Allogeneic Bone Marrow Mesenchymal Stem Cell Transplantation in Patients with UDCA-Resistant Primary Biliary Cirrhosis Researchers evaluated the safety and efficacy of allogeneic bone marrow mesenchymal stromal/stem cell transplantation for patients with ursodeoxycholic acid (UDCA)-resistant primary biliary cirrhosis. [Stem Cells Dev] Abstract Intermittent PTHrP(1-34) Exposure Augments Chondrogenesis and Reduces Hypertrophy of Mesenchymal Stromal Cells Scientists investigated whether intermittent supplementation of parathyroid hormone-related protein (PTHrP), as opposed to constant treatment, can beneficially influence mesenchymal stromal cell chondrogenesis and to explore molecular mechanisms below catabolic and anabolic responses. [Stem Cells Dev] Abstract Different Forms of Tenascin-C with Tenascin-R Regulate Neural Differentiation in Bone Marrow-Derived Human Mesenchymal Stem Cells A combination of tenascinC and tenascinR significantly promoted human bone marrow-derived mesenchymal stem cells differentiation in neurons or oligodendrocytes, induced neurite formation, and inhibited differentiation into astrocytes. [Tissue Eng Part A] Abstract SOCS1 Regulates the Immune Modulatory Properties of Mesenchymal Stem Cells by Inhibiting Nitric Oxide Production Scientists found the suppressor of cytokine signaling 1 (SOCS1) was induced in mesenchymal stem cells (MSCs) treated with inflammatory cytokines. Knockdown of SOCS1 did not bring much difference on the proliferation and differentiation properties of MSCs. [PLoS One] Full Article Human Mesenchymal Cells from Adipose Tissue Deposit Laminin and Promote Regeneration of Injured Spinal Cord in Rats Researchers investigated the regenerative properties of human adipose tissue derived stromal cells (hADSCs) in a rat model of spinal cord compression. Cells were delivered directly into the spinal parenchyma immediately after injury. Human ADSCs promoted functional recovery, tissue preservation, and axonal regeneration. [PLoS One] Full Article Substrate Stiffness and Oxygen Availability as Regulators of Mesenchymal Stem Cell Differentiation within a Mechanically Loaded Bone Chamber Researchers employed a previously developed computational framework to test the hypothesis that substrate stiffness and oxygen availability regulate stem cell differentiation during tissue regeneration within an implanted bone chamber. [Biomech Model Mechanobiol] Abstract Tolerogenic Effect of Mesenchymal Stromal Cells on Gliadin-Specific T Lymphocytes in Celiac Disease Scientists investigated the effects of mesenchymal stromal cells on gliadin-specific T cells, which are known to induce intestinal lesions, in view of a possible use as new therapy. [Cytotherapy] Abstract Enhancement of Adhesion and Promotion of Osteogenic Differentiation of Human Adipose Stem Cells by Poled Electroactive Poly(Vinylidene Fluoride) Non-electroactive α-poly(vinylidene fluoride) (PVDF) and electroactive β-PVDF were used to investigate the substrate polarization and polarity influence on the focal adhesion size and number as well as on human adipose stem cells differentiation. [J Biomed Mater Res A] Abstract Enhancement of Mouse Germ Cell-Associated Genes Expression by Injection of Human Umbilical Cord Mesenchymal Stem Cells into the Testis of Chemical-Induced Azoospermic Mice Researchers investigated whether injection of human umbilical cord mesenchymal stem cells into the interstitial compartment of the testes to promote spermatogenic regeneration efficiently. [Asian J Androl] Full Article |