Mesenchymal Cell News Volume 7.19 | May 19 2015

Propagation of Pure Fetal and Maternal Mesenchymal Stromal Cells from Terminal Chorionic Villi of Human Term Placenta
Scientists demonstrated the presence of fetal and maternal cells within the tips of terminal chorionic villi of normal human term placenta, and they exploited inherent differences in the adhesive and migratory properties of maternal vs. fetal cells, to establish pure mesenchymal stromal cell cultures of both cell types. [Sci Rep] Full Article

Finding and Tracing Human MSC in 3D Microenvironments with the Photoconvertible Protein Dendra2
A simple and reliable imaging technique was developed to study mesenchymal stem/stromal cell (MSC) dynamical behavior in natural and bioengineered 3D matrices. Human MSC were transfected to express a fluorescent photoswitchable protein, Dendra2, which was used to highlight and follow the same group of cells for more than seven days, even if removed from the microscope to the incubator. [Sci Rep] Full Article

Human Endometrial Mesenchymal Stem Cells Restore Ovarian Function through Improving the Renewal of Germline Stem Cells in a Mouse Model of Premature Ovarian Failure
Mouse ovaries were injured with busulfan and cyclophosphamide to create a damaged ovary mouse model. Transplanted endometrial mesenchymal stem cells were injected into the tail vein of sterilized mice, or culture medium was injected into the sterilized mice via the tail vein as chemoablated group. [J Transl Med]
Abstract | Full Article

Freshly Thawed and Continuously Cultured Human Bone Marrow-Derived Mesenchymal Stromal Cells Comparably Ameliorate Allergic Airways Inflammation in Immunocompetent Mice
Scientists compared freshly thawed versus continuously cultured human bone marrow-derived mesenchymal stromal cell administration in a mouse model of mixed Th2/Th17 allergic airway inflammation induced by Aspergillus hyphal extract exposures in immunocompetent C57Bl/6 mice. [Stem Cells Transl Med] Abstract

Transcriptional Dynamics of Immortalized Human Mesenchymal Stem Cells during Transformation
Scientists performed whole transcriptome analysis to the human mesenchymal stem cell line, UE6E7T-3, which was immortalized with hTERT and human papillomavirus type 16 E6/E7 genes, in association with progress of transformation in these cells. [PLoS One] Full Article

Epigallocatechin-3-Gallate-Induced Free-Radical Production upon Adipogenic Differentiation in Bovine Bone-Marrow Mesenchymal Stem Cells
Investigators explored the variability in free-radical production in bovine bone-marrow mesenchymal stem cells (BMSCs) treated with epigallocatechin-3-gallate (EGCG). Upon adipogenic differentiation, BMSCs were exposed to various EGCG concentrations. [Cell Tissue Res] Abstract

Regulative Effect of mir-205 on Osteogenic Differentiation of Bone Mesenchymal Stem Cells (BMSCs): Possible Role of SATB2/Runx2 and ERK/MAPK Pathway
Researchers investigated the role of mir-205 in the osteogenic differentiation of BMSCs. They found that mir-205 expression was down-regulated in a time-dependent manner during BMSC osteo-induction. [Int J Mol Sci] Abstract | Download Full Article

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Pluristem’s PLX Cells One Step Closer to Entering Japan’s Accelerated Pathway for Regenerative Medicine
Pluristem Therapeutics Inc. announced that Japan’s Pharmaceuticals and Medical Devices Agency agreed with the proposed quality and large-scale manufacturing methods for PLX-PAD cells for use in clinical trials. [Pluristem Therapeutics Inc.] Press Release

From our sponsor: Learn how to form and isolate neural rosettes more efficiently. Watch the video.

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Visit our events page to see a complete list of events in the mesenchymal cell community.

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Postdoctoral Position – Biomaterials (University of São Paulo)

Tenure-Track Fellowship – Musculoskeletal Biology (University of Liverpool)

PhD Position – Biomaterials & Regenerative Medicine (Florida Atlantic University)

Faculty Positions – Stem Cell & Regenerative Medicine (The University of Texas Medical School at Houston)

Postdoctoral Position – Stem Cells (Technion – Israel Institute of Technology)

Postdoctoral Fellowship – Hematology, Immunology, Stem Cell Transplantation, Cancer Therapeutics (The Research Institute at Nationwide Children’s Hospital)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

Recruit Top Talent: Reach more than 60,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.