P2X7-Induced Zeiosis Promotes Osteogenic Differentiation and Mineralization of Postmenopausal Bone Marrow-Derived Mesenchymal Stem Cells Scientists investigated the role of the P2X7 receptor on osteogenic differentiation and mineralization of bone marrow mesenchymal stem cell cultures from postmenopausal women. [FASEB J] Abstract Influence of Insulin-Like Growth Factor I Overexpression via Recombinant Adeno-Associated Vector Gene Transfer upon the Biological Activities and Differentiation Potential of Human Bone Marrow-Derived Mesenchymal Stem Cells Investigators examined the potential benefits of sustained overexpression of the mitogenic and pro-anabolic insulin-like growth factor I via gene transfer upon the biological activities of human mesenchymal stem cells. [Stem Cell Res Ther] Abstract | Full Article Novel Daidzein Analogs Enhance Osteogenic Activity of Bone Marrow-Derived Mesenchymal Stem Cells and Adipose-Derived Stromal/Stem Cells through Estrogen Receptor Dependent and Independent Mechanisms Scientists explored the effects of daidzein analogs on the osteogenic differentiation efficiency of human bone marrow-derived mesenchymal stem cells and adipose-derived stromal/stem cells. [Stem Cell Res Ther] Abstract | Full Article TNFalpha and IL-1beta Influence the Differentiation and Migration of Murine MSCs Independently of the NF-kappaB Pathway The authors determined if pro-inflammatory cytokines altered the differentiation and migration capacity of murine mesenchymal stem cells (MSCs) from different mouse strains and if this was mediated by NF-kappaB. [Stem Cell Res Ther] Abstract | Full Article Umbilical Cord Mesenchymal Stem Cells Inhibit the Differentiation of Circulating T Follicular Helper Cells in Patients with Primary Sjögren’s Syndrome through the Secretion of Indoleamine 2,3-Dioxygenase Researchers investigated the effect of umbilical cord mesenchymal stem cells on circulating T follicular helper cells in primary Sjögren’s Syndrome patients. [Rheumatology] Abstract Systemic Infusion of Mesenchymal Stem Cells Improves Cell-Based Bone Regeneration via Upregulation of Regulatory T Cells Investigators showed that bone marrow mesenchymal stem cells (BMMSCs) possessed an immunomodulatory function in vitro and that systemic BMMSC infusion significantly improved cell-based repair of critical-sized calvarial defects in a murine model. [Tissue Eng Part A] Abstract Mesenchymal Stem/Progenitor Cell Isolation from Tooth Extraction Sockets Researchers identified and characterized a population of stem/progenitor cells in granulation tissue obtained from the dental socket that exhibited several characteristics similar to those of bone marrow-derived mesenchymal stem/progenitor cells. [J Dent Res] Abstract Reconstruction of Beagle Hemi-Mandibular Defects with Allogenic Mandibular Scaffolds and Autologous Mesenchymal Stem Cells Scientists tested whether treatment of graft with mesenchymal stem cells can increase the integration of massive allografts (hemi-mandible) in a large animal model. [PLoS One] Full Article Improved Quality of Cartilage Repair by Bone Marrow Mesenchymal Stem Cells for Treatment of an Osteochondral Defect in a Cynomolgus Macaque Model Researchers investigated whether incorporation of mesenchymal stem cells into the collagen scaffold improves integration and repair of cartilage defects in a cynomolgus macaque model. [Acta Orthop] Full Article |