Mesenchymal Cell News Volume 6.47 | Dec 16 2014

Hypoxia-Cultured Human Adipose-Derived Mesenchymal Stem Cells Are Non-Oncogenic and Have Enhanced Viability, Motility, and Tropism to Brain Cancer
Researchers investigated the effects hypoxic culture conditions have on primary intraoperatively derived human adipose-derived mesenchymal stem cells (hAMSCs). hAMSCs cultured under hypoxia remained multipotent, capable of differentiation into osteogenic, chondrogenic, and adipogenic lineages. [Cell Death Dis] Full Article

CXCR4 Overexpression in Mesenchymal Stem Cells Facilitates Treatment of Acute Lung Injury in Rats
The influence of CXCR4 expression on migration, proliferation, differentiation, and paracrine effects of mesenchymal stem cells (MSCs) was examined in vitro. The in vivo properties of CXCR4-MSCs were also investigated in a model of acute lung injury in rats induced by lipopolysaccharide. [J Biol Chem]
Abstract | Full Article

Disturbed Angiogenic Activity of Adipose-Derived Stromal Cells Obtained from Patients with Coronary Artery Disease and Diabetes Mellitus Type 2
Scientists analyzed if adipose-derived stromal cells properties are attenuated in patients with chronic diseases such as coronary artery disease and diabetes mellitus type 2. [J Transl Med] Abstract | Full Article

Autologous Bone Marrow Derived Mesenchymal Stromal Cell Therapy in Combination with Everolimus to Preserve Renal Structure and Function in Renal Transplant Recipients
Scientists tested the hypothesis that mesenchymal stromal cells treatment, in combination with the mammalian target of rapamycin inhibitor everolimus, facilitates tacrolimus withdrawal, reduces fibrosis and decreases the incidence of opportunistic infections compared to standard tacrolimus dose. [J Transl Med]
Abstract | Full Article

In Vitro Assessment of Nanosilver-Functionalized PMMA Bone Cement on Primary Human Mesenchymal Stem Cells and Osteoblasts
Polymethylmethacrylate (PMMA) bone cement functionalized with silver nanoparticles and/or gentamicin were tested regarding their biocompatibility with bone forming cells. Influences on viability, cell number and differentiation of primary human mesenchymal stem cells (MSCs) and MSCs cultured in osteogenic differentiation media caused by the implant materials were studied. [PLoS One] Full Article

PDGF-AA Promotes Osteogenic Differentiation and Migration of Mesenchymal Stem Cell by Down-Regulating PDGFRα and Derepressing BMP-Smad1/5/8 Signaling
Researchers show that platelet-derived growth factor (PDGF)-AA, but not -AB or -BB, could activate the BMP-Smad1/5/8 pathway in mesenchymal stem cells, which requires BMPRIA as well as PDGFRα. [PLoS One]
Full Article

Multiscale Modeling of Trabecular Bone Marrow: Understanding the Micromechanical Environment of Mesenchymal Stem Cells during Osteoporosis
Scientists developed a multiscale model that discretely represents the cellular constituents of trabecular bone marrow and applied this model to characterize mechanical stimulation of mesenchymal stem cells in vivo. [J Biomech Eng] Abstract

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BrainStorm Receives $1,100,000 for Its 8^th Annual Non-Dilutive Grant from Israel’s Chief Scientist Office
BrainStorm Cell Therapeutics Inc. announced that wholly-owned subsidiary Brainstorm Cell Therapeutics Ltd. was awarded a grant of approximately $1.1 million from Israel’s Office of the Chief Scientist. [BrainStorm Cell Therapeutics Inc.] Press Release

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Postdoctoral Position – Epigenetic Regulation of Cell Fate and Metabolism (University Medical Center Freiburg)

Postdoctoral Fellow – Cell Therapy and Bone Tissue Engineering (Etablissement Français du Sang Ile de France)

PhD Studentship – Mesenchymal Stem Cells (University of York)

Mesenchymal Stem Cell (MSC) Laboratory Technician (California Cryobank)

Clinical Laboratory Scientist – Umbilical Cord Blood Processing (California Cryobank)

Animal Surgery – Regenerative Medicine for Cardiac and Skeletal Muscle Disease (Duke University)

Postdoctoral Fellow – Physiology and Pharmacology of Human Skeletal Muscle Microtissues (Duke University)

Quality Improvement Coordinator – Regenerative Medicine (The University of Texas Health Science Center at Houston)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

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