Mesenchymal Cell News Volume 7.40 | Oct 13 2015

Scaffold-Free, Human Mesenchymal Stem Cell-Based Tissue Engineered Blood Vessels
Hypothesizing that a scaffold-free tissue-engineered blood vessel may be advantageous, scientists constructed a tubular structure from aligned human mesenchymal cell sheets as the wall and human endothelial progenitor cell coating as the lumen. [Sci Rep] Full Article

Alleviation of Apoptosis of Bone Marrow-Derived Mesenchymal Stem Cells in the Acute Injured Kidney by Heme Oxygenase-1 Gene Modification
Acute kidney injury-kidney homogenate supernatant resulted in a high inhibitory rate of bone marrow-derived mesenchymal stem cells (BMSCs) growth and a high proportion of TUNEL positive BMSCs, while heme oxygenase-1 (HO-1) overexpression inversed this phenomenon and re-established the antioxidant and oxidant balance in HO-1-BMSCs. [Int J Biochem Cell Biol] Abstract

Role of Helicobacter pylori on Cancer of Human Adipose-Derived Mesenchymal Stem Cells and Metastasis of Tumor Cells — An In Vitro Study
The authors aimed to find the effects of H. pylori on human adipose-derived mesenchymal stem cells (MSCs) transforming toward cancer cells and also metastasis of tumor cells by synergic effects of H. pylori and gastric epithelial cells on MSCs. [Tumour Biol] Abstract

Roles of MicroRNA-34a Targeting SIRT1 in Mesenchymal Stem Cells
Scientists showed that microRNA-34a (miR-34a) was significantly up-regulated under hypoxia and serum deprivation conditions in mesenchymal stem cells, while overexpression of miR-34a was significantly associated with increased apoptosis, impaired cell vitality and aggravated senescence. [Stem Cell Res Ther] Full Article

Comparative Analysis of Human Mesenchymal Stem Cells Derived from Bone Marrow, Placenta and Adipose Tissue as Sources of Cell Therapy
Scientists characterized mesenchymal stem cells from different sources, including human bone marrow, placenta, and adipose tissue, in terms of the phenotype, surface antigen expression, differentiation ability, proteome reference map and blood flow recovery in a hindlimb ischemic disease model. [J Cell Biochem] Abstract

Microenvironmental Interaction between Hypoxia and Endothelial Cells Controls the Migration Ability of Placenta-Derived Mesenchymal Stem Cells via Alpha4 Integrin and Rho Signaling
Researchers compared the expression of markers related to integrin-mediated signaling in placenta-derived mesenchymal stem cells dependent on hypoxia and co-cultured with human umbilical vein endothelial cells and evaluated their correlations between migration ability and microenvironmental factors including hypoxia and endothelial cells. [J Cell Biochem] Abstract

Prospectively Defined Murine Mesenchymal Stem Cells Inhibit Klebsiella pneumoniae-Induced Acute Lung Injury and Improve Pneumonia Survival
Researchers demonstrated for the first time the feasibility and in vivo immunomodulatory capacity of prospectively defined mesenchymal stem cells in pneumonia. [Respir Res] Full Article

Bone Regeneration in Calvarial Defects in a Rat Model by Implantation of Human Bone Marrow-Derived Mesenchymal Stromal Cell Spheroids
The authors investigated bone regeneration in rats using the human bone marrow-derived mesenchymal stem cell-spheroids prepared by rotation culture, without synthetic or exogenous biomaterials. [J Mater Sci Mater Med] Full Article

Engraftability of Murine Bone Marrow-Derived Multipotent Mesenchymal Stem Cell Subpopulations in the Tissues of Developing Mice following Systemic Transplantation
Investigators generated single-cell subpopulations of mesenchymal stems cells from murine bone marrow and assessed them for differences in trafficking through the circulatory system and engraftment in bone and other tissues. [Cells Tissues Organs] Abstract

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BrainStorm Announces Treatment of Final Patient in US Multicenter Double Blinded Phase II ALS Trial
BrainStorm Cell Therapeutics Inc. announced that the final patient has been treated in its multicenter Phase II clinical trial investigating the company’s proprietary NurOwn™ stem cell technology. [BrainStorm Cell Therapeutics Inc. (PR Newswire Association LLC)] Press Release

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Postdoctoral Position – Bone Research (Weill Cornell College of Medicine)

Postdoctoral Position – Stem Cell Research (Karolinska Institute)

Assistant Professor – Stem Cell Biology (University of South Carolina)

Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

Faculty Position – Life Sciences (Stowers Institute for Medical Research)

Faculty Positions – Stem Cells and Regenerative Medicine (King Abdullah University of Science and Technology)

Postdoctoral Fellow – Cardiovascular Stem Cell Biology and Tissue Engineering (Yale University)

Junior Group Leader – Cell and Development Biology Program (Centre for Genomic Regulation)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

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