Mesenchymal Cell News Volume 8.19 | May 17 2016

Mechanical Stimulation Orchestrates the Osteogenic Differentiation of Human Bone Marrow Stromal Cells by Regulating HDAC1
Scientists investigated whether mechanical loading regulates histone deacetylase (HDAC) expression directly and examined the role of HDACs in mechanical loading-triggered osteogenic differentiation and bone formation. [Cell Death Dis] Full Article

MicroRNA-99a Regulates Early Chondrogenic Differentiation of Rat Mesenchymal Stem Cells by Targeting the BMPR2 Gene
Researchers showed that expression of miR-99a and miR-125b-3p were increased during early chondrogenic differentiation of mesenchymal stem cells derived from the Norwegian brown rat. MiR-99a knockdown promoted proteoglycan deposition and increased the expression of ACAN and COL2A1 during early chondrogenic differentiation. [Cell Tissue Res] Abstract

Immunomodulatory Properties of Induced Pluripotent Stem Cell-Derived Mesenchymal Cells
Scientists assessed the immunomodulatory potential of induced pluripotent stem cell (iPSC)-MSCs generated from periodontal ligament and gingival tissue. The iPSC-MSC lines exhibited a similar level of suppression of mitogen-stimulated peripheral blood mononuclear cells proliferation compared to their respective parental fibroblast populations in vitro. [J Cell Biochem] Abstract

Comparative Ability of Mesenchymal Stromal Cells from Different Tissues to Limit Neutrophil Recruitment to Inflamed Endothelium
Investigators compared the effects of mesenchymal stromal cells (MSC) isolated from bone marrow, Wharton’s jelly, and trabecular bone on neutrophil recruitment to cytokine-stimulated endothelial cells (EC), using co-culture models with different degrees of proximity between MSC and EC. [PLoS One] Full Article

Gelatin Directly Enhances Neurogenic Differentiation Potential in Bone Marrow-Derived Mesenchymal Stem Cells without Stimulation of Neural Progenitor Cell Proliferation
Investigators determined whether gelatin can directly enhance neurogenic differentiation potential in mesenchymal stem cells (MSCs) without proliferation of neural progenitor cells. MSCs comprised a high proportion of bone marrow-derived primary cells and gelatin induced significant increases in MSC proliferation during primary culture, and the proportion of MSCs was maintained at more than 99% throughout the subculture. [DNA Cell Biol] Abstract

IN VIVO

Enhancement of Tendon-to-Bone Healing after Anterior Cruciate Ligament Reconstruction Using Bone Marrow-Derived Mesenchymal Stem Cells Genetically Modified with bFGF/BMP2
Bone marrow-derived mesenchymal stem cells (BMSCs) were infected with an adenoviral vector encoding bone morphogenetic protein 2 (BMP2) or basic fibroblast growth factor (bFGF). Then, the infected BMSCs were surgically implanted into the tendon-bone interface. [Sci Rep] Full Article

Intraventricular Injections of Mesenchymal Stem Cells Activate Endogenous Functional Remyelination in a Chronic Demyelinating Murine Model
In order to achieve general remyelination in various brain structures simultaneously, bone marrow-derived mesenchymal stem cells were transplanted into the lateral ventricles of the cuprizone murine model. In this manner, the cells may secrete soluble factors into the cerebrospinal fluid and boost the endogenous oligodendrogenic potential of the subventricular zone. [Cell Death Dis] Full Article

Transplantation of Human Adipose-Derived Mesenchymal Stem Cells on a Bladder Acellular Matrix for Bladder Regeneration in a Canine Model
Scientists evaluated human adipose-derived mesenchymal stem cells (hADSCs) combined with a bladder acellular matrix (BAM) for bladder regeneration. A BAM or BAM loaded with hADSCs (BAM/hADSCs) was used to repair partial cystectomy of the bladder in a canine model. [Biomed Mater] Abstract

Synergic Effects of Rehabilitation and Intravenous Infusion of Mesenchymal Stem Cells after Stroke in Rats
The authors investigated whether synergic effects of daily rehabilitation and intravenous infusion of mesenchymal stem cells has therapeutic effects after stroke in rats. [Phys Ther] Abstract

Adipose-Derived Stem Cells as a Tool in Cell-Based Therapies
The authors review the comprehensive information concerning characteristic features of adipose-derived stem cells. They also review the regenerative potential and clinical application based on various clinical trials. [Arch Immunol Ther Exp] Full Article

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

BrainStorm Awarded $1.5 Million Non-Dilutive Grant for 2016 from Israel’s Office of the Chief Scientist
BrainStorm Cell Therapeutics Inc. announced that its wholly-owned subsidiary, Brainstorm Cell Therapeutics Ltd., has been awarded a new grant of approximately $1,470,000 from Israel’s Office of the Chief Scientist. [BrainStorm Cell Therapeutics Inc.] Press Release

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Visit our events page to see a complete list of events in the mesenchymal cell community.

NEW Professor – Hematology and Cell Therapy (Karolinska Institutet)

NEW Postdoctoral Position – Bone/Stem Cell Biology (University of California, Los Angeles)

NEW Postdoctoral Fellow – Skeletal Biology (Perelman School of Medicine)

NEW Postdoctoral Scholar – Neurobiology (Penn State College of Medicine)

Research Technologist – Mesenchymal Stem Cell Biology (STEMCELL Technologies Inc.)

Fellowships – Diabetes and Metabolic Associated Disease Research (Pere Virgili Health Research Institute)

Postdoctoral Fellow – Tissue Regeneration (University of Pennsylvania)

Postdoctoral Researcher – Stem Cell Biology, Regenerative Medicine (NUI Galway)

PhD Student Position – Bone Biology (KU Leuven)

Postdoctoral Position – Craniofacial Molecular Biology (University of Southern California)

Engineering Project Lead (Cytonome)

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