Selective Inhibition of Inositol Hexakisphosphate Kinases (IP6Ks) Enhances Mesenchymal Stem Cell Engraftment and Improves Therapeutic Efficacy for Myocardial Infarction Researchers investigated the role of IP6Ks for improving mesenchymal stem cells’ functional survival and cardiac protective effect after transplantation into infarcted mice hearts. [Basic Res Cardiol] Abstract Modulation of the Early Inflammatory Microenvironment in the Alkali-Burned Eye by Systemically Administered Interferon-γ-Treated Mesenchymal Stromal Cells Scientists investigated the effects of systemically administered bone marrow-derived mesenchymal stromal cells on the early acute phase of inflammation in the alkali-burned eye. [Stem Cells Dev] Abstract Generation and Characterization of an Immortalized Human Mesenchymal Stromal Cell Line Researchers describe the generation of a telomerase-immortalized non-tumorigenic human bone marrow-derived stromal mesenchymal cell line, and its detailed characterization after long term culturing. [Stem Cells Dev] Abstract Electroacupuncture Promotes the Differentiation of Transplanted Bone Marrow Mesenchymal Stem Cells Pre-Induced with Neurotrophin-3 and Retinoic Acid into Oligodendrocyte-Like Cells in Demyelinated Spinal Cord of Rats Researchers transplanted neurotrophin-3 (NT-3) and retinoic acid pre-induced mesenchymal stem cells into a demyelinated spinal cord induced by ethidium bromide, and investigated whether EA treatment could promote NT-3 secretion in the demyelinated spinal cord. [Cell Transplant] Full Article Positive Selection for Bone Morphogenetic Protein Receptor Type-IB (BMPR-IB) promotes Differentiation and Specification of Human Adipose-Derived Stromal Cells towards an Osteogenic Lineage Human adipose-derived stromal cell subpopulations were prospectively isolated based on expression of BMPR-IB. Unsorted BMPR-IB(+) and BMPR-IB(-) cells were analyzed for their osteogenic capacity through histological staining and gene expression. [Tissue Eng Part A] Abstract Correlating the Effects of BMP to Secreted Soluble Factors from Fibroblasts and Mesenchymal Stem Cells in Regulating Regenerative Processes In Vitro Scientists investigated the effect of soluble factors secreted by fibroblasts and mesenchymal stem cells on the proliferation and migration of cells from the regeneration-competent and -incompetent regions of the mouse digit tip. [Tissue Eng Part A] Abstract Mesenchymal Stem Cells Derived from Human Exfoliated Deciduous Teeth (SHEDs) Induce Immune Modulatory Profile in Monocyte-Derived Dendritic Cells SHEDs are readily accessible, but their immune regulatory properties have not been completely investigated. Researchers evaluated the SHEDs influence on dendritic cells differentiation, maturation, ability to activate T cells and to expand CD4+Foxp3+ T cells. [PLoS One] Full Article Regulating Chondrogenesis of Human Mesenchymal Stromal Cells with a Retinoic Acid Receptor-Beta Inhibitor: Differential Sensitivity of Chondral Versus Osteochondral Development Researchers investigated whether the synthetic retinoic acid receptor-β antagonist LE135 is able to drive in vitro chondrogenesis of human mesenchymal stromal cells or improve differentiation by suppressing hypertrophic chondrocyte development. [Cell Physiol Biochem] Full Article Multi-Lineage Differentiation of Human Mesenchymal Stromal Cells on the Biophysical Microenvironment of Cell-Derived Matrix Under osteogenic conditions, human bone-marrow-derived stromal cells exhibited higher amounts of both mineralized nodule formation and alkaline phosphatase expression than those cultured on plastic or gelatin. [Cell Tissue Res] Abstract Human Placenta Mesenchymal Stem Cells Expressing Exogenous Kringle1-5 Protein by Fiber-Modified Adenovirus Suppress Angiogenesis Scientists report human placenta-derived mesenchymal stem cell-based gene therapy using a fiber-modified adenoviral vector carrying the kringle1-5 gene to maintain long-term survival and effectively suppress angiogenesis both in vitro and in vivo. [Cancer Gene Ther] Abstract Osteogenic Differentiation of Umbilical Cord and Adipose Derived Stem Cells onto Highly Porous 45S5 Bioglass®-Based Scaffolds Researchers evaluated bioactive glass (45S5 Bioglass®) samples as scaffold materials for mesenchymal stem cells. Pore architecture of the scaffolds as well as cell behavior in the 3D environment was evaluated by several methods. [J Biomed Mater Res A] Abstract |