Mesenchymal Cell News Volume 7.36 | Sep 15 2015

Electro-Magnetic Field Promotes Osteogenic Differentiation of BM-hMSCs through a Selective Action on Ca²⁺-Related Mechanisms
Scientists investigated the in vitro effect of pulsed electromagnetic field on Ca²⁺-related mechanisms promoting the osteogenic differentiation of human mesenchymal stem cells derived from bone marrow stroma (BM-hMSCs). [Sci Rep] Full Article

GPR120: A Bi-Potential Mediator to Modulate the Osteogenic and Adipogenic Differentiation of BMMSCs
The authors showed that GPR120 targeted the bi-potential differentiation of bone marrow mesenchymal stem cells (BMMSCs) in a ligand dose-dependent manner. [Sci Rep] Full Article

Transplantation of Hypoxia Preconditioned Bone Marrow Mesenchymal Stem Cells Enhances Angiogenesis and Osteogenesis in Rabbit Femoral Head Osteonecrosis
Investigators explored the novel strategy of hypoxia-preconditioned bone marrow mesenchymal stem cell (BMMSCs) to reverse the impairment of osteonecrosis BMMSCs and enhance the therapeutic potential of hypoxia-treated BMMSC transplantation. [Bone] Abstract

The Efficacy of Polycaprolactone/Hydroxyapatite Scaffold in Combination with Mesenchymal Stem Cells for Bone Tissue Engineering
Scientists determined the ability of polycaprolactone/hydroxyapatite for supporting cell growth, gene expression, and osteogenic differentiation in three types of mesenchymal stem cells, including bone marrow-derived mesenchymal stem cells, dental pulp stem cells and adipose-derived mesenchymal stem cells. [J Biomed Mater Res A] Abstract

Carbon Nanoparticle Induced Cytotoxicity in Human Mesenchymal Stem Cells through Upregulation of TNF3, NFKBIA and BCL2L1 genes
The authors focused on the cellular toxicity of carbon nanoparticles (CNPs) on human mesenchymal stem cells. Following exposure to CNPs, cell viability, nuclear morphological changes, apoptosis and cell cycle progression were monitored. [Chemosphere] Abstract

Overexpression of Hif-1α in Mesenchymal Stem Cells Affects Cell-Autonomous Angiogenic and Osteogenic Parameters
Investigators overexpressed Hypoxia-inducible factor 1 (Hif-1)α in mesenchymal stem cells by using recombinant adenoviruses and investigated cell-autonomous effects. Overexpression of Hif-1α enhanced proliferation, migration, cell survival and expression of pro-angiogenic genes. [J Cell Biochem] Abstract

Human Mesenchymal Stem Cells Retain Multilineage Differentiation Capacity Including Neural Marker Expression after Extended In Vitro Expansion
To identify potential therapeutic suitability researchers examined human mesenchymal stem cells after extended expansion including morphological changes, potency and multilineage potential. [PLoS One] Full Article

Canine Platelet Lysate Is Inferior to Fetal Bovine Serum for the Isolation and Propagation of Canine Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stromal Cells
Scientists hypothesized that canine adipose tissue and bone marrow mesenchymal stromal cells (MSC) could be isolated and expanded equally in platelet lysate and fetal bovine serum at conventionally-used concentrations with differentiation of these MSC unaffected by choice of supplement. [PLoS One] Full Article

Multi-Lineage Potential Research of Bone Marrow Mesenchymal Stem Cells from Bama Miniature Pig
Bone marrow was collected from Bama miniature pigs to isolate bone marrow mesenchymal stem cells by a whole bone marrow culture method. They then examined their biological characteristics such as growth kinetics, surface antigen, and multi-lineage potential. [J Exp Zool B Mol Dev Evol] Abstract

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Ogawa-Yamanaka Prize Founded at the Gladstone Institutes to Support Translational Stem Cell Research
The Gladstone Institutes presented the inaugural Ogawa-Yamanaka Stem Cell Prize to Masayo Takahashi, MD, PhD, a faculty member and project leader in the Laboratory for Retinal Regeneration at the RIKEN Centre for Developmental Biology in Japan. Dr. Takahashi was awarded the prize for her trailblazing work leading the first clinical trial to use induced pluripotent stem cells in humans. [Gladstone Institutes] Press Release

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Faculty Position – Life Sciences (Stowers Institute for Medical Research)

Faculty Positions – Stem Cells and Regenerative Medicine (King Abdullah University of Science and Technology)

Postdoctoral Fellow – Cardiovascular Stem Cell Biology and Tissue Engineering (Yale University)

Junior Group Leader – Cell and Development Biology Program (Centre for Genomic Regulation)

Professorship – Cellular and/or Molecular Biology and Immunology (Nanjing University)

Cell Biology Lab Manager (Harvard Apparatus Regenerative Technology)

Postdoctoral Fellow – Stem Cell Biology (INSERM)

Postdoctoral Position – Stem Cells (Technion – Israel Institute of Technology)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

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