SIRT6 Regulates Osteogenic Differentiation of Rat Bone Marrow Mesenchymal Stem Cells Partially via Suppressing the Nuclear Factor-Kappa B Signaling Pathway To evaluate the effect of sirtuin 6 (SIRT6) on osteogenesis, rat bone marrow mesenchymal stem cells with enhanced or reduced SIRT6 function were developed. [Stem Cells] Abstract CCR7 Guides Migration of Mesenchymal Stem Cell to Secondary Lymphoid Organs: A Novel Approach to Separate GvHD from GvL Effect Chemokine receptor 7 (CCR7) gene, encoding a receptor that specifically guides migration of immune cells into secondary lymphoid organs, was engineered into a murine mesenchymal stem cell (MSC) line C3H10T1/2 by retrovirus transfection system (MSCs/CCR7). Researchers found that infusion of MSCs/CCR7 potently prolonged the survival of graft-versus-host disease (GvHD) mouse model. [Stem Cells] Abstract Galectin-1 Stimulates Motility of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells by Downregulation of Smad2/3-Dependent Collagen 3/5 and Upregulation of NF-?B-Dependent Fibronectin/Laminin 5 Expression Scientists analyzed 17 extracellular matrix genes in umbilical cord blood-derived mesenchymal stem cells. Galectin-1 decreased the expression of collagen genes COL3A1 and COL5A1 but increased the expression of fibronectin and laminin 5, that were reversed by ß-lactose. [Cell Death Dis] Full Article Bone Marrow-Derived Mesenchymal Stromal Cells Promote Survival and Drug Resistance in Tumor Cells Bone marrow mesenchymal stromal cells but not NIH3T3 or murine skin fibroblasts stimulated the expansion of 4T1 cells in 3D co-cultures, and conditioned medium from these cells increased the viability of 4T1 and LL/2 cells in 2D cultures. [Mol Cancer Ther] Abstract Low Oxygen Tension and Insulin-Like Growth Factor-I (IGF-I) Promote Proliferation and Multipotency of Placental Mesenchymal Stem Cells (PMSCs) from Different Gestations via Distinct Signaling Pathways The impact of varying concentrations of IGF-I and changing oxygen tension on PMSC signaling and multipotency was investigated in PMSCs from early (Preterm) and late (Term) gestation human placentae. [Endocrinology] Abstract Involvement of Angiopoietin-like 4 in Matrix Remodeling during Chondrogenic Differentiation of Mesenchymal Stem Cells Addition of exogenous angiopoietin-like 4 during the course of transforming growth factor beta-induced differentiation reduced the mRNA levels of aggrecan and type II collagen, while it increased those of matrix metallopeptidase (MMP)1 and MMP13. [J Biol Chem] Abstract | Full Article Mesenchymal Stem Cells for Bronchopulmonary Dysplasia: Phase I Dose-Escalation Clinical Trial In a Phase I dose-escalation trial, researchers assessed the safety and feasibility of a single, intratracheal transplantation of human umbilical cord blood-derived mesenchymal stem cells in preterm infants at high risk for bronchopulmonary dysplasia. [J Pediatr] Full Article | Press Release Microparticles from Kidney-Derived Mesenchymal Stem Cells Act as Carriers of Proangiogenic Signals and Contribute to Recovery from Acute Kidney Injury Researchers isolated and characterized microparticles from kidney-derived mesenchymal stem cells. They investigated their in vitro biologic effects on human endothelial cells and in vivo renoprotective effects in acute ischemia-reperfusion renal injury. [PLoS One] Full Article Characterization of Human Mesenchymal Stem Cells from Ewing Sarcoma Patients. Pathogenetic Implications Scientists determined that mesenchymal stem cells obtained specifically from Ewing Sarcoma (EWS) patients (MSC-P) lack the most prevalent gene fusion, EWSR1-FLI1 as well as EWSR1 gene rearrangements. Their study also revealed that MSC-P are more alike to MSC derived from healthy donors than to EWS cells. [PLoS One] Full Article Myocardial Transfection of Hypoxia-Inducible Factor-1alpha and Co-Transplantation of Mesenchymal Stem Cells Enhance Cardiac Repair in Rats with Experimental Myocardial Infarction Researchers investigated the therapeutic effects of myocardial transfection of hypoxia-inducible factor-1alpha (HIF-1alpha) and co-transplantation of mesenchymal stem cells on cardiac repair in myocardial infarction by using myocardial transfection of HIF-1alpha via an adenoviral vector. [Stem Cells Res Ther] Abstract | Full Article Win a $25 Amazon Gift Card! Connexon Creative is evaluating reader interest in a new social media platform. Fill out this quick survey for your chance to win 1 of 4 $25 gift cards! Take survey here |