IN VITRO Mouse Mesenchymal Stem Cells Inhibit High Endothelial Cell Activation and Lymphocyte Homing to Lymph Nodes by Releasing TIMP-1 The authors showed that the endothelium is a specific and key target of mesenchymal stem cells (MSC) during immunity and inflammation. In mice, MSC inhibit activation and proliferation of endothelial cells in remote inflamed lymph nodes, affect elongation and arborization of high endothelial venules and inhibit T cells homing. [Leukemia] Abstract | Full Article ECM Microenvironment Unlocks Brown Adipogenic Potential of Adult Human Bone Marrow-Derived MSCs Researchers showed that macromolecular crowding facilitates brown adipocyte differentiation in adult human bone marrow mesenchymal stem cells, as evidenced by substantially upregulating uncoupling protein 1 and uncoupled respiration. [Sci Rep] Full Article The T-Box Transcription Factor 3 Is a Promising Biomarker and a Key Regulator of the Oncogenic Phenotype of a Diverse Range of Sarcoma Subtypes Researchers showed that a diverse subset of soft tissue and bone sarcoma cell lines and patient-derived sarcoma tissues express high levels of TBX3. They further explore the significance of this overexpression using a small interfering RNA approach and demonstrate that TBX3 promotes the migratory ability of chondrosarcoma, rhabdomyosarcoma and liposarcoma cells but inhibits fibrosarcoma cell migration. [Oncogenesis] Full Article Fibroblast Growth Factor 2 Regulates High Mobility Group A2 Expression in Human Bone Marrow-Derived Mesenchymal Stem Cells Using an isolation method to obtain pure mesenchymal stem cells (MSCs) within nine days in culture, investigators showed that expression of HMGA2 quickly decreases during early expansion of MSCs, while let-7 microRNAs (which repress HMGA2) are simultaneously increased. [J Cell Biochem] Abstract IN VIVO Intraluminal Injection of Mesenchymal Stromal Cells in Spheroids Attenuates Experimental Colitis Researchers aggregated mesenchymal stromal cells (MSCs) in vitro into spheroids and injected them intraluminally in mice with established colitis to investigate whether these MSC spheroids could alleviate the colitis. [J Crohns Colitis] Abstract Therapeutic Efficacy of Apelin on Transplanted Mesenchymal Stem Cells in Hindlimb Ischemic Mice via Regulation of Autophagy Scientists demonstrated that apelin promoted functional survival of adipose derived mesenchymal stem cells (AD-MSCs) in ischemic hindlimbs and provoked a synergetic effect with AD-MSCs to restore hindlimb blood perfusion and limb functions. [Sci Rep] Full Article Comparison of Survival and Osteogenic Ability of Human Mesenchymal Stem Cells in Orthotopic and Ectopic Sites in Mice Osteoconductive coral scaffold with or without luciferase-labelled human mesenchymal stem cells were implanted either in a critical-segmental-femoral-bone defect stabilized by plate or subcutaneously in 44 mice. Cell survival was evaluated by serial bioluminescence imaging and osteogenic capabilities by histology and microCT. [Tissue Eng Part A] Abstract An Endochondral Ossification-Based Approach to Bone Repair: Chondrogenically-Primed MSC-Laden Scaffolds Support Greater Repair of Critical-Sized Cranial Defects than Osteogenically Stimulated Constructs In Vivo The authors hypothesized that stimulation of mesenchymal stem cell (MSC) chondrogenesis and subsequent hypertrophy within collagen-based scaffolds would lead to improved vascularization and bone formation when implanted within a critical-sized bone defect in vivo. [Tissue Eng Part A] Abstract Allogeneic Mesenchymal Stromal Cells Transplanted onto the Heart Surface Achieve Therapeutic Myocardial Repair Despite Immunologic Responses in Rats Scientists aimed to elucidate immunologic response against epicardially placed allogeneic mesenchymal stromal cells, rejection or acceptance of these cells, and their therapeutic effects for heart failure. [J Am Heart Assoc] Full Article Mesenchymal Stromal Cell–Mediated Neuroprotection and Functional Preservation of Retinal Ganglion Cells in a Rodent Model of Glaucoma Researchers compared the efficacy of adipose-derived stem cells, bone marrow–derived mesenchymal stromal cells and dental pulp stem cells in preventing the loss of retinal ganglion cells and visual function when transplanted into the vitreous of glaucomatous rodent eyes. [Cytotherapy] Abstract Treatment of Fecal Incontinence Using Allogeneic-Adipose-Derived Mesenchymal Stem Cells: A Study Protocol for a Pilot Randomized Controlled Trial Researchers investigated the safety and efficacy of using allogeneic-adipose-derived mesenchymal stem cells in the treatment of the anal sphincter of patients with faecal incontinence. [BMJ Open] Full Article |