Aging Disrupts Cell Subpopulation Dynamics and Diminishes the Function of Mesenchymal Stem Cells Scientists utilized single cell transcriptional analysis to determine the effect of aging on mesenchymal stem cell (MSC) population dynamics. They identified an age-related depletion of a subpopulation of MSCs characterized by a pro-vascular transcriptional profile. [Sci Rep] Full Article Safety and Neurological Assessments after Autologous Transplantation of Bone Marrow Mesenchymal Stem Cells in Subjects with Chronic Spinal Cord Injury Researchers evaluated the feasibility, safety and potential efficacy of autologous transplantation of mesenchymal stem cells in subjects with chronic complete spinal cord injury (SCI). They conducted a Phase I, non-controlled study in 14 subjects of both genders aging between 18 to 65 years, with chronic traumatic SCI. [Stem Cell Res Ther] Abstract | Full Article MicroRNA-378 Promotes Mesenchymal Stem Cells Survival and Vascularization under Hypoxic-Ischemic Condition In Vitro Scientists investigated the influence of microRNA-378 transfection on mesenchymal stem cells survival and vascularization under hypoxic-ischemic condition in vitro. [Stem Cell Res Ther] Abstract | Full Article Anti-Inflammatory/Tissue Repair Macrophages Enhance the Cartilage-Forming Capacity of Human Bone Marrow-Derived Mesenchymal Stromal Cells Researchers investigated whether macrophages with, respectively, pro-inflammatory and tissue-remodeling traits differentially modulate chondrogenesis of bone marrow derived-mesenchymal stem/stromal cells. [J Cell Physiol] Abstract Bone Marrow Regeneration Promoted by Biophysically Sorted Osteoprogenitors from Mesenchymal Stromal Cells By leveraging biophysical traits of mesenchymal stromal cell (MSC) subpopulations and label-free microfluidic cell sorting, scientists hypothesized and experimentally verified that MSCs of large diameter within expanded MSC cultures were osteoprogenitors that exhibited significantly greater efficacy over other MSC subpopulations in bone marrow repair. [Stem Cells Transl Med] Abstract Hypoxia-Controlled EphA3 Marks a Human Endometrium-Derived Multipotent Mesenchymal Stromal Cell that Supports Vascular Growth Scientists discovered the hypoxia inducible factor-1α-controlled expression of EphA3, an Eph family member with critical functions during human tumor progression, in the vascularized tissue of regenerating human endometrium and on isolated human endometrial multipotent mesenchymal stromal cells, but not in other highly vascularized human organs. [PLoS One] Full Article Differentiated Mesenchymal Stem Cells Ameliorate Cardiovascular Complications in Diabetic Rats Bone marrow mesenchymal stem cells (MSCs) differentiated to insulin-secreting β-cells were used to treat STZ-induced diabetic rats. The post-homing effects of the differentiated MSCs were endogenous with definite reversal of diabetic parameters. [Cell Tissue Res] Abstract Functionally Deficient Mesenchymal Stem Cells Reside in the Bone Marrow Niche with M2-Macrophages and Amyloid-β Protein Adjacent to Loose Total Joint Implants Researchers sought to demonstrate whether there is a difference in the local mesenchymal stem cell niche obtained from patients undergoing their first total joint replacement surgery versus those patients undergoing a revision surgery for an failing total joint implant. [J Orthop Res] Abstract Chondroitin Sulfate Microparticles Modulate Transforming Growth Factor-β1-Induced Chondrogenesis of Human Mesenchymal Stem Cell Spheroids Scientists examined the effects of incorporating chondroitin sulfate methacrylate microparticles within small mesenchymal stem cells spheroids cultured in the presence of transforming growth factor-β1 on chondrogenesis. [Cells Tissues Organs] Full Article |