Mesenchymal Cell News Volume 8.22 | Jun 7 2016

TOP STORY

Stromal Tissue Rigidity Promotes Mesenchymal Stem Cell-Mediated Corneal Wound Healing through the Transforming Growth Factor β Signaling Pathway

Mesenchymal stem cells (MSCs) were grown on a matrix with the rigidity of the physiological human vitreous, corneal epithelium, or corneal stroma for investigating the role of corneal tissue rigidity in MSC functions regarding re-epithelialization promotion. [Stem Cells] Abstract

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IN VITRO

EZH2 and HDAC9c Regulate Age-Dependent Mesenchymal Stem Cell Differentiation into Osteoblasts and Adipocytes

Researchers investigated the relationship between age, and osteogenic and adipogenic differentiation potential of mesenchymal stem cells by comparing enhancer of zeste homolog 2 (EZH2) and HDAC9c expression in osteoblasts and adipocytes of both human and mice origins to determine whether the EZH2-HDAC9c axis regulates age-associated osteoporosis and obesity. [Stem Cells] Abstract

Macrophage-Mediated Inflammatory Response Decreases Mycobacterial Survival in Mouse MSCs by Augmenting NO Production

Scientists found that macrophage-mediated inflammatory response during Mycobacterium tuberculosis infection facilitated the clearance of bacilli residing in mouse mesenchymal stem cells (MSCs). Higher inducible nitric oxide synthase expression and nitric oxide (NO) production were observed in mouse MSCs under macrophage-mediated inflammatory circumstance. [Sci Rep] Full Article

Controlled Inhibition of the Mesenchymal Stromal Cell Pro-Inflammatory Secretome via Microparticle Engineering

The authors showed that microparticles loaded with TPCA-1, a small-molecule NF-κB inhibitor, when delivered to human mesenchymal stromal cells can attenuate secretion of pro-inflammatory factors for at least six days in vitro. [Stem Cell Reports] Full Article | Graphical Abstract

Mesenchymal Stem Cells from Human Extra Ocular Muscle Harbor Neuroectodermal Differentiation Potential

Extra ocular muscle (EOM) tissue derived mesenchymal stem cells (MSC) were characterized and compared with bone marrow derived MSC. Scientists found that EOM derived MSC proliferated as a monolayer and showed similarities in morphology, growth properties and cell surface marker expression with bone marrow derived MSC and expressed high levels of NES, OCT4, NANOG and SOX2 in its undifferentiated state. [PLoS One] Full Article

A Comparative Study of Growth Kinetics, In Vitro Differentiation Potential and Molecular Characterization of Fetal Adnexa Derived Caprine Mesenchymal Stem Cells

The present study was conducted with an objective of isolation, in vitro expansion, growth kinetics, molecular characterization and in vitro differentiation of fetal adnexa derived caprine mesenchymal stem cells. [PLoS One] Full Article

The Distinct Effects of Estrogen and Hydrostatic Pressure on Mesenchymal Stem Cells Differentiation: Involvement of Estrogen Receptor Signaling

Researchers investigated the differential and synergistic effects of mechanical stimulation and estrogen on the proliferation and osteogenic or chondrogenic differentiation potential of bone marrow mesenchymal stem cells and the roles of estrogen receptor in them. [Ann Biomed Eng] Abstract

Isolation and Characterization of Rat Mesenchymal Stem Cells Derived from Granulocyte Colony-Stimulating Factor-Mobilized Peripheral Blood

Investigators showed that mobilized mesenchymal stem cells derived from rat peripheral blood overexpress mesenchymal markers, including CD90, CD44, CD29, CD73 and CD105, but do not express CD45, CD11b, CD79a, CD34 or HLA-DR. [Cells Tissues Organs] Full Article

IN VIVO

Clinical Outcomes of Transplanted Modified Bone Marrow–Derived Mesenchymal Stem Cells in Stroke: A Phase I/IIa Study

Eighteen patients with stable, chronic stroke were enrolled in a two-year, open-label, single-arm study to evaluate the safety and clinical outcomes of surgical transplantation of modified bone marrow–derived mesenchymal stem cells. [Stroke] Abstract | Press Release

Chondrogenesis by Bone Marrow-Derived Mesenchymal Stem Cells Grown in Chondrocyte-Conditioned Medium for Auricular Reconstruction

Investigators determined if conditioned medium collected from cultured auricular chondrocytes could promote chondrogenic differentiation of bone marrow-derived mesenchymal stem cells. [J Tissue Eng Regen Med] Abstract

Mesenchymal Stromal/Stem Cells Do Not Ameliorate Experimental Autoimmune Encephalomyelitis and Are Not Detectable in the Central Nervous System of Transplanted Mice

Scientists made use of the established experimental autoimmune encephalomyelitis mouse model to investigate migration and therapeutic efficacy of murine bone-marrow derived mesenchymal stromal/stem cells. [Stem Cells Dev] Abstract

Mesenchymal Stem Cells in Cardiac Regeneration: A Detailed Progress Report of the Last 6 Years (2010–2015)

The authors summarize the major sources of mesenchymal stem cells involved in myocardial regeneration, the significant mechanisms involved in the process with a focus on studies (human and animal) conducted in the last six years and the challenges that remain to be addressed. [Stem Cell Res Ther] Full Article

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

DCGI Gives Limited Approval to Market First Allogeneic Cell Therapy Product in India Stempeutics Puts India on The “World Map of Regenerative Medicine”

Stempeutics Research announced that the Drugs Controller General India (DCGI) has granted limited approval for manufacturing & marketing of stem cell based biological product Stempeucel^® for the treatment of Buerger’s disease. [Stempeutics Research] Press Release

Americord Announces Increasing Stem Cell Yields, Including Record Collection

Americord announced that it has reached several milestones, including record cord blood collection volumes and record yields of total nucleated cell counts. [Americord Registry] Press Release

NEW International Conference on Stem Cell Engineering 2016
October 23-26, 2016
Toronto, Canada

Visit our events page to see a complete list of events in the mesenchymal cell community.

NEW Postdoctoral Position – MSC Research (GENYO)

NEW PhD Studentship – Vascular Tissue Engineering (Trinity College Dublin)

Scientific Communications and Publishing Coordinator (STEMCELL Technologies Inc.)

Research Technologist – Mesenchymal Stem Cell Biology (STEMCELL Technologies Inc.)

Faculty Position – Stem Cell Biology and Regenerative Medicine (University of Illinois, College of Medicine)

Postdoctoral Research Fellow – Neurobiology (McLean Hospital/Harvard Medical School)

Postdoctoral Positions – Immunology, Cancer, and Stem Cells (The University of Connecticut)

Postdoctoral Positions – Regenerative Medicine (Gladstone Institutes)

Postdoctoral Position – Bone/Stem Cell Biology (University of California, Los Angeles)

Postdoctoral Fellow – Skeletal Biology (Perelman School of Medicine)

Postdoctoral Scholar – Neurobiology (Penn State College of Medicine)

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