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Pulmonary Cell News| Mesenchymal Cell News 8.26 July 5, 2016 | |
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TOP STORYDynamic Surfaces for the Study of Mesenchymal Stem Cell Growth through Adhesion Regulation Investigators used emerging rules of managing adhesion/cytoskeletal balance to prolong mesenchymal stem cells cultures by fabricating controllable nanoscale cell interfaces using immobilized peptides that may be enzymatically activated to change their function. [ACS Nano] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROEmploying a lung metastasis model of murine breast cancer, investigators found that tumor necrosis factor α (TNFα)-activated mesenchymal stromal cells (MSCs) strikingly enhanced tumor metastasis compared with normal MSCs. [Oncogene] Full Article Investigators found that incorporation of N-glycolylneuraminic acid onto mesenchymal stem cells (MSCs) during in vitro culture was a factor in the activation of complement by MSCs. [Mol Ther] Abstract Inactivated Mesenchymal Stem Cells Maintain Immunomodulatory Capacity Researchers generated mesenchymal stem cells that were unable to respond to inflammatory signals or secrete immunomodulatory factors but preserved their cellular integrity. [Stem Cells Dev] Abstract Scientists quantitatively assessed the ability of bone marrow-derived mesenchymal stem cells to differentiate toward bone, fat, cartilage, and tendon lineages when grown on commercially available scaffolds compared with control and native tendon tissue. [Arthroscopy] Abstract Researchers examined the effect of 9-10 months of cryostorage on the morphology, immunophenotype, colony-forming unit and differentiation capacity of fresh and cryopreserved human adipose-derived stromal/stem cells from the same donors. [Cells Tissues Organs] Full Article IN VIVOScientists showed that mesenchymal stem cell transplantation reduced the activities of NF-κB signaling and decreased microRNA-548e levels in the joint tissue in collagen-induced arthritis-mice, seemingly through activation of transforming growth factor β receptor signaling. [Sci Rep] Full Article The efficacy and safety of autologous bone marrow-derived mesenchymal stem cell transplantation in the treatment of alcoholic cirrhosis were investigated. [Hepatology] Abstract The authors investigated whether systemic infusion of allogeneic mesenchymal stem cells without genetic manipulation could prevent glucocorticoid-induced murine osteoporosis, whether anabolic and anticatabolic effects existed, and whether homing or immunomodulation underlay the putative therapeutic effects. [Stem Cells Transl Med] Abstract Scientists evaluated whether combination of chondroitinase administration and brain-derived neurotrophic factor (BDNF)-mesenchymal stem cell transplantation could provide an optimal effect for the treatment of spinal cord injury subjected to complete transection. [Spinal Cord] Abstract | |
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REVIEWSStem Cell-Based Therapies in Inflammatory Bowel Disease: Promises and Pitfalls In perianal Crohn’s disease, the objective is to deposit mesenchymal stem (stromal) cells locally in fistulizing tracts to down-regulate the local immune response and induce wound healing. Results from upcoming and ongoing clinical trials will set the path of these novel therapeutic options that have the capability to successfully treat severe refractory Crohn’s patients. [Therap Adv Gastroenterol] Full Article Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSBioRestorative Therapies, Inc. announced the completion of a human study entitled “Re-consenting and Follow-Up of Adults from a Retrospective Study Using Autologous Transplantation of Marrow Derived Mesenchymal Stem Cells to Degenerated Intervertebral Disc.” [BioRestorative Therapies, Inc.] Press Release Takeda Pharmaceutical Company Limited and TiGenix NV announced that the companies have entered into an exclusive ex-U.S. license, development and commercialization agreement for Cx601, a suspension of allogeneic adipose-derived stem cells injected intra-lesionally for the treatment of complex perianal fistulas in patients with Crohn’s disease. [Takeda Pharmaceutical Company Limited] Press Release | |
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EVENTSNEW TERMIS Americas Visit our events page to see a complete list of events in the mesenchymal cell community.
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JOB OPPORTUNITIESNEW Cell Biologist – Mesenchymal Stem Cells (Biostage) NEW Postdoctoral Fellow – Mesenchymal Stem Cells (University of Bergen) PhD Position – Mesenchymal Stem Cells (University of Birmingham) Postdoctoral Position – Bone and Stem Cell Research (University of Connecticut Health) Professor – Cardiovascular Research (Monash University) PhD Studentship – Vascular Tissue Engineering (Trinity College Dublin) Postdoctoral Position – Bone/Stem Cell Biology (University of California, Los Angeles) Postdoctoral Fellow – Skeletal Biology (Perelman School of Medicine) Postdoctoral Scholar – Neurobiology (Penn State College of Medicine) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Mesenchymal Cell News Volume 8.26 | Jul 5 2016
