Mesenchymal Cell News Volume 6.33 | Sept 2 2014

Influence of Insulin-Like Growth Factor I Overexpression via Recombinant Adeno-Associated Vector Gene Transfer upon the Biological Activities and Differentiation Potential of Human Bone Marrow-Derived Mesenchymal Stem Cells
Investigators examined the potential benefits of sustained overexpression of the mitogenic and pro-anabolic insulin-like growth factor I via gene transfer upon the biological activities of human mesenchymal stem cells. [Stem Cell Res Ther] Abstract | Full Article

Novel Daidzein Analogs Enhance Osteogenic Activity of Bone Marrow-Derived Mesenchymal Stem Cells and Adipose-Derived Stromal/Stem Cells through Estrogen Receptor Dependent and Independent Mechanisms
Scientists explored the effects of daidzein analogs on the osteogenic differentiation efficiency of human bone marrow-derived mesenchymal stem cells and adipose-derived stromal/stem cells. [Stem Cell Res Ther]
Abstract | Full Article

TNFalpha and IL-1beta Influence the Differentiation and Migration of Murine MSCs Independently of the NF-kappaB Pathway
The authors determined if pro-inflammatory cytokines altered the differentiation and migration capacity of murine mesenchymal stem cells (MSCs) from different mouse strains and if this was mediated by NF-kappaB.
[Stem Cell Res Ther] Abstract | Full Article

Umbilical Cord Mesenchymal Stem Cells Inhibit the Differentiation of Circulating T Follicular Helper Cells in Patients with Primary Sjögren’s Syndrome through the Secretion of Indoleamine 2,3-Dioxygenase
Researchers investigated the effect of umbilical cord mesenchymal stem cells on circulating T follicular helper cells in primary Sjögren’s Syndrome patients. [Rheumatology] Abstract

Systemic Infusion of Mesenchymal Stem Cells Improves Cell-Based Bone Regeneration via Upregulation of Regulatory T Cells
Investigators showed that bone marrow mesenchymal stem cells (BMMSCs) possessed an immunomodulatory function in vitro and that systemic BMMSC infusion significantly improved cell-based repair of critical-sized calvarial defects in a murine model. [Tissue Eng Part A] Abstract

Mesenchymal Stem/Progenitor Cell Isolation from Tooth Extraction Sockets
Researchers identified and characterized a population of stem/progenitor cells in granulation tissue obtained from the dental socket that exhibited several characteristics similar to those of bone marrow-derived mesenchymal stem/progenitor cells. [J Dent Res] Abstract

Reconstruction of Beagle Hemi-Mandibular Defects with Allogenic Mandibular Scaffolds and Autologous Mesenchymal Stem Cells
Scientists tested whether treatment of graft with mesenchymal stem cells can increase the integration of massive allografts (hemi-mandible) in a large animal model. [PLoS One] Full Article

Improved Quality of Cartilage Repair by Bone Marrow Mesenchymal Stem Cells for Treatment of an Osteochondral Defect in a Cynomolgus Macaque Model
Researchers investigated whether incorporation of mesenchymal stem cells into the collagen scaffold improves integration and repair of cartilage defects in a cynomolgus macaque model. [Acta Orthop] Full Article

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Treatment with Aastrom’s Ixmyelocel-T Shown to Reduce Incidence of Major Adverse Cardiovascular Events in Patients with Ischemic Dilated Cardiomyopathy
Aastrom Biosciences, Inc. announced that results from the company’s Phase IIa clinical studies of ixmyelocel-T for the treatment of advanced heart failure due to ischemic dilated cardiomyopathy. [Aastrom Biosciences, Inc.] Press Release

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NEW Postdoctoral Position – Intestinal Immunology (BSRC Fleming)

Mesenchymal Stromal/Stem Cell Scientist (UHN Arthritis Program)

Researcher – Phenotypic and Functional Characterization of Adult Stem/Stromal Cells from Bone Marrow and Adipose Tissue (Etablissement Français du Sang Pyrénées-Méditerranée)

PhD Position – Tissue Engineering and Stem Cell Biology (Dublin City University)

Postdoctoral Fellow – Intestinal Immunology (BSRC Fleming)

Postdoctoral Position – Biomaterials/Cartilage Regeneration (Peking University)

Postdoctoral Fellowship – Developing Applications of Mesenchymal Stromal/Stem Cells in Hematopoietic Cell Transplantation (The Research Institute at Nationwide Children’s Hospital)

Scientist – Mesenchymal Stem and Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

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