Mesenchymal Cell News Volume 7.15 | Apr 21 2015

Microencapsulated Equine Mesenchymal Stromal Cells Promote Cutaneous Wound Healing In Vitro
Researchers evaluated the in vitro effects of equine mesenchymal stromal cells (MSC)-derived conditioned medium (CM), containing all factors secreted by MSC, on equine dermal fibroblasts, a cell type critical for successful wound healing, and explored the potential of microencapsulated equine MSC to deliver CM to wounded cells in vitro. [Stem Cell Res Ther] Abstract | Full Article

Mouse Aorta-Derived Mesenchymal Progenitor Cells Contribute to and Enhance the Immune Response of Macrophage Cells under Inflammatory Conditions
To examine the consequence of vascular-tissue progenitor cell-macrophage cell interactions in an inflammatory environment, researchers used a recently established mesenchymal progenitor cell line derived from the mouse aorta. [Stem Cell Res Ther] Abstract | Full Article

Effect of Organic Acids on Calcium Phosphate Nucleation and Osteogenic Differentiation of Human Mesenchymal Stem Cells on Peptide Functionalized Nanofibers
Scientists investigated the effect of organic acids on calcium phosphate (CaP) nucleation on nanofiber microsheets functionalized with a glutamic acid peptide and osteogenic differentiation of human mesenchymal stem cells seeded on the CaP-nucleated microsheets. [Langmuir] Abstract

The Effects of Naproxen on Chondrogenesis of Human Mesenchymal Stem Cells
Scientists determined the effect of Naproxen on collagen type X gene expression and investigated the intracellular signaling pathways that mediate such effect in normal human mesenchymal stem cells during chondrogenesis. [Tissue Eng Part A] Abstract

Human Vascular Wall Mesenchymal Stromal Cells Contribute to Abdominal Aortic Aneurysm Pathogenesis through an Impaired Immunomodulatory Activity and Increased Levels of Matrix Metalloproteinase-9
Investigators verified the presence and contribution of mesenchymal stromal cells (MSCs) to aneurysmal tissue remodeling. MSCs were successfully isolated from the abdominal aortic aneurysm wall of 12 male patients and were found to express mesenchymal and stemness markers. [Circ J] Full Article

Simvastatin Modulates Mesenchymal Stromal Cell Proliferation and Gene Expression
The authors showed that simvastatin negatively modulates mesenchymal stromal cell (MSC) proliferation in a dose-dependent way and regulates the expression of proliferation-related genes. They observed that simvastatin increased the percentage of a subset of smaller MSCs, which also were actively proliferating. [PLoS One] Full Article

TAp63γ and ΔNp63β Promote Osteoblastic Differentiation of Human Mesenchymal Stem Cells: Regulation by Vitamin D3 Metabolites
Researchers compared the endogenous expression of p63 isoforms (TA- and ΔNp63) and splice variants (p63α, -β, -γ), in naive human mesenchymal stem cells (hMSC) and during osteoblastic differentiation of hMSC. TAp63α and -β were the predominant p63 variants in naive, proliferating hMSC. In contrast, under osteoblastic differentiation conditions, expression of p63 changed from the TAp63α and -β to the TAp63γ and ΔNp63β variants. [PLoS One] Full Article

Mesenchymal Stem Cell Based Therapy for Non-Healing Wounds: Today and Tomorrow
The authors summarize the mechanisms of mesenchymal stem cells (MSCs) and highlight the important preclinical and clinical trials of MSC therapy for non-healing wounds. [Wound Repair Regen] Abstract

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Mount Sinai Receives $8.8 Million Grant to Further Stem Cell Research
An $8.8 million grant from the New York State Stem Cell Science Program will accelerate efforts by the Icahn School of Medicine at Mount Sinai to develop new stem-cell-based treatments for chemotherapy-resistant blood cancer and other genetic blood disorders. [Icahn School of Medicine at Mount Sinai] Press Release

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Research Associate: Mesenchymal (STEMCELL Technologies Inc.)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

PhD Position – Biomaterials & Regenerative Medicine (Florida Atlantic University)

Faculty Positions – Stem Cell & Regenerative Medicine (The University of Texas Medical School at Houston)

Postdoctoral Position – Stem Cells (Technion – Israel Institute of Technology)

PhD Positions – Cartilage Regeneration in Joints and Intervertebral Disc Diseases (AO Research Institute)

Postdoctoral Fellowship – Hematology, Immunology, Stem Cell Transplantation, Cancer Therapeutics (The Research Institute at Nationwide Children’s Hospital)

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Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

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