Mesenchymal Cell News Volume 6.39 | Oct 14 2014

Non-Invasive Characterization of the Adipogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stromal Cells by HS-SPME/GC-MS
Using optimized procedures, researchers discovered that seven fatty acid methyl esters were only detected in adipogenic differentiated mesenchymal stromal cells and not in the mesenchymal stromal cells before differentiation. [Sci Rep] Full Article

Intermittent PTHrP(1-34) Exposure Augments Chondrogenesis and Reduces Hypertrophy of Mesenchymal Stromal Cells
Scientists evaluated whether intermittent supplementation of parathyroid hormone-related protein (PTHrP), as opposed to constant treatment, can beneficially influence mesenchymal stromal cells chondrogenesis and explored molecular mechanisms below catabolic and anabolic responses. [Stem Cells Dev] Full Article

Paracrine-Mediated Neuroprotection and Neuritogenesis of Axotomized Retinal Ganglion Cells by Human Dental Pulp Stem Cells: Comparison with Human Bone Marrow and Adipose-Derived Mesenchymal Stem Cells
Researchers investigated and compared the neurotrophic activity of human dental pulp stem cells, human bone marrow-derived mesenchymal stem cells and human adipose-derived stem cells on axotomized adult rat retinal ganglion cells (RGC) in vitro in order to evaluate their therapeutic potential for neurodegenerative conditions of RGC. [PLoS One] Full Article

Testing Stem Cell Therapy in a Rat Model of Inflammatory Bowel Disease: Role of Bone Marrow Stem Cells and Stem Cell Factor in Mucosal Regeneration
Scientists explored a role of bone marrow mesenchymal stromal cells and soluble stem cell factor in gastrointestinal mucosa regeneration in a rat model of inflammatory bowel diseases. [PLoS One] Full Article

Effects of Different Mesenchymal Stromal Cell Sources and Delivery Routes in Experimental Emphysema
Investigators assessed whether the effects of mesenchymal stromal cells (MSC) on lung inflammation and remodeling in experimental emphysema would differ according to MSC source and administration route.
[Respir Res] Full Article

Comparison of Therapeutic Characteristics of Islet Cell Transplantation Simultaneous with Pancreatic Mesenchymal Stem Cell Transplantation in Rats with Type 1 Diabetes Mellitus
Researchers investigated the effect of pancreatic mesenchymal stem cell transplantation simultaneous with islet cell transplantation on islet liveliness and thus on the treatment of diabetes in type 1 diabetic rats.
[Stem Cell Rev] Abstract

Curcumin-Induced Heme Oxygenase-1 Expression Prevents H₂O₂-Induced Cell Death in Wild Type and Heme Oxygenase-2 Knockout Adipose-Derived Mesenchymal Stem Cells
In order to analyze potential modulatory effects of the heme oxygenase (HO)-system on adipose-derived mesenchymal stem cell (ASC) survival, wildtype and HO-2 knockout ASCs were pre-treated with HO-activity modulators, or downstream effector molecules biliverdin, bilirubin, and CO before co-exposure of ASCs to a toxic dose of H₂O₂. [Int J Mol Sci] Abstract | Download Full Article

Myocardin and Pdx-1 Synergistically Induce hMSCs to Differentiate into Insulin Secreting Cells
Researchers investigated a new method to induce the differentiation of human mesenchymal stem cells (hMSCs) into insulin secretion cells and explored its molecular mechanisms. They investigated in vitro differentiation of hMSCs by overexpression of myocardin and pdx-1. [Biochem Biophys Res Commun] Abstract

A Review of Therapeutic Effects of Mesenchymal Stem Cell Secretions and Induction of Secretory Modification by Different Culture Methods
This review summarizes the up- and down-regulation of mesenchymal stem cell anti-inflammatory, immune modulating, anti-tumor, and regenerative secretions resulting from different stimuli. [J Transl Med]
Abstract | Full Article

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Henry Ford Celebrates First Double-Cord Stem Cell Transplant
Doctors at Henry Ford Hospital are celebrating the success of the system’s first double-cord stem cell transplant, a promising treatment for African Americans and other minorities affected by disparities in life-saving transplant options. [Henry Ford Hospital] Press Release

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Research Associate Position – Skeletal Research Center (Case Western Reserve University)

PhD Studentship – Biophysics and Mechanics of Stem Cells (Queen Mary University of London)

Postdoctoral Position – Epigenetics in Aging, Osteoporosis and Stem Cells (Aachen University Medical School)

Postdoctoral Fellow – Chondrocyte Differentiation and Its Role in Osteoarthritis (NYU Langone Medical Center)

Faculty Positions – Stem Cells and Regenerative Medicine (Baylor College of Medicine)

Postdoctoral Fellowship – Epigenetic Regulation of Cell Fate and Metabolism (University Medical Center Freiburg)

Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

Mesenchymal Stromal/Stem Cell Scientist (UHN Arthritis Program)

Scientist – Mesenchymal Stem and Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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