Necrotic Cell-Derived High Mobility Group Box 1 Attracts Antigen-Presenting Cells but Inhibits Hepatocyte Growth Factor-Mediated Tropism of Mesenchymal Stem Cells for Apoptotic Cell Death Researchers investigated the influence of apoptotic and necrotic cell death on recruitment of mesenchymal stem cells, monocytes and immature dendritic cells, and identified hepatocyte growth factor and the alarmin high mobility group box 1 as key factors differentially regulating these migratory responses. [Cell Death Differ] Abstract Diabetes Reduces Mesenchymal Stem Cells in Fracture Healing through a TNFα-Mediated Mechanism Researchers examined the impact of diabetes on mesenchymal stem cells (MSCs) during fracture repair. Diabetes significantly increased TNFα levels and reduced MSC numbers in new bone area. [Diabetologia] Abstract Unexpected Complication in a Rat Stroke Model: Exacerbation of Secondary Pathology in the Thalamus by Subacute Intraarterial Administration of Human Bone Marrow-Derived Mesenchymal Stem Cells Scientists examined whether human bone marrow mesenchymal stromal/stem cells could alleviate the secondary pathology in the thalamus after middle cerebral artery occlusion in rats. [J Cereb Blood Flow Metab] Abstract Synergistic Effect of Angiotensin II on Vascular Endothelial Growth Factor-A-Mediated Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells into Endothelial Cells Scientists investigated a novel role of angiotensin signaling in enhancing vascular endothelial growth factor-A-mediated differentiation of mesenchymal stem cells into endothelial cells. [Stem Cell Res Ther] Abstract | Full Article Suspension-Expansion of Bone Marrow Results in Small Mesenchymal Stem Cells Exhibiting Increased Transpulmonary Passage following Intravenous Administration Researchers explored whether the expansion of whole-marrow in suspension cultures would yield smaller mesenchymal stem cells with increased capacity to traverse the pulmonary microcirculation compared to traditional monolayer cultures. [Tissue Eng Part C Methods] Abstract Crucial Role of IL1beta and C3a in the In Vitro-Response of Multipotent Mesenchymal Stromal Cells to Inflammatory Mediators of Polytrauma Scientists investigated the effects of a defined serum-free polytrauma “cocktail” containing IL1beta, IL6, IL8 and the anaphylatoxins C3a and C5a, in concentrations corresponding to those measured in the blood of polytrauma patients, on human mesenchymal stromal cells in vitro. [PLoS One] Full Article Multidifferentiation Potential of Human Mesenchymal Stem Cells from Adipose Tissue and Hamstring Tendons for Musculoskeletal Cell-Based Therapy Human tendon stem/progenitor cells and adipose-derived stem cells were isolated from hamstring tendon portions and adipose tissue of healthy donors undergoing ACL reconstruction or liposuction, respectively. Clonogenic ability, immunophenotype and multi-differentiation potential were assessed and compared. [Regen Med] Abstract Decellularized ECM Effects on Human Mesenchymal Stem Cell Stemness and Differentiation Scientists addressed effects extracellular matrices (ECMs) deposited by a variety of cell types and decellularized with a cold-EDTA protocol have on multipotent human mesenchymal stromal/stem cell behavior and differentiation. [Differentiation] Abstract Fucoidan Promotes Osteoblast Differentiation via JNK- and ERK-Dependent BMP2-Smad 1/5/8 Signaling in Human Mesenchymal Stem Cells Researchers investigated the action of fucoidan on osteoblast differentiation in human alveolar bone marrow-derived mesenchymal stem cells and its impact on signaling pathways. [Exp Mol Med] Full Article Calcitonin Gene-Related Peptide Stimulates Proliferation and Osteogenic Differentiation of Osteoporotic Rat-Derived Bone Mesenchymal Stem Cells Researchers investigated the role of calcitonin gene-related peptide (CGRP) on bone mesenchymal stem cells (BMSCs) isolated from female osteoporotic rats. Data showed that CGRP stimulated cell proliferation and inhibited cell apoptosis for short-term culture of BMSCs. [Mol Cell Biochem] Abstract |