Mesenchymal Cell News Volume 6.07 | Feb 25 2014

Scaffold-Mediated Lentiviral Transduction for Functional Tissue Engineering of Cartilage
Scientists showed that poly-L-lysine could immobilize lentivirus to poly(e-caprolactone) films and facilitate human mesenchymal stem cell (hMSC) transduction. They then demonstrated that scaffold-mediated gene delivery of transforming growth factor ß3, using a 3D woven poly(e-caprolactone) scaffold, induced robust cartilaginous extracellular matrix formation by hMSCs. [Proc Natl Acad Sci USA] Abstract | Press Release

miR-142-3p Balances Proliferation and Differentiation of Mesenchymal Cells during Lung Development
Investigators determined that miR-142-3p contributes to the proper proliferation of mesenchymal progenitors by controlling the level of WNT signaling. [Development] Abstract

Low-Intensity Pulsed Ultrasound (LIPUS) Influences the Multi-Lineage Differentiation of Mesenchymal Stem and Progenitor Cell Lines through ROCK-Cot/Tpl2-MEK-ERK Signaling Pathway
Researchers applied LIPUS to adipogenic progenitor cell and mesenchymal stem cell lines to analyze how multi-lineage cell differentiation was affected. [J Biol Chem] Abstract | Full Article

Chondrogenically Differentiated Mesenchymal Stromal Cell Pellets Stimulate Endochondral Bone Regeneration in Critical-Sized Bone Defects
Researchers determined if chondrogenically differentiated mesenchymal stromal cells pellets could induce bone regeneration in an orthotopic environment through endochondral ossification. [Eur Cell Mater] Abstract

Cellular Reporter Systems for High-Throughput-Screening of Interactions between Bioactive Matrices and Human Mesenchymal Stromal Cells
Researchers aimed at the identification of extracellular matrix components and candidate morphogens capable of enhancing the expression of hematopoietic stem cell-supportive proteins in human mesenchymal stromal cells, namely Angiopoietin-1 and stromal cell-derived factor 1. [Tissue Eng Part C Methods] Abstract

Comparisons of Rabbit Bone Marrow Mesenchymal Stem Cell Isolation and Culture Methods In Vitro
Isolated bone marrow mesenchymal stem cells were evaluated with respect to primary cell yield, number of CFU-F colonies, proliferative capacity, cell phenotype, and chondrogenic differentiation potential. [PLoS One] Full Article

Umbilical Cord-Derived Mesenchymal Stem Cells Regulate Thymic Epithelial Cell Development and Function in Foxn1^-/- Mice
Scientists used human umbilical cord-derived mesenchymal stem cells to treat forkhead box n1 (Foxn1)^-/- mice, and then analyzed the maturation and distribution of thymic epithelial cells in the Foxn1^-/- thymic rudiment and the thymopoiesis of this newly developed rudiment. [Cell Mol Immunol] Abstract

Adipose Stem Cells Used to Reconstruct 13 Cases with Cranio-Maxillofacial Hard-Tissue Defects
Autologous adipose tissue was harvested from the anterior abdominal wall, and adipose-derived stem cells were cultured, expanded, and then seeded onto resorbable scaffold materials for subsequent reimplantation into hard-tissue defects. [Stem Cells Transl Med] Abstract

Mesenchymal Stem Cells with Modification of Junctional Adhesion Molecule A Induce Hair Formation
Scientists used human junctional adhesion molecule A-modified human mesenchymal stem cells to repair hair follicle abnormalities in BALB/c nu/nu mice. [Stem Cells Transl Med] Abstract

Umbilical Cord Mesenchymal Stem Cells: The New Gold Standard for Mesenchymal Stem Cell Based Therapies?
In this review, the authors aimed to synthesize the differences between umbilical cord-mesenchymal stromal cells (MSCs) and MSCs from other sources (bone marrow, adipose tissue, periodontal ligament, dental pulp,…) concerning their proliferation capacity, proteic and transcriptomic profiles and their secretome involved in their regenerative, homing and immunomodulatory capacities. [Tissue Eng Part B Rev] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Pluristem Receives Key 3D Cell Expansion Patent in Australia
Pluristem Therapeutics, Inc. announced it has been granted a new patent by the Australian Patent Office. Patent #2007228341 covers the method and composition of matter for three-dimensional expansion of placental or adipose (fat) stromal cells, Pluristem’s key technology platform. [Pluristem Therapeutics, Inc.]
Press Release

New Phase IIa Trial in the United States and Phase III Trial in Kazakhstan Study the Use of CardioCell’s Ischemia-Tolerant Mysenchymal Stem Cells Therapy for Treating Acute Myocardial Infarction
CardioCell LLC announced two new clinical trials using its allogeneic stem-cell therapy to treat subjects with acute myocardial infarction, a problem facing more than 1.26 million Americans annually. [CardioCell LLC]
Press Release

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NEW PhD Studentship – Stem Cell Research (University Medical Center Ulm)

Cell Culture Specialist (Tisch MS Research Center of New York)

Associate/Full Professor – Cardiovascular, Pulmonary, Neural Tissue Engineering/Regenerative Medicine (Temple University)

Postdoctoral Fellow – Regenerative Biology (University of California San Francisco)

Research Fellow – Mesenchymal Stem/Stromal Cell Biology (DRK-Blutspendedienst Baden-Württemberg-Hessen gGmbH)

Postdoctoral Researcher Position – Role of Muscle Stem Cells in Tissue Regeneration after Radiation Injury (IRSN [French Nuclear Safety Institute])

Postdoctoral Position – Regenerative Medicine (Centro Cardiologico Monzino IRCCS)

Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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