The Bone Marrow Stromal Compartment in Multiple Myeloma Patients Retains Capability for Osteogenic Differentiation In Vitro: Defining the Stromal Defect in Myeloma Scientists quantified the number of fibroblast colony-forming units and osteoblast colony-forming units in freshly isolated bone marrow from healthy individuals and multiple myeloma patients. [Br J Haematol] Abstract Equine Mesenchymal Stromal Cells and Embryo-Derived Stem Cells Are Immune Privileged In Vitro No immune response is reported following in vivo injection of allogeneic equine mesenchymal stem cells or embryo-derived stem cells into the equine tendon, which may be due to the cells’ immune privileged properties. Researchers investigated these properties to determine their potential for clinical application in other tissues. [Stem Cell Res Ther] Abstract | Full Article Non-Pulsed Sinusoidal Electromagnetic Fields as a Noninvasive Strategy in Bone Repair: The Effect on Human Mesenchymal Stem Cell Osteogenic Differentiation Scientists studied the effect of non-pulsed sinusoidal electromagnetic field radiation tuned at calcium-ion cyclotron frequency of 50 Hz exposure treatment for bone differentiation of human mesenchymal stem cells alone or in synergy with dexamethasone, their canonical chemical differentiation agent. [Tissue Eng Part C Methods] Abstract Discovery and Characterization of miRNA during Cellular Senescence in Bone Marrow-Derived Human Mesenchymal Stem Cells Investigators identified and characterized miRNAs during cellular senescence in mesenchymal stem cells (MSCs). 19 miRNAs showed upregulated expression patterns in senescent MSCs compared with young MSCs, and five miRNAs were downregulated. [Exp Gerontol] Abstract A p38 MAPK-Mediated Alteration of COX-2/PGE2 Regulates Immunomodulatory Properties in Human Mesenchymal Stem Cell Aging Scientists evaluated the effect of replicative senescence on the immunomodulatory ability of human mesenchymal stem cells (hMSCs) in vitro and in vivo. Late-passage hMSCs showed impaired suppressive effect on mitogen-induced mononuclear cell proliferation. [PLoS One] Full Article Enhanced Healing of Rat Calvarial Defects with MSCs Loaded on BMP-2 Releasing Chitosan/Alginate/Hydroxyapatite Scaffolds Investigators evaluated the effect of the chitosan/alginate/hydroxyapatite scaffold as a carrier for recombinant BMP-2 scaffold on the viability and differentiation of bone marrow mesenchymal stem cells (MSCs) by scanning electron microscopy, MTS, ALP assay, alizarin-red staining and qRT-PCR. [PLoS One] Full Article Therapeutic Effects of Mesenchymal Stem Cell-Derived Microvesicles on Pulmonary Arterial Hypertension in Rats Scientists investigated the therapeutic effects of mesenchymal stem cell derived microvesicles on pulmonary artery hypertension in rats. [Acta Pharmacol Sin] Abstract Evaluation of New Bone Formation in Irradiated Areas Using Association of Mesenchymal Stem Cells and Total Fresh Bone Marrow Mixed with Calcium Phosphate Scaffold The authors previously demonstrated the efficacy of biphasic calcium phosphate (BCP) and total fresh bone marrow (TBM) in regenerating irradiated bone defect. They studied whether adding mesenchymal stem cells to BCP + TBM mixture could improve the bone formation in irradiated bone defects. [J Mater Sci Mater Med] Abstract |