Mesenchymal Cell News Volume 8.32 | Aug 16 2016

TOP STORY

Allogeneic Mesenchymal Stem Cells Stimulate Cartilage Regeneration and Are Safe for Single-Stage Cartilage Repair in Humans upon Mixture with Recycled Autologous Chondrons

Researchers hypothesized that mesenchymal stem cells have trophic effects that stimulate recycled chondrons (chondrocytes with their native pericellular matrix) to regenerate cartilage. [Stem Cells] Abstract

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IN VITRO

Enhanced Immunosuppression of T Cells by Sustained Presentation of Bioactive Interferon-γ within Three-Dimensional Mesenchymal Stem Cell Constructs

Researchers investigated whether microparticle-mediated presentation of bioactive interferon-γ within three-dimensional spheroidal mesenchymal stem/stromal cell aggregates could precisely regulate and induce sustained immunomodulatory activity. [Stem Cells Transl Med] Abstract | Full Article | Press Release

Ascorbate-Dependent Impact on Cell-Derived Matrix in Modulation of Stiffness and Rejuvenation of Infrapatellar Fat Derived Stem Cells toward Chondrogenesis

Scientists hypothesized that optimization of ascorbate treatment would maximize the rejuvenation effect of decellularized extracellular matrix on expanded stem cells from human infrapatellar fat pad in both proliferation and chondrogenic differentiation. [Biomed Mater] Abstract

Transplantation of Human Skin-Derived Mesenchymal Stromal Cells Improves Locomotor Recovery after Spinal Cord Injury in Rats

Investigators evaluated the human skin as an alternative source of adult mesenchymal stem cells suitable for autologous cell transplantation strategies for spinal cord injury. [Cell Mol Neurobiol] Abstract

IN VIVO

Carbon Monoxide Improves Efficacy of Mesenchymal Stromal Cells during Sepsis by Production of Specialized Proresolving Lipid Mediators

Scientists hypothesized that preconditioning of mesenchymal stromal cells with carbon monoxide ex vivo would promote further therapeutic benefit when cells are administered in vivo after the onset of polymicrobial sepsis in mice. [Crit Care Med] Abstract

Mesenchymal Stem Cells Enhance Nerve Regeneration in a Rat Sciatic Nerve Repair and Hindlimb Transplant Model

Researchers investigated the efficacy of local and intravenous mesenchymal stem cell administration to augment neuroregeneration in both a sciatic nerve cut-and-repair and rat hindlimb transplant model. [Sci Rep] Full Article

Long Noncoding RNA Related to Periodontitis Interacts with miR-182 to Upregulate Osteogenic Differentiation in Periodontal Mesenchymal Stem Cells of Periodontitis Patients

Scientists performed comprehensive long noncoding RNAs (lncRNAs) profiling by lncRNA microarray analysis and identified a novel lncRNA, osteogenesis impairment-related lncRNA of periodontal mesenchymal stem cells (PDLSCs) from periodontitis patients, the expression of which was significantly decreased in PDLSCs from periodontitis patients and was upregulated by osteogenic induction. [Cell Death Dis] Full Article

KDM5A Controls Bone Morphogenic Protein 2-Induced Osteogenic Differentiation of Bone Mesenchymal Stem Cells during Osteoporosis

By interrogating the microarray data from osteoporosis patients, researchers revealed an upregulation of the epigenetic modifying protein lysine-specific demethylase 5A (KDM5A) and decreased Runt-related transcription factor 2 expression. [Cell Death Dis] Full Article

Therapeutic Potential of Mesenchymal Stem Cell Based Therapy for Osteoarthritis

The authors compiled recent advancement in cellular based therapy more specifically in relation to mesenchymal stem cells in the treatment of osteoarthritis. [Clin Transl Med] Full Article

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Tissue Regeneration Therapeutics Engineered Mesenchymal Stromal Cells Advance Monoclonal Antibody Therapy

Tissue Regeneration Therapeutics Inc. (TRT) announced that a team of Canadian researchers has for the first time shown that TRT’s engineered mesenchymal stromal cell product can be used to deliver therapeutically useful monoclonal antibodies more effectively than administration of the mAbs themselves. [Tissue Regeneration Therapeutics Inc. (PR Newswire Association LLC)] Press Release

RetroSense Therapeutics Completes Low Dose Cohort in Clinical Trial of Novel Gene Therapy Application of Optogenetics

RetroSense Therapeutics LLC announced that the low dose cohort of patients has been safely dosed in the initial clinical trial to evaluate the safety of RST-001. No inflammation or ocular adverse events were seen in any of these patients, and biological activity has been confirmed. [RetroSense Therapeutics LLC (Business Wire)] Press Release

NIH Sets New Postdoc Stipend Levels

In response to a new rule governing overtime pay in the United States, the National Institutes of Health announced its new, increased postdoc stipend levels, which will go into effect December 1st 2016. [Science Careers] Editorial | Notice

From Bark to Bedside

Clinical trials in dogs and cats are booming. Over the past decade, researchers have conducted hundreds of studies on pets to discover new therapies and medicines. But despite some moderate successes, the field has yet to have a dramatic impact on human medicine—and some critics wonder whether it ever will. [Science] Editorial

US Grants for Zebrafish Studies on the Rise

A team at the NIH Office of Portfolio Analysis assessed trends in the agency’s funding of model-organism research between 2008 and 2015, through its R01 awards, the largest NIH grant program for individual investigators. Using a text-mining algorithm and manual searches, they studied grant data for four animal models. The analysis revealed that grants for zebrafish studies accounted for 0.8% of all R01 awards in 2008, but for 1.27% in 2015 — a rise of almost 60%. [Nature News] Editorial

UK Government Gives Brexit Science Funding Guarantee

British scientists say they’re relieved by a government promise to guarantee them funding for existing EU research projects, even after the country leaves the European Union. But the reassurance only partly allays concerns about Brexit’s effect on UK science. [Nature News] Editorial

NEW Bone & Cartilage: From Development to Human Diseases
October 24-28, 2016
Suzhou, China

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NEW Postdoctoral Fellow – Immunomodulatory Properties of Mesenchymal Stem Cells (NYU Langone Medical Center)

Postdoctoral Fellow – Stem Cell Functions in the Hematopoietic System and Other Systems Derived from the Mesoderm (University of Illinois at Chicago)

Assistant or Associate Member – Stem Cell/Gene Therapy (Fred Hutchinson Cancer Research Center)

PhD Position – Ultrasound Stimulation of Mesenchymal Stem Cells for Tissue Repair and Regeneration (University of Birmingham)

Postdoctoral Position – Organogenesis and Mesenchymal Stem Cells (University of Southern California)

Postdoctoral Positions – GLUT4 Trafficking in Adipose and Muscle Cells (ShanghaiTech University)

Postdoctoral Position – Tumor Microenvironment in Sarcoma Progression (Universita’ di Bologna)

Postdoctoral Research Fellow – Stem Cell Pathways in Mesenchymal Tumors (University of Miami Health System)

Cell Biologist – Mesenchymal Stem Cells (Biostage)

Postdoctoral Position – Bone and Stem Cell Research (University of Connecticut Health)

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