Mesenchymal Cell News Volume 7.37 | Sep 22 2015

Systemic Administration of Human Bone Marrow-Derived Mesenchymal Stromal Cell Extracellular Vesicles Ameliorates Aspergillus Hyphal Extract-Induced Allergic Airway Inflammation in Immunocompetent Mice
Scientists determined whether xenogeneic administration of conditioned media or extracellular vesicles from human bone marrow-derived mesenchymal stromal cells would be effective in a model of mixed Th2/Th17, neutrophilic-mediated allergic airway inflammation, reflective of severe refractory asthma, induced by repeated mucosal exposure to Aspergillus hyphal extract in immunocompetent C57Bl/6 mice. [Stem Cells Transl Med] Abstract

Bone Marrow-Derived Mesenchymal Stem Cells Ameliorate Chronic High Glucose-Induced β-Cell Injury through Modulation of Autophagy
Researchers investigated whether bone marrow-derived mesenchymal stem cells could ameliorate chronic high glucose-induced β-cell injury through modulation of autophagy. [Cell Death Dis] Full Article

Olfactory Ecto-Mesenchymal Stem Cells Possess Immunoregulatory Function and Suppress Autoimmune Arthritis
Investigators found that mouse olfactory ecto-mesenchymal stem cells (MSCs) expressed higher transforming growth factor-beta and interleukin-10 levels than bone marrow-derived MSCs. [Cell Mol Immunol] Abstract

Correlation between In Vitro Expansion-Related Cell Stiffening and Differentiation Potential of Human Mesenchymal Stem Cells
Human mesenchymal stem cells were cultured and routinely passaged on tissue-culture polystyrene to investigate the correlation between cell stiffening and differentiation potency during in vitro aging. [Differentiation] Abstract

Preparation and Characterization of Directed, One-Day-Self-Assembled Millimeter-Size Spheroids of Adipose-Derived Mesenchymal Stem Cells
Scientists prepared millimeter-order spheroids of adipose-derived mesenchymal stem cells (ADSCs) by controlling the spheroid size. Notably, spheroid generation required only one-day of culture on charged culture dishes. Almost all spheroid-derived ADSCs were viable and produced adhesion molecules and growth factors, which play an important role in tissue regeneration. [J Biomed Mater Res A] Abstract

Basic Fibroblast Growth Factor Stimulates the Proliferation of Bone Marrow Mesenchymal Stem Cells in Giant Panda (Ailuropoda melanoleuca)
Researchers investigated the role of basic fibroblast growth factor (bFGF) on the proliferation of bone marrow-mesenchymal stem cells (MSCs) derived from giant panda. MSCs were cultured for cell proliferation analysis at 24, 48 and 72 hours following the addition of bFGF. [PLoS One] Full Article

Treatment of Perianal Fistulas with Human Embryonic Stem Cell-Derived MSCs: A Canine Model of Human Fistulizing Crohn’s Disease
Investigators evaluated the safety and efficacy of intralesional injection of human embryonic stem cell-derived mesenchymal stem/stromal cells (MSCs) in canine anal furunculosis dogs. [Regen Med]
Full Article | Press Release

Single CD271 Marker Isolates Mesenchymal Stem Cells from Human Dental Pulp
Investigators used different combinations of surface markers to isolate homogeneous populations of dental mesenchymal stem cells from heterogeneous dental pulp cells obtained from dental pulp tissue and compared their capacity to undergo multilineage differentiation. [Int J Oral Sci] Full Article

Recent Advances in Serum-Free Microcarrier Expansion of Mesenchymal Stromal Cells: Parameters to Be Optimized
Mesenchymal stromal cells are being investigated for a variety of therapeutic indications. However, current 2D planar technology cannot meet the anticipated demand and a shift to serum-free microcarrier cultures is needed in order to meet the quality and quantity of cells required. The authors summarize several recent attempts to grow cells in such conditions, and identify several variables that affect cell expansion. [Biochem Biophys Res Commun] Full Article

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Federal Initiative Could Further Boost Personalized Medicine in U.S.
Hosted and funded by the California Institute for Regenerative Medicine, the Stem Cell Bank in Novato will have 300 stem cell lines available immediately and will expand to 750 lines by February 2016. The repository will enable scientists to examine stem cells representing autism, epilepsy and other childhood neurological disorders; blinding eye diseases; heart, lung and liver diseases; Alzheimer’s disease, and relevant control samples. [Rainbow BioSciences] Press Release

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Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

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Faculty Positions – Stem Cells and Regenerative Medicine (King Abdullah University of Science and Technology)

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