Molecular Imaging for Assessment of Mesenchymal Stem Cells Mediated Breast Cancer Therapy Researchers found that tumors were significantly inhibited by human umbilical cord-derived mesenchymal stem cell administration, and this effect was enhanced by ganciclovir application. [Biomaterials] Abstract Mesenchymal Stem Cells Prevent Hypertrophic Scar Formation via Inflammatory Regulation When Undergoing Apoptosis Scientists locally injected human mesenchymal stem cells (hMSCs) derived from bone marrow to treat hypertrophic scar formation, and explored the underlying mechanisms. They found that hMSC therapy efficiently regulated inflammation and prevented scar formation. [J Invest Dermatol] Abstract Adrenaline Stimulates the Proliferation and Migration of Mesenchymal Stem Cells towards the LPS-Induced Lung Injury Researchers found that adrenaline at 10 µM enhanced proliferation of bone marrow-derived mesenchymal stem cells (BMSCs) through both a- and ß-adrenergic receptors. Adrenaline promoted the migration of BMSCs towards lipopolysaccharide (LPS)-injured lung cells or lung tissue. [J Cell Mol Med] Full Article Matrix Composition and Mechanics Directs Pro-Angiogenic Signaling from Mesenchymal Stem Cells Researchers showed how controlling the mechanical properties and protein composition of the extracellular matrix surrounding mesenchymal stem cells can guide pro-angiogenic signaling. [Tissue Eng Part A] Abstract Downregulation of HDAC1 Is Involved in the Cardiomyocyte Differentiation from Mesenchymal Stem Cells in a Myocardial Microenvironment Investigators determined the acetylation regulatory mechanisms that may be involved in the directed cardiomyocyte differentiation from mesenchymal stem cells. [PLoS One] Full Article Delayed Administration of Bone Marrow Mesenchymal Stem Cell Conditioned Media Significantly Improves Outcome after Retinal Ischemia in Rats Researchers hypothesized that injection of bone marrow stem cell conditioned media after ischemia could rescue ischemic retina, and in this study they characterized the functional and histological outcomes, and mechanisms of this neuroprotection. [Invest Ophthalmol Vis Sci] Abstract Artificial Matrices with High-Sulfated Glycosaminoglycans and Collagen Are Anti-Inflammatory and Pro-Osteogenic for Human Mesenchymal Stromal Cells The influence of artificial extracellular matrices on the interleukin-1ß-induced pro-inflammatory response of human mesenchymal stromal cells was studied. [J Cell Biochem] Abstract Micro-Aggregates Do Not Influence Bone Marrow Stromal Cell Chondrogenesis Researchers investigated the role of the cellular environment (paracrine vs juxtacrine signaling) in the chondrogenic differentiation of bone marrow stromal cells. [J Tissue Eng Regen Med] Abstract Mir-218 Contributes to the Transformation of 5-Aza/GF Induced Umbilical Cord Mesenchymal Stem Cells into Hematopoietic Cells through the MITF Pathway Scientists demonstrated that umbilical cord-derived human mesenchymal stem cells are easily accessible and could be induced into cells with hematopoietic function. [Mol Biol Rep] Abstract Human Mesenchymal Stem Cells Express a Myofibroblastic Phenotype In Vitro: Comparison to Human Cardiac Myofibroblasts Scientists report that, while human bone marrow-derived mesenchymal stem cells retain pluripotency, they adopt a myofibroblastic phenotype in culture and stain positive for the myofibroblast markers a-SMA, vimentin, NMMIIB, ED-A fibronectin, and collagen type 1 at each passage. [Mol Cell Biochem] Abstract |