Mesenchymal Cell News Volume 6.30 | Aug 12 2014

Mesenchymal Stem Cells Inhibit Lipopolysaccharide-Induced Inflammatory Responses of BV2 Microglial Cells through TSG-6
Researchers investigated the anti-inflammatory effects of mesenchymal stem cells and TNF-alpha stimulated gene/protein 6 (TSG-6) in an in vitro lipopolysaccharide-induced BV2 microglial activation model.
[J Neuroinflammation] Full Article

Viability of Equine Mesenchymal Stem Cells during Transport and Implantation
Efficient transfer of mesenchymal stem cells from the laboratory into tissue requires well-validated transport and implantation techniques. Cell viability in a range of media was determined over 72 hours and after injection through a 19G, 21G or 23G needle. [Stem Cell Res Ther] Abstract | Full Article

Human Umbilical Cord Mesenchymal Stem Cells and Derived Hepatocyte-Like Cells Exhibit Similar Therapeutic Effects on an Acute Liver Failure Mouse Model
Investigators used a D-galactosamine plus lipopolysaccharide-induced acute liver failure mouse model to compare the therapeutic effects of human umbilical cord mesenchymal stem cells before and after induction of differentiation into hepatocyte. [PLoS One] Full Article

CD4⁺CD25 ⁺ Regulatory T Cells Are Not Required for Mesenchymal Stem Cell Function in Fully MHC-Mismatched Mouse Cardiac Transplantation
By using C57BL/6 mouse mesenchymal stem cells (MSCs), scientists discovered that mesenchymal stem cells suppressed CD4⁺ T cell proliferation and prolonged mouse cardiac allograft survival in a dose-dependent and non-major histocompatibility complex (MHC)-restricted manner. [Cell Tissue Res] Abstract

Patient-Tailored Application for Duchene Muscular Dystrophy on Mdx Mice Based Induced Mesenchymal Stem Cells
Researchers examined alternative methods for mesenchymal stem cells (MSC) production and showed that induced pluripotent stem cells may be differentiated into MSCs following exposure to SB431542.
[Exp Mol Pathol] Abstract

Up-Regulation of CXCR4 in Rat Umbilical Mesenchymal Stem Cells Induced by Serum from Rat with Acute Liver Failure Promotes Stem Cells Migration to Injured Liver Tissue
Investigators evaluated rat umbilical mesenchymal stem cells on C-X-C chemokine receptor type 4 (CXCR4) expression and homing to injured liver tissue. [Mol Cell Biochem] Abstract

Proliferation and Differentiation of Human Adipose-Derived Mesenchymal Stem Cells (ASCs) into Osteoblastic Lineage are Passage Dependent
Scientists examined serial subcultivation with expansion on the ability of ASCs to grow and differentiate into osteoblastic lineages. [Inflamm Res] Abstract

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Cedars-Sinai Heart Institute Opens First-of-Its-Kind Research Stem Cell Clinic for Cardiac Patients
Regenerative medicine experts at the Cedars-Sinai Heart Institute have opened a new clinic to evaluate heart and vascular disease patients for participation in stem cell medical studies.
[Cedars-Sinai Medical Center (Newswire LLC)] Press Release

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Postdoctoral Position – Biomaterials/Cartilage Regeneration (Peking University)

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