECs) both in vitro and in vivo at early time points. [Biofabrication] Abstract Decellularized Silk Fibroin Scaffold Primed with Adipose Mesenchymal Stromal Cells Improves Wound Healing in Diabetic Mice Researchers demonstrated, for the first time, that electrospun nanofibrous silk fibroin patches, cellularized with human adipose-derived mesenchymal stromal cells or decellularized are effective in the treatment of skin wounds, improving skin regeneration in db/db diabetic mice. [Stem Cell Res Ther] Abstract | Full Article Human Cadaver Multipotent Stromal/Stem Cells Isolated from Arteries Stored in Liquid Nitrogen for 5 Years Cadaveric vascular tissues were established as an alternative source of human cadaver mesenchymal stromal/stem cells. Scientists reported the successful cell isolation from post mortem arterial segments stored in a tissue-banking facility for at least 5 years. [Stem Cell Res Ther] Abstract | Full Article Adult Human Mesenchymal Stem Cells Delivered via Intra-Articular Injection to the Knee Following Partial Medial Meniscectomy: A Randomized, Double-Blind, Controlled Study In a randomized, double-blind, controlled study, the safety of the intra-articular injection of human mesenchymal stem cells into the knee, the ability of mesenchymal stem cells to promote meniscus regeneration following partial meniscectomy, and the effects of mesenchymal stem cells on osteoarthritic changes in the knee were investigated. [J Bone Joint Surg Am] Abstract | Press Release Mesenchymal Stromal (Stem) Cells Suppress Pro-Inflammatory Cytokine Production but Fail to Improve Survival in Experimental Staphylococcal Toxic Shock Syndrome Based on the critical role of host-derived immune mediators in toxic shock syndrome (TSS), scientists hypothesized that mesenchymal stromal (stem) cells could modulate the host-derived proinflammatory response triggered by Staphylococcal enterotoxin B and improve survival in experimental TSS. [BMC Immunol] Full Article Human Bone Marrow-Derived Mesenchymal Stem Cells Display Enhanced Clonogenicity but Impaired Differentiation with Hypoxic Preconditioning Scientists investigated the use of hypoxia as a preconditioning agent and in differentiating cultures to enhance mesenchymal stem cells function. They determined that enhanced clonogenicity was attributable to increased proliferation, increased vascular endothelial growth factor secretion, and increased matrix turnover. [Stem Cells Transl Med] Abstract Novel SCRG1/BST1 Axis Regulates Self-Renewal, Migration, and Osteogenic Differentiation Potential in Mesenchymal Stem Cells Researchers identified the human mesenchymal stem cell (hMSC)-secreted protein SCRG1 and its receptor BST1 as a positive regulator of self-renewal, migration, and osteogenic differentiation. SCRG1 and BST1 gene expression decreased during osteogenic differentiation of hMSCs. [Sci Rep] Full Article |