Tenogenic Differentiation of Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Dictated by Properties of Braided Submicron Fibrous Scaffolds Researchers investigated the effect of fiber chemistry and braiding angle on braided submicron fibrous scaffolds (BSMFSs) mechanical properties and in turn, tenogenic differentiation of human induced pluripotent stem cell-derived mesenchymal stem cells seeded on BSMFSs subjected to cyclic tensile stimulation in the absence of tenogenic medium. [Biomaterials] Abstract Bone-Like Apatite Nucleating Nanofibers Induce Differentiation of Human Mesenchymal Stem Cells into Mature Osteoblasts Nanofibers functionalized with osteoinductive collagen I derived Asp-Gly-Glu-Ala peptide sequence provided an advantage in initial adhesion, spreading, and early commitment to osteogenic differentiation for hMSCs. Scientists demonstrated that this early osteogenic commitment, however, does not necessarily guarantee a priority for maturation into functional osteoblasts. [Biomacromolecules] Abstract Bobby Sox Homology Regulates Odontoblast Differentiation of Human Dental Pulp Stem Cells/Progenitors To understand the role of bobby sox homolog (BBX) in odontoblast differentiation, BBX variant 1 and 2 cDNA were cloned and overexpressed in dental pulp stem cells/progenitors. [Cell Commun Signal] Abstract | Full Article Regulation of Mouse Microglia Activation and Effector Functions by Bone Marrow-Derived Mesenchymal Stem Cells Scientists found that mesenchymal stem or stromal cells induce a mixed microglia phenotype defined as Arg-1-high, CD86-high, CD206-high, IL-10-high, PGE2-high, MCP-1/CCL2-high, IL-1β-moderate, NALP-3-low, and TNF-α-low cells. [Stem Cell Dev] Abstract Driving Cartilage Formation in High-Density Human Adipose-Derived Stem Cell Aggregate and Sheet Constructs without Exogenous Growth Factor Delivery Investigators explored the influence of growth factor distribution and release kinetics on cartilage formation within 3D human adipose-derived stem cell constructs incorporated with transforming growth factor-β1 loaded gelatin microspheres. [Tissue Eng Part A] Abstract Skin-Derived Mesenchymal Stem Cells Help Restore Function to Ovaries in a Premature Ovarian Failure Mouse Model To determine the ability of skin-derived mesenchymal stem cells to reactivate injured ovaries, a mouse model with ovaries damaged by busulfan and cyclophosphamide was developed. [PLoS One] Full Article Isolation of a Stable Subpopulation of Mobilized Dental Pulp Stem Cells (MDPSCs) with High Proliferation, Migration, and Regeneration Potential Is Independent of Age Investigators isolated dental pulp stem cells subsets based on their migratory response to granulocyte-colony stimulating factor (MDPSCs) from young and aged donors. The aged MDPSCs were efficiently enriched in stem cells, expressing high levels of trophic factors with high proliferation, migration and anti-apoptotic effects compared to young MDPSCs. [PLoS One] Full Article Peripheral Vein Infusion of Autologous Mesenchymal Stem Cells in Egyptian Hepatitis C Virus Positive Patients with End Stage Liver Disease Investigators assessed the utility of autologous mesenchymal stem cell peripheral vein infusion as a possible therapeutic modality for patients with end-stage liver diseases. [Stem Cell Res Ther] Abstract | Full Article Lipopolysaccharide Differentially Affects the Osteogenic Differentiation of Periodontal Ligament Stem Cells and Bone Marrow Mesenchymal Stem Cells through Toll-Like Receptor 4 Mediated Nuclear Factor KappaB Pathway Researchers comparatively investigated the influence of lipopolysaccharide on the osteogenesis potential of human periodontal ligament stem cells and bone marrow mesenchymal stem cells. [Stem Cell Res Ther] Abstract | Full Article Therapeutic Effect of Bone Marrow Mesenchymal Stem Cells on Laser-Induced Retinal Injury in Mice Researchers investigated the therapeutic potential of bone marrow mesenchymal stem cells by systemic transplantation in a laser-induced retinal injury model. [Int J Mol Sci] Abstract | Download Full Article |