IN VITRO Up-Regulation of Immunomodulatory Effects of Mouse Bone-Marrow Derived Mesenchymal Stem Cells by Tetrahydrocannabinol Pre-Treatment Involving Cannabinoid Receptor CB2 Scientists found that tetrahydrocannabinol activated cannabinoid receptor type 2 (CB2) receptor and ERK signaling, consequently enhancing the modulation of mesenchymal stem cells on inflammation-associated cytokine release from lipopolysaccharides-stimulated microglia. [Oncotarget] Full Article Alginate-Encapsulation for the Improved Hypothermic Preservation of Human Adipose-Derived Stem Cells Researchers examined whether hypothermic preservation of human adipose-derived stem cells could be improved through their encapsulation in 1.2% calcium alginate. Alginate encapsulation improved the recovery of viable cells after 72 hours of storage. [Stem Cells Transl Med] Abstract | Press Release MicroRNA-27b Enhances the Hepatic Regenerative Properties of Adipose-Derived Mesenchymal Stem Cells Scientists investigated the mechanistic role of how miR-27b modulated regenerative capacities of adipose-derived mesenchymal stem cells (ASCs). Intravenous administration of miR-27b-transfected ASCs was conducted after 70% partial hepatectomy. [Mol Ther Nucleic Acids] Full Article A Systematic Study of the Effect of Different Molecular Weights of Hyaluronic Acid on Mesenchymal Stromal Cell-Mediated Immunomodulation Mesenchymal stromal cells (MSCs) are often delivered with hyaluronic acid (HA), although the combined mechanism of action is not fully understood; the authors thus investigated the immunomodulatory effects of combining MSCs with different molecular weights of HA. [PLoS One] Full Article BPA-Toxicity via Superoxide Anion Overload and a Deficit in β-Catenin Signaling in Human Bone Mesenchymal Stem Cells Bisphenol A (BPA) increased cytotoxicity in human bone mesenchymal stem cells in a dose- and time-dependent manner, concomitantly with increased lipid peroxidation. [Environ Toxicol] Abstract IN VIVO Soluble Tumor Necrosis Factor Receptor 1 Released by Skin-Derived Mesenchymal Stem Cells Is Critical for Inhibiting Th17 Cell Differentiation Investigators demonstrated that the intraperitoneal administration of skin-derived mesenchymal stem cells substantially ameliorated the development of experimental autoimmune encephalomyeliti in mice. [Stem Cells Transl Med] Abstract Wnt11 Plays an Important Role in the Osteogenesis of Human Mesenchymal Stem Cells in a PHA/FN/ALG Composite Scaffold: Possible Treatment for Infected Bone Defect Tissue-engineered bone was constructed with human mesenchymal stem cells and porous hydroxyapatite/fibronectin/alginate (PHA/FN/ALG) composite scaffolds, and then was implanted into an infected bone defect model for evaluating the osteogenic capacity by quantitative PCR, gross observation, micro-CT and histology analysis. [Stem Cell Res Ther] Full Article TOB1 Deficiency Enhances the Effect of Bone Marrow-Derived Mesenchymal Stem Cells on Tendon-Bone Healing in a Rat Rotator Cuff Repair Model The authors investigated the effect of silencing TOB1 (Transducer of ERBB2, 1) expression in bone marrow-derived mesenchymal stem cells (MSCs) on MSC-facilitated tendon-bone healing in a rat supraspinatus repair model. [Cell Physiol Biochem] Full Article |