Mesenchymal Cell News 8.25 June 28, 2016 | |
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TOP STORYScientists performed in vitro functional studies in human adipose-tissue derived mesenchymal stem cells to investigate the effect of microRNA (miR)-550a-5p, miR-188-3p, and miR-382-3p on osteogenesis, adipogenesis and cell proliferation. [J Bone Miner Res] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROAn in vitro study was conducted using human alveolar bone marrow stem cells. Their cell viability, cell adhesion, and extracellular matrix formation were increased by reduced graphene oxide (RGO) and pulsed electromagnetic fields (PEMFs). The combination of RGO and PEMFs enhanced osteogenic differentiation. [Adv Healthc Mater] Abstract Researchers showed that the expression of TNF related apoptosis-inducing ligand and Dickouf-3, the promising anticancer proteins, increased in murine adipose-derived mesenchymal stromal cells following activation with TNF-α, resulting in the induction of apoptosis in cancer cells. [Sci Rep] Full Article Scientists demonstrated that long non-coding RNA H19 and microRNA-675 (miR-675) derived from H19 were significantly downregulated in bone marrow mesenchymal stem cells that were differentiating into adipocytes. Overexpression of H19 and miR-675 inhibited adipogenesis, while knockdown of their endogenous expression accelerated adipogenic differentiation. [Sci Rep] Full Article NR2F2 Regulates Chondrogenesis of Human Mesenchymal Stem Cells in Bioprinted Cartilage Investigators reported NR2F2 plays a crucial role in mesenchymal stem cell (MSC) chondrogenesis in bioprinted cartilage. NR2F2 over-expressed MSCs showed significantly enhanced chondrogenesis and NR2F2 knockdown cells demonstrated the exactly opposite behavior. [Biotechnol Bioeng] Abstract The effect of Gremlin2 on the bone morphogenetic protein (BMP)-2-induced osteogenesis of human bone marrow-derived mesenchymal stem cells remains ambiguous. Investigators analyzed the procedure in vitro and in vivo. [J Cell Biochem] Abstract Scientists used a next-generation sequencer to investigate the changes in gene expression during the osteoblastic differentiation of human multipotent mesenchymal stromal cells (hMSCs). The hMSCs used in this study possessed both multipotency and self-renewal ability. [J Cell Biochem] Abstract | Full Article Researchers analyzed the role of miR-27a in bone metabolism. Microarray analysis indicated that miR-27a expression was significantly reduced in osteoporotic patients. Analysis on mesenchymal stem cells derived from patients with osteoporosis indicated that osteoblastogenesis was reduced, whereas adipogenesis was increased. [Cell Physiol Biochem] Full Article Effects of Human Fibroblast-Derived Extracellular Matrix on Mesenchymal Stem Cells The authors investigated the effect of a bioengineered human dermal fibroblast-derived extracellular matrix on the regulation of human mesenchymal stem cell proliferation and multilineage differentiation. [Stem Cells Rev] Abstract IN VIVOResearchers used a rat disc stab injury model with administration of mesenchymal stromal cells at 3, 14, or 30 days post injury to evaluate the impact of interventional timing on intervertebral disc biochemistry and biomechanics. [J Orthop Res] Abstract Behavioral assessments and DBA tracing were used to evaluate the effects of combination of chondroitinase administration and brain-derived neurotrophic factor (BDNF)-mesenchymal stem cell (MSC) transplantation on axonal regeneration and functional improvement in SCT rats. [Spinal Cord] Abstract | |
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REVIEWSLarge-Scale Mesenchymal Stem/Stromal Cell Expansion: A Visualization Tool for Bioprocess Comparison The authors systematically reviewed the available mesenchymal stromal cell expansion literature and developed an interactive visualization tool for comparing the expansion processes. [Tissue Eng Part B Rev] Abstract The author reviews the concept of intra-articular injections of MSCs as a treatment for hemophilic arthropathy, using the literature on osteoarthritis as an example. [Expert Rev Hematol] Abstract Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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SCIENCE NEWSSanBio Presents Interim Results of Chronic Stroke Phase I/IIa Clinical Trial SanBio, Inc. presented the 12-month interim results of a Phase I/IIa clinical trial for the treatment of chronic motor deficits secondary to stroke. [Press release from SanBio, Inc. (Business Wire) discussing research presented at International Society of Stem Cell Research (ISSCR) Meeting, San Francisco] Press Release | |
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INDUSTRY NEWSThe Re-Programmer: Qian Receives Global Award for Stem Cell Research The 36-year-old assistant professor at University of Northern Carolina School of Medicine’s Department of Pathology and Laboratory Medicine has been recognized internationally for her scientific developments in cellular reprogramming and stem cell research. Qian is the first-ever recipient of the Boyalife, Science and Science Translational Medicine Award in Stem Cell and Regenerative Medicine. [University of Northern Carolina] Press Release Cytori Cell Therapy Receives Limited Approval for Osteoarthritis in Japan Cytori Therapeutics, Inc. announced that the use of Cytori Cell Therapy™ was approved for clinical use on June 24th, 2016 to treat knee osteoarthritis at the Tokyo Osteoarthritis Clinic under the Japanese ‘Act on the Safety of Regenerative Medicine’ that was enacted on November 25, 2014. [Cytori Therapeutics, Inc.] Press Release
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EVENTSNEW Stem Cell Society Singapore (SCSS) Symposium 2016 NEW World Stem Cell Summit 2016 Visit our events page to see a complete list of events in the mesenchymal cell community.
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JOB OPPORTUNITIESNEW PhD Position – Mesenchymal Stem Cells (University of Birmingham) NEW Postdoctoral Position – Bone and Stem Cell Research (University of Connecticut Health) Professor – Cardiovascular Research (Monash University) Postdoctoral Position – MSC Research (GENYO) PhD Studentship – Vascular Tissue Engineering (Trinity College Dublin) Postdoctoral Positions – Regenerative Medicine (Gladstone Institutes) Postdoctoral Position – Bone/Stem Cell Biology (University of California, Los Angeles) Postdoctoral Fellow – Skeletal Biology (Perelman School of Medicine) Postdoctoral Scholar – Neurobiology (Penn State College of Medicine) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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