Regulation of MKL1 via Actin Cytoskeleton Dynamics Drives Adipocyte Differentiation The authors showed that regulation of the transcriptional coactivator MKL1 (megakaryoblastic leukemia 1) by actin cytoskeleton dynamics drives adipocyte differentiation mediated by peroxisome proliferator-activated receptor γ, a master transcriptional regulator of adipogenesis. [Nat Commun] Abstract | Press Release Hypoxia Enhances the Radio-Resistance of Mouse Mesenchymal Stromal Cells Hypoxia was found to increase mesenchymal stromal cell (MSC) proliferation rate and colony size, increase long-term survival post irradiation and improve MSC recovery from radiation-induced cell cycle arrest. [Stem Cells] Abstract ISL1 Overexpression in Human Mesenchymal Stem Cells Promotes Vascularization through Monocyte Chemoattractant Protein-3 Researchers investigated whether forced expression of LIM-homeobox transcription factor islet-1 (ISL1) in human mesenchymal stem cells (hMSCs) influenced the differentiation capacity and angiogenic properties of hMSCs. [Stem Cells] Abstract Age-Related Decreases of Serum-Response Factor Levels in Human Mesenchymal Stem Cells Are Involved in Skeletal Muscle Differentiation and Engraftment Capacity Investigators asked whether human sources of developmentally early-stage mesenchymal stem cells isolated from embryonic stem cells, fetal bone, and term placenta could be cellular sources for skeletal muscle repair. [Stem Cells Dev] Abstract In Vivo Bioluminescent Tracking of Mesenchymal Stem Cells within Large Hydrogel Constructs Luciferase-expressing human mesenchymal stem cells were delivered subcutaneously within agarose and RGD-functionalized alginate hydrogel vehicles to investigate the impact of construct composition and tissue formation on bioluminescent imaging signal. [Tissue Eng Part C Methods] Abstract Nanotopographic Substrates of Poly (Methyl Methacrylate) Do Not Strongly Influence the Osteogenic Phenotype of Mesenchymal Stem Cells In Vitro The authors used thin film substrates of poly(methyl methacrylate) with nanoscale gratings to investigate the influence of nanotopography on the osteogenic phenotype of mesenchymal stem cells, focusing in particular on their ability to produce mineral similar to native bone. [PLoS One] Full Article Evidences for the Involvement of Cell Surface Glycans in Stem Cell Pluripotency and Differentiation Scientists characterized the surface glycans of induced pluripotent stem cells generated from menstrual blood-derived mesenchymal cells (iPS-MBMC) and demonstrated upon spontaneous differentiation, iPS-MBMC present high amounts of terminal β-galactopyranoside residues, pointing to an important role of terminal-linked sialic acids in pluripotency maintenance. [Glycobiology] Abstract Serum-Free Media and the Immunoregulatory Properties of Mesenchymal Stem Cells In Vivo and In Vitro Immunosuppressive activity and the immunomodulatory cytokines produced by mesenchymal stem cells in serum-free media were characterized in vitro. Immunomodulation by serum-free mesenchymal stem cell expansion in monocrotaline-induced pulmonary hypertension was explored in vivo. [Cell Physiol Biochem] Full Article Proteomic Analysis on Effectors Involved in BMP-2-Induced Osteogenic Differentiation of Beagle Bone Marrow Mesenchymal Stem Cells The authors identified the protein regulation profile of recombinant human bone morphogenetic protein-2 (BMP-2)-induced osteogenic differentiation in beagle bone marrow stem cells. [Proteome Sci] Abstract | Full Article Effect and Mechanisms of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells on Type 1 Diabetes in NOD Model Sixty NOD mice were divided into four groups, including normal control group, Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) prevention group (before onset), WJ-MSCs treatment group (after onset), and diabetic control group. [Endocrine] Abstract |