Differential Efficacy of Human Mesenchymal Stem Cells Based on Source of Origin The authors provided insight into the optimum source of mesenchymal stem cells (MSCs) and identified in vitro assays that predict in vivo efficacy. They derived MSCs from four umbilical cords, four healthy bone marrows (BMs), and four lupus BMs. [J Immunol] Abstract Role of Gamma-Secretase in Human Umbilical-Cord Derived Mesenchymal Stem Cell Mediated Suppression of NK Cell Cytotoxicity Scientists studied the interaction of umbilical cord derived (UC)-mesenchymal stem cells (MSCs) with unstimulated allogeneic natural killer (NK) cells. UC-MSCs could potently suppress NK cell cytotoxicity in overnight cultures via the soluble factors. [Cell Commun Signal] Abstract | Full Article Promoting the Recovery of Injured Liver with PHBVHHx Scaffolds Loaded with Umbilical Cord-Derived Mesenchymal Stem Cells Poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-3-hydroxyhexanoate) (PHBVHHx) scaffolds loaded with mesenchymal stem cells that were isolated from umbilical cord were transplanted into liver-injured mice. Liver morphology improved after 30 days of transplantation and looked similar to normal liver. [Tissue Eng Part A] Abstract Corticosterone Mediates the Inhibitory Effect of Restraint Stress on the Migration of Mesenchymal Stem Cell to Carbon Tetrachloride-Induced Fibrotic Liver by Down-Regulating CXCR4/7 Expression Investigators employed a carbon tetrachloride-induced mouse liver fibrosis model to investigate whether constraint stress affects the migration of MSCs to fibrotic liver. [Stem Cells Dev] Abstract Variations of Chromosomes 2 and 3 Gene Expression Profiles among Pulmonary Telocytes, Pneumocytes, Airway Cells, Mesenchymal Stem Cells and Lymphocytes Researchers compared gene expression profiles of pulmonary telocytes, mesenchymal stem cells, fibroblasts, alveolar type II cells, airway basal cells, proximal airway cells, CD8+ T cells from bronchial lymph nodes, and CD8+ T cells from lungs. [J Cell Mol Med] Full Article MSC Therapy Attenuates Obliterative Bronchiolitis after Murine Bone Marrow Transplant Administration of mesenchymal stromal cells (MSCs) was evaluated for the ability to ameliorate obliterative bronchiolitis in mice using an established allogeneic bone marrow transplant model. [PLoS One] Full Article Effects of Different Mesenchymal Stromal Cell Sources and Delivery Routes in Experimental Emphysema Researchers assessed whether the effects of mesenchymal stromal cells (MSC) on lung inflammation and remodeling in experimental emphysema would differ according to MSC source and administration route. [Respir Res] Full Article Roles of FGF-2 and TGF-Beta/FGF-2 on Differentiation of Human Mesenchymal Stem Cells towards Nucleus Pulposus-Like Phenotype Mesenchymal stem cells were cultured in conditioned medium containing fibroblast growth factor (FGF)-2 or transforming growth factor (TGF)-beta/FGF-2, and compared with basal or TGF-beta medium. The groups with FGF-2 showed the increase of cell proliferation. [Growth Factors] Abstract Combining Xanthan and Chitosan Membranes to Multipotent Mesenchymal Stromal Cells as Bioactive Dressings for Dermo-Epidermal Wounds Investigators assessed the applicability of bioactive dressings associating dense and porous chitosan-xanthan membranes to multipotent mesenchymal stromal cells for the treatment of skin wounds. [J Biomater Appl] Abstract The Temporal Expression of Estrogen Receptor Alpha-36 and Runx2 in Human Bone Marrow Derived Mesenchymal Stromal Cells during Osteogenesis Scientists investigated the temporal expression of estrogen receptor-α36 and ascertain its functional relevance during osteogenesis in human bone marrow derived mesenchymal stromal cells. [Biochem Biophys Res Commun] Abstract |