Cell Isolation Induces Fate Changes of Bone Marrow Mesenchymal Cells Leading to Loss or Alternatively to Acquisition of New Differentiation Potentials Scientists showed that mesenchymal cells, a priori exhibiting a limited differentiation potential, may gain new capacities and become multipotent following single cell isolation. [Stem Cells] Abstract In Vivo Osteogenic Differentiation of Human Turbinate Mesenchymal Stem Cells in an Injectable In Situ-Forming Hydrogel Human turbinate mesenchymal stromal cells (hTMSCs) showed positive expression of mesenchymal stem cell markers and proliferated at a high rate. hTMSCs exhibited osteogenic differentiation in vitro in the presence of osteogenic factors. [Biomaterials] Abstract Interleukin-6 Induces the Lineage Commitment of Bone Marrow-Derived Mesenchymal Multipotent Cells through Down-Regulation of Sox2 by Osteogenic Transcription Factors Researchers aimed to identify mechanisms by which cell-cell interactions between heterogeneous bone marrow-derived mesenchymal stromal cells affect stemness and lineage commitment of multipotent subpopulation. [FASEB J] Abstract Amniotic Mesenchymal Stem Cells Display Neurovascular Tropism and Aid in the Recovery of Injured Peripheral Nerves Researchers determined whether local injection of amniotic membrane-derived mesenchymal stem cells (AMMs) ameliorates peripheral neuropathy. AMMs were transplanted into injured sciatic nerves. AMM injection promoted significant recovery of motor nerve conduction velocity and voltage amplitude compared to human adipose-derived mesenchymal stem cells. [J Cell Mol Med] Abstract Adipose-Derived Regenerative Cells in Patients with Ischemic Cardiomyopathy: The PRECISE Trial Researchers performed the first randomized, placebo-controlled, double-blind trial to examine the safety and feasibility of the transendocardial injections of adipose-derived regenerative cells in no-option patients with ischemic cardiomyopathy. [Am Heart J] Abstract | Press Release Characterization of Constitutive Promoters for piggyBac Transposon-Mediated Stable Transgene Expression in Mesenchymal Stem Cells (MSCs) Researchers used the piggyBac transposon system and conducted a systematic comparison of six commonly-used constitutive promoters for their abilities to drive RFP or firefly luciferase expression in somatic HEK-293 cells and MSC iMEF cells. [PLoS One] Full Article Characteristics of c-Kit+ Progenitor Cells in Explanted Human Hearts Researchers isolated and characterized c-Kit+ progenitor cells from explanted human hearts. Isolated c-Kit+ cells display mesenchymal stem cell features and are thought to differentiate into endothelial cells. [Clin Res Cardiol] Full Article Placental Mesenchymal Stem Cells of Fetal and Maternal Origins Demonstrate Different Therapeutic Potentials Scientists investigated the differences in human placental mesenchymal stem cells of fetal and maternal origins in the aspects of clinical importance. [Stem Cell Res Ther] Abstract | Full Article In Vitro Biosafety Profile Evaluation of Multipotent Mesenchymal Stem Cells Derived from the Bone Marrow of Sarcoma Patients To investigate the possible oncogenic potential of mesenchymal stem cells (MSCs) from osteosarcoma or Ewing sarcoma patients (MSC-SAR) after expansion, scientists focused on a biosafety assessment of MSC-SAR obtained after short- and long-term cultivation compared with MSCs from healthy donors. [J Transl Med] Abstract | Full Article Generation of High-Yield Insulin Producing Cells from Human Bone Marrow Mesenchymal Stem Cells Scientists described a stage specific differentiation protocol for the generation of insulin producing islet-like clusters from human bone marrow mesenchymal stem cells. [Mol Biol Rep] Abstract Down-Regulation of Sox11 Is Required for Efficient Osteogenic Differentiation of Adipose-Derived Stem Cells Scientists performed a microarray-based gene expression profiling of osteogenic differentiation and found that the transcription factor Sox11 is down-regulated during the process. [Mol Cells] Abstract |