A Novel PPARγ2 Modulator sLZIP Controls the Balance between Adipogenesis and Osteogenesis during Mesenchymal Stem Cell Differentiation The role of sLZIP in regulation of PPARγ2 transcriptional activation was investigated along with sLZIP’s involvement in differentiation of mesenchymal stem cells into adipocytes and osteoblasts. [Cell Death Differ] Abstract Non-Viral Oligonucleotide AntimiR-138 Delivery to Mesenchymal Stem Cell Sheets and the Effect on Osteogenesis Investigators aimed to verify the feasibility of non-viral oligonucleotide delivery for the cell sheets and to confirm the osteogenesis enhancing effect of antimiR-138 on the cell sheets composed of bone marrow mesenchymal stem cells. [Biomaterials] Abstract The IL-6-STAT3 Axis Mediates a Reciprocal Crosstalk between Cancer-Derived Mesenchymal Stem Cells and Neutrophils to Synergistically Prompt Gastric Cancer Progression Researchers investigated the interaction between neutrophils and gastric cancer-derived mesenchymal stem cells (GC-MSCs) and explored the biological role of this interaction. They found that GC-MSCs induced the chemotaxis of neutrophils and protected them from spontaneous apoptosis. [Cell Death Dis] Full Article Carbon Nanotube – Collagen Three-Dimensional Culture of Mesenchymal Stem Cells Promotes Expression of Neural Phenotypes and Secretion of Neurotrophic Factors Scientists focused on carbon nanotubes dispersed within collagen hydrogels to provide three dimensional microenvironmental conditions for mesenchymal stem cells in stimulating biological functions for neural regeneration. [Acta Biomater] Abstract Sequential Third-Party MSC Therapy for Refractory Acute Graft-versus-Host Disease Researchers evaluated the feasibility, safety and efficacy of the administration of four sequential doses of cryopreserved bone marrow-derived mesenchymal stromal cells (MSC) expanded with platelet lysate and obtained from third-party donors as second line treatment for steroid refractory acute graft-versus-host disease in a series of 25 patients. [Biol Blood Marrow Transplant] Abstract Tonsil-Derived Mesenchymal Stem Cells Alleviate Concanavalin A-Induced Acute Liver Injury Intravenous administration of tonsil-derived mesenchymal stem cells (T-MSCs) significantly reduced concanavalin A-induced hepatic toxicity, but not acetaminophen-induced liver injury, affirming the immunoregulatory capacity of T-MSCs. [Exp Cell Res] Abstract Secreted Adiponectin as a Marker to Evaluate In Vitro the Adipogenic Differentiation of Human Mesenchymal Stromal Cells Scientists investigated whether it is possible to assess mesenchymal stromal cell adipogenic differentiation in a more efficient, timely and non-destructive manner, while monitoring in vitro secretion of adiponectin, a hormone specifically secreted by adipose tissue. [Cytotherapy] Abstract Enhanced Proliferation and Differentiation of Oct4- and Sox2-Overexpressing Human Adipose Tissue Mesenchymal Stem Cells Oct4/Sox2-overexpressing adipose tissue mesenchymal stem cells showed higher differentiation abilities for adipocytes or osteoblasts than controls. The markers of adipogenic or osteogenic differentiation were also upregulated by Oct4/Sox2 overexpression. [Exp Mol Med] Full Article An Integrated Study of Natural Hydroxyapatite-Induced Osteogenic Differentiation of Mesenchymal Stem Cells Using Transcriptomics, Proteomics and MicroRNA Analyses Researchers combined transcriptomics, proteomics, and microRNA analyses to elucidate the mechanism of natural hydroxyapatite-induced osteogenic differentiation of mesenchymal stem cells. [Biomed Mater] Abstract Sustained Expression of Coagulation Factor IX by Modified Cord Blood-Derived Mesenchymal Stromal Cells Modification of human CB mesenchymal stromal cells with a lentiviral vector resulted in sustained high Factor IX expression in vitro following differentiation to adipogenic, chondrogenic and osteoblastic cells. [J Gene Med] Abstract |