Long Term Evaluation of Mesenchymal Stem Cell Therapy in a Feline Model of Chronic Allergic Asthma Researchers documented the effects of allogeneic, adipose-derived mesenchymal stem cells (MSCs) on airway inflammation, airway hyperresponsiveness, and remodeling over time and investigated mechanisms by which MSCs alter local and systemic immunologic responses in chronic experimental feline allergic asthma. [Clin Exp Allergy] Abstract Paracrine Factors Secreted by Umbilical Cord Derived Mesenchymal Stem Cells Induce Angiogenesis In Vitro by a VEGF-independent Pathway Investigators evaluated the presence of well-known pro-angiogenic factors in the conditioned media (CM) derived from umbilical cord derived-mesenchymal stem cells by ELISA. While VEGF, a well-known angiogenic factor was not detected in the CM, gene expression was nevertheless detected in these cells. [Stem Cells Dev] Abstract Identification of Small Activating RNAs that Enhance Endogenous OCT4 Expression in Human Mesenchymal Stem Cells By screening of dsRNAs targeting OCT4 promoter, the authors identified a small activating RNA (saRNA) that activated OCT4 expression in several types of human mesenchymal stem cells. They found that saRNA-induced OCT4 activation can be further enhanced by a histone deacetylase inhibitor, valproic acid. [Stem Cells Dev] Abstract Immunogenicity of Allogeneic Mesenchymal Stem Cells Transplanted via Different Routes in Diabetic Rats Investigators evaluated the immunogenicity of allogeneic mesenchymal stem cells (MSCs) in vivo by transplanting MSCs into normal and diabetic rats via the tail vein or pancreas and found that MSCs exhibited low immunogenicity in normal recipients and even exerted some immunosuppressive effects in diabetic rats during the initial phase. [Cell Mol Immunol] Abstract Placental Mesenchymal Stem Cells of Fetal Origin Deposit Epigenetic Alterations during Long-Term Culture under Serum-Free Condition Fetal placental mesenchymal stem cells (fPMSCs) have shown promising cell therapy potentials. However, their genetic and epigenetic stability during in vitro propagation has not been well studied. Researchers thus interrogated the methylation alterations and tumorigenicity of fPMSCs after in vitro expansion using serum-free medium. [Expert Opin Biol Ther] Abstract Targeting of ALK2, a Receptor for Bone Morphogenetic Proteins, Using the Cre/Lox System to Enhance Osseous Regeneration by Adipose-Derived Stem Cells Investigators demonstrate that ALK2 may serve as a novel target to improve in vitro adipose-derived stem cell osteogenic differentiation and enhance in vivo bone regeneration and calvarial healing. [Stem Cells Transl Med] Abstract Syngeneic Cardiac and Bone Marrow Stromal Cells Display Tissue-Specific MicroRNA Signatures and MicroRNA Subsets Restricted to Diverse Differentiation Processes MicroRNA expression profiling experiments were performed on syngeneic cardiac and bone marrow mesenchymal stromal cells cultured in standard growth medium and then in vitro exposed to adipogenic, osteogenic, cardiomyogenic and endothelial differentiation media. [PLoS One] Full Article Graphene Supports In Vitro Proliferation and Osteogenic Differentiation of Goat Adult Mesenchymal Stem Cells: Potential for Bone Tissue Engineering Investigators evaluated graphene, a biocompatible inert nanomaterial, for its effect on in vitro growth and differentiation of goat adult mesenchymal stem cells. Cell proliferation and differentiation are compared between polystyrene-coated tissue culture plates and graphene-coated plates. [J Appl Toxicol] Abstract Isolation and Characterization of Human Mesenchymal Stem Cells from Gingival Connective Tissue The authors aimed to isolate and characterize gingival connective tissue-derived mesenchymal stem cells (GMSCs). They also aimed to present a modified isolation method for the GMSCs. [J Periodontal Res] Abstract The Functional Study of Human Umbilical Cord Mesenchymal Stem Cells Harboring Angiotensin-Converting Enzyme 2 in Rat Acute Lung Ischemia-Reperfusion Injury Model The authors aimed to find a more effective therapeutic approach to treat acute lung ischemia-reperfusion injury (ALIRI). They evaluated the combinational effects of human umbilical cord mesenchymal stem cells and angiotensin-converting enzyme 2 in the rat ALIRI model. [Cell Biochem Funct] Abstract |