Steric Interference of Adhesion Supports In Vitro Chondrogenesis of Mesenchymal Stem Cells on Hydrogels for Cartilage Repair Researchers determined if a polyethylene glycol-modified fibrinogen matrix could support better chondrogenesis of human bone marrow mesenchymal stem cells based on steric interference of adhesion, when compared to a natural fibrin matrix. [Sci Rep] Full Article Estrogen Receptor Mediates Simvastatin-Stimulated Osteogenic Effects in Bone Marrow Mesenchymal Stem Cells Investigators hypothesized that the estrogen receptor (ER) mediates simvastatin-induced osteogenic differentiation. ER antagonists and siRNA were used to determine the involvement of the ER in simvastatin-induced osteogenesis in mouse bone marrow mesenchymal stem cells. [Biochem Pharmacol] Abstract Preameloblast-Derived Factors Mediate Osteoblast Differentiation of Human Bone Marrow Mesenchymal Stem Cells via Runx2-Osterix-BSP Signaling The authors investigated the effects of preameloblast-conditioned medium on human bone marrow mesenchymal stem cells in vitro, and investigated the bone regenerative capacity in vivo through epithelial-mesenchymal interactions of developmental osteogenesis. [Tissue Eng Part A] Abstract In Vitro Migration and Proliferation (“Wound Healing”) Potential of Mesenchymal Stromal Cells Generated from Human CD271+ Bone Marrow Mononuclear Cells The in vitro model of wound healing was used in order to compare the migration and proliferation potential of mesenchymal stromal cells (MSCs) generated from positively selected CD271+ bone marrow mononuclear cells and MSCs generated by plastic adherence of passage two and four cultured in presence or absence of growth factors or cytokines. [J Transl Med] Full Article MicroRNA-498 Inhibition Enhances the Differentiation of Human Adipose-Derived Mesenchymal Stem Cells into Podocyte-Like Cells The authors established a two-stage induction protocol for podocytes generation from human adipose-derived mesenchymal stem cells (hAD-MSCs). They initially established a condition that induce hAD-MSCs toward intermediate mesoderm cells with activin A and high concentration of RA. [Stem Cells Dev] Abstract IL-21-Expressing Mesenchymal Stem Cells Prevent Lethal B-Cell Lymphoma through Efficient Delivery of IL-21, which Redirects the Immune System to Target the Tumor The authors hypothesized that mesenchymal stem cells, genetically modified to express high levels of interleukin (IL)-21, can enhance anti-tumor responses through localized delivery of IL-21. [Stem Cells Dev] Abstract Differential Osteogenic Potential of Human Adipose-Derived Stem Cells Co-Cultured with Human Osteoblasts on Polymeric Microfiber Scaffolds The osteogenic potential of human adipose derived stem cells (HADSCs) co-cultured with human osteoblasts (HOBs) using selected HADSCs/HOBs ratios of 1:1, 2:1 and 1:2 respectively was evaluated. [J Biomed Mater Res A] Abstract Mesenchymal Stromal Cells for Sphincter Regeneration: Role of Laminin Isoforms upon Myogenic Differentiation The laminin family consists of 16 functionally different isoforms with LM-211 being the most abundant isoform of adult muscle tissues. All laminin isoforms tested showed a significant inhibition of the proliferation of undifferentiated mesenchymal stromal cells (MSCs) but, with the exception of LM-521, they had no influence on the proliferation of MSCs cultivated in myogenic medium. [PLoS One] Full Article Disparate Effects of Mesenchymal Stem Cells in Experimental Autoimmune Encephalomyelitis and Cuprizone-Induced Demyelination As the pathogeneses of multiple sclerosis and experimental autoimmune encephalomyelitis are thought to be mediated by IFNγ-producing and IL-17A-producing effector CD4+ T cells, scientists investigated the effect of mesenchymal stem cells on the development of these two key pathogenic cell groups. [PLoS One] Full Article Mesenchymal Stem Cells of Different Origin: Comparative Evaluation of Proliferative Capacity, Telomere Length and Pluripotency Marker Expression The authors characterized and compared proliferation, differentiation, telomere length and pluripotency marker expression in mesenchymal stem cells of various origins. [Life Sci] Abstract |