The Histone Acetylase Activator Pentadecylidenemalonate 1b Rescues Proliferation and Differentiation in Human Cardiac Mesenchymal Cells of Type 2 Diabetic Patients Researchers investigated the diabetes-associated alterations present in cardiac mesenchymal cells obtained from normoglycemic and Type-2 diabetes patients, identifying the histone acetylase activator pentadecylidenemalonate 1b as a potential pharmacological intervention to restore cellular function. [Diabetes] Abstract The Interaction between Mesenchymal Stem Cells and Steroids during Inflammation Scientists applied different concentrations of dexamethasone (Dex) to anti-CD3-activated splenocyte cultured with or without mesenchymal stem cells. As expected, Dex exhibited a classical dose-dependent inhibition of T-cell proliferation. Surprisingly, although MSCs also blocked T-cell proliferation, the presence of Dex unexpectedly showed a dose-dependent reversion of T-cell proliferation. [Cell Death Dis] Full Article TRAIL-Secreting Mesenchymal Stem Cells Promote Apoptosis in Heat-Shock-Treated Liver Cancer Cells and Inhibit Tumor Growth in Nude Mice The therapeutic potential of secretable form of trimeric human tumor necrosis factor-related apoptosis-inducing ligand (stTRAIL)-based gene therapy was evaluated in hepatocellular carcinoma subjected to radiofrequency ablation. Rat bone marrow mesenchymal stem cells were isolated and transduced with a lentiviral vector encoding stTRAIL. [Gene Ther] Abstract Angiopoietin-Like 4 Confers Resistance to Hypoxia/Serum Deprivation-Induced Apoptosis through PI3K/Akt and ERK1/2 Signaling Pathways in Mesenchymal Stem Cells Scientists examined the protective effect of angiopoietin-like 4 on hypoxia/serum deprivation-induced apoptosis of mesenchymal stem cells, as well as the possible mechanisms. [PLoS One] Full Article Primary Cilia Mediate Sonic Hedgehog Signaling to Regulate Neuronal-Like Differentiation of Bone Mesenchymal Stem Cells for Resveratrol Induction In Vitro Researchers showed that primary cilia, harboring patched 1, are present in growth-arrested mesenchymal stem cells (MSCs) and that smoothened and Gli1 are present in cytoplasm of MSCs, which are important components of the Sonic hedgehog signaling pathway. [J Neurosci Res] Abstract Mesenchymal Stem Cell and Gelatin Microparticle Encapsulation in Thermally and Chemically Gelling Injectable Hydrogels for Tissue Engineering Researchers investigated the viability and osteogenic differentiation of mesenchymal stem cells encapsulated with gelatin microparticles in an injectable, chemically and thermally gelling hydrogel system combining poly(N-isopropylacrylamide)-based thermogelling macromers containing pendant epoxy rings with polyamidoamine-based hydrophilic and degradable diamine crosslinking macromers. [J Biomed Mater Res A] Abstract Conditioned Medium of Human Adipose-Derived Mesenchymal Stem Cells Mediates Protection in Neurons following Glutamate Excitotoxicity by Regulating Energy Metabolism and GAP-43 Expression Researchers investigated the neuroprotective effects of human adipose-derived mesenchymal stem cells on cortical neurons using models of glutamate excitotoxicity. [Metab Brain Dis] Full Article Boron Increases the Cell Viability of Mesenchymal Stem Cells after Long-Term Cryopreservation The impacts of various boron concentrations (sodium pentaborate pentahydrate (NaB)) were tested on characterized human tooth germ stem cells (hTGSCs) viability for different time intervals. 20 µg/ml NaB with lower Me2SO concentration was found to display positive effects on hTGSCs during repeated freezing and defrosting cycles, and long-term cryopreservation. [Cryobiology] Abstract Wharton’s Jelly Human Mesenchymal Stem Cell Contact Guidance by Noisy Nanotopographies Scientists studied Wharton’s jelly human mesenchymal stem cells interacting with nanogratings (NGs) having a controlled amount of nanotopographical noise. Their data demonstrated that unperturbed NGs induce cell polarization, alignment and migration along NG lines. [Sci Rep] Full Article |