Dopamine Mobilizes Mesenchymal Progenitor Cells through D2-Class Receptors and Their PI3K/AKT Pathway Researchers showed that dopamine induced in vitro, mesenchymal progenitor cells migration through D2-class receptors, and their alternative PI3K/Akt pathways. [Stem Cells] Abstract Uremic Toxin p-Cresol Induces Akt-Pathway-Selective Insulin Resistance in Bone Marrow-Derived Mesenchymal Stem Cells Scientists characterized insulin signaling in mesenchymal stem cells (MSCs) and investigated the effect of uremic toxin, p-cresol, on the proangiogenic actions of insulin. In MSCs, insulin induced hypoxia-inducible factor-1α vascular endothelial growth factor, and stromal cell-derived factor-1α expressions via PI3K/Akt-dependent pathway. [Stem Cells] Abstract Loss of Gsα Early in the Osteoblast Lineage Favors Adipogenic Differentiation of Mesenchymal Progenitors and Committed Osteoblast Precursors Researchers showed that targeted ablation of Gsα in early osteoblast precursors, but not in differentiated osteocytes, results in a dramatic increase in bone marrow adipocytes. [J Bone Miner Res] Abstract Direct T Cell-Tumor Interaction Triggers TH1 Phenotype Activation through the Modification of the Mesenchymal Stromal Cells Transcriptional Program Researchers co-cultured human mesenchymal stromal cells (MSCs), tumor infiltrating lymphocytes, and melanoma cells to investigate the role of MSCs in the tumor environment. [Br J Cancer] Full Article Periostin Secreted by Mesenchymal Stem Cells Supports Tendon Formation in an Ectopic Mouse Model Overexpression of periostin alone or in combination with constitutively active BMP receptor type in human mesenchymal stem cells and subsequent implantation into ectopic sites in mice demonstrated a reproducible moderate tenogenic capacity that has not been described before. [Stem Cells Dev] Abstract Characteristics and Properties of Mesenchymal Stem Cells Derived from Micro-Fragmented Adipose Tissue Human adipose derived stem cells derived from microfragmented lipoaspirate tissue have been systematically characterized for growth features, phenotype and multi-potent differentiation potential. They fulfill the definition of mesenchymal stem cells although with a higher neural phenotype profile. [Cell Transplant] Abstract Bone Marrow Stromal Cell Paracrine Factors Direct Osteo/Odontogenic Differentiation of Dental Pulp Cells Scientists compared the biological effects of recombinant human growth differentiation factor five alone and a cocktail of soluble growth factors release from human bone marrow mesenchymal stem cells on the morphology, proliferation and osteo/odontogenic differentiation potential of human dental pulp cells. [Tissue Eng Part A] Abstract Proteomic Analysis of Mesenchymal Stem Cells from Normal and Deep Carious Dental Pulp Researchers defined the molecular features of dental pulp stem cells and carious dental pulp stem cells by comparing the proteomic profiles using two-dimensional fluorescence difference gel electrophoresis in combination with matrix-assisted laser desorption ionization time-of-flight mass spectrometry. [PLoS One] Full Article Changes in PTTG1 by Human TERT Gene Expression Modulate the Self-Renewal of Placenta-Derived Mesenchymal Stem Cells Scientists generated immortalized mesenchymal stem cells (MSCs) derived from MSCs isolated from placenta by human TERT gene transfection with the AMAXA gene delivery system, to compare their characteristics, and to investigate whether increased TERT expression affected the pituitary tumor transforming gene (PTTG1), which is involved in chromosome segregation during mitosis. [Cell Tissue Res] Abstract Bone Marrow-Derived Mesenchymal Stem Cells Migrate to Healthy and Damaged Salivary Glands following Stem Cell Infusion Researchers evaluated stem cell distribution following intravenous and intraglandular injections using a surgical model of salivary gland damage and to analyze the effects of mesenchymal stem cell injections on the recruitment of immune cells. [Int J Oral Sci] Full Article |